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- Stannin abstract "Stannins are small proteins that consist of a single transmembrane helix, an unstructured linker domain, and a cytoplasmic domain. The transmembrane region contains a conserved cysteine residue (Cys32) that, together with Cys34 found in the stannin unstructured linker domain, constitutes the putative trimethyltin-binding site, close to the lipid/solvent interface.The unstructured protein region connects two adjacent helical domains. It contains a conserved CXC metal-binding motif and a putative 14-3-3-zeta binding domain. Upon coordinating dimethytin, considerable structural or dynamic changes in the flexible loop region of SNN may take place, recruiting other binding partners such as 14-3-3-zeta, and thereby initiating the apoptotic cascade.The cytoplasmic domain forms a distorted helix that is partially absorbed into the plane of the lipid bilayer. It interacts with the surface of the lipid bilayer, and contributes to the initiation of the apoptotic cascade on binding of the unstructured linker domain to dimethyltin.".
- Stannin symbol "SNN_transmemb".
- Stannin thumbnail 1zza.png?width=300.
- Stannin wikiPageID "14712213".
- Stannin wikiPageLength "1922".
- Stannin wikiPageOutDegree "5".
- Stannin wikiPageRevisionID "617819846".
- Stannin wikiPageWikiLink Apoptosis.
- Stannin wikiPageWikiLink Category:Protein_domains.
- Stannin wikiPageWikiLink Category:Single-pass_transmembrane_proteins.
- Stannin wikiPageWikiLink SNN_(gene).
- Stannin wikiPageWikiLink Trimethyltin.
- Stannin wikiPageWikiLinkText "stannin".
- Stannin caption "Stannin".
- Stannin interpro "IPR015135".
- Stannin opmFamily "180".
- Stannin opmProtein "1".
- Stannin pdb "A:1-33".
- Stannin pfam "PF09049".
- Stannin symbol "SNN_transmemb".
- Stannin width "200".
- Stannin wikiPageUsesTemplate Template:InterPro_content.
- Stannin wikiPageUsesTemplate Template:Membrane-protein-stub.
- Stannin wikiPageUsesTemplate Template:PDB3.
- Stannin wikiPageUsesTemplate Template:Pfam_box.
- Stannin wikiPageUsesTemplate Template:Reflist.
- Stannin subject Category:Protein_domains.
- Stannin subject Category:Single-pass_transmembrane_proteins.
- Stannin hypernym Proteins.
- Stannin type Biomolecule.
- Stannin type Protein.
- Stannin type Chemical.
- Stannin type Domain.
- Stannin type Thing.
- Stannin type Q206229.
- Stannin type Q8054.
- Stannin comment "Stannins are small proteins that consist of a single transmembrane helix, an unstructured linker domain, and a cytoplasmic domain. The transmembrane region contains a conserved cysteine residue (Cys32) that, together with Cys34 found in the stannin unstructured linker domain, constitutes the putative trimethyltin-binding site, close to the lipid/solvent interface.The unstructured protein region connects two adjacent helical domains.".
- Stannin label "Stannin".
- Stannin sameAs Q7600127.
- Stannin sameAs m.03gt_gm.
- Stannin sameAs Q7600127.
- Stannin wasDerivedFrom Stannin?oldid=617819846.
- Stannin depiction 1zza.png.
- Stannin isPrimaryTopicOf Stannin.