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- Spherocytosis abstract "Spherocytosis is an auto-hemolytic anemia (a disease of the blood) characterized by the production of spherocytes - red blood cells (RBCs), or erythrocytes, that are sphere-shaped, rather than bi-concave disk shaped. Spherocytes are found in hereditary spherocytosis and autoimmune hemolytic anemia.It almost always refers to hereditary spherocytosis. This is caused by a molecular defect in one or more of the proteins of the red blood cell cytoskeleton, including, spectrin, ankyrin, Band 3, or Protein 4.2. Because the cell skeleton has a defect, the blood cell contracts to its most surface-tension efficient and least flexible configuration, a sphere. Though the spherocytes have a smaller surface area through which oxygen and carbon dioxide can be exchanged, they in themselves perform adequately to maintain healthy oxygen supplies. However, they have a high osmotic fragility--when placed into water, they are more likely to burst than normal red blood cells. These cells are more prone to physical degradation.A1C tests are also compromised by the disorder and must not be used to measure time-based blood glucose levels. Instead, diabetes related glucose tests are limited to fructosamine, which measures the amount of glucose in the blood over the past three weeks on average. This is a marked contrast to A1C tests that measure blood glucose over an average span of three months.They are most commonly found in immunologically-mediated hemolytic anemias and in hereditary spherocytosis, but the former would have a positive direct Coombs test and the latter would not. The misshapen but otherwise healthy red blood cells are mistaken by the spleen for old or damaged red blood cells and it thus constantly breaks them down, causing a cycle whereby the body destroys its own blood supply (auto-hemolysis).The term \"non hereditary spherocytosis\" is occasionally used, albeit rarely.".
- Spherocytosis thumbnail Hereditary_Spherocytosis_smear_2010-03-17.JPG?width=300.
- Spherocytosis wikiPageExternalLink 206107-overview.
- Spherocytosis wikiPageExternalLink nord81.asp.
- Spherocytosis wikiPageExternalLink 1220.htm.
- Spherocytosis wikiPageID "226540".
- Spherocytosis wikiPageLength "3585".
- Spherocytosis wikiPageOutDegree "28".
- Spherocytosis wikiPageRevisionID "679086708".
- Spherocytosis wikiPageWikiLink Anemia.
- Spherocytosis wikiPageWikiLink Ankyrin.
- Spherocytosis wikiPageWikiLink Autoimmune_hemolytic_anemia.
- Spherocytosis wikiPageWikiLink Blood.
- Spherocytosis wikiPageWikiLink Carbon_dioxide.
- Spherocytosis wikiPageWikiLink Category:Abnormal_clinical_and_laboratory_findings_for_RBCs.
- Spherocytosis wikiPageWikiLink Category:Anemias.
- Spherocytosis wikiPageWikiLink Category:Red_blood_cell_disorders.
- Spherocytosis wikiPageWikiLink Coombs_test.
- Spherocytosis wikiPageWikiLink Cytoskeleton.
- Spherocytosis wikiPageWikiLink Genetic_disorder.
- Spherocytosis wikiPageWikiLink Hemolysis.
- Spherocytosis wikiPageWikiLink Hemolytic_anemia.
- Spherocytosis wikiPageWikiLink Hereditary_spherocytosis.
- Spherocytosis wikiPageWikiLink List_of_hematologic_conditions.
- Spherocytosis wikiPageWikiLink Osmosis.
- Spherocytosis wikiPageWikiLink Oxygen.
- Spherocytosis wikiPageWikiLink Protein.
- Spherocytosis wikiPageWikiLink Red_blood_cell.
- Spherocytosis wikiPageWikiLink Spectrin.
- Spherocytosis wikiPageWikiLink Spleen.
- Spherocytosis wikiPageWikiLink File:Hereditary_Spherocytosis_smear_2010-03-17.JPG.
- Spherocytosis wikiPageWikiLinkText "Spherocyte".
- Spherocytosis wikiPageWikiLinkText "Spherocytosis".
- Spherocytosis wikiPageWikiLinkText "hemolytic spherocytosis".
- Spherocytosis wikiPageWikiLinkText "non-hereditary spherocytosis".
- Spherocytosis wikiPageWikiLinkText "spherocytosis".
- Spherocytosis wikiPageUsesTemplate Template:Abnormal_clinical_and_laboratory_findings.
- Spherocytosis wikiPageUsesTemplate Template:About.
- Spherocytosis wikiPageUsesTemplate Template:Reflist.
- Spherocytosis subject Category:Abnormal_clinical_and_laboratory_findings_for_RBCs.
- Spherocytosis subject Category:Anemias.
- Spherocytosis subject Category:Red_blood_cell_disorders.
- Spherocytosis hypernym Anemia.
- Spherocytosis type Disease.
- Spherocytosis type Disorder.
- Spherocytosis comment "Spherocytosis is an auto-hemolytic anemia (a disease of the blood) characterized by the production of spherocytes - red blood cells (RBCs), or erythrocytes, that are sphere-shaped, rather than bi-concave disk shaped. Spherocytes are found in hereditary spherocytosis and autoimmune hemolytic anemia.It almost always refers to hereditary spherocytosis.".
- Spherocytosis label "Spherocytosis".
- Spherocytosis sameAs Q11181178.
- Spherocytosis sameAs كثرة_الكريات_الحمر_الكروية.
- Spherocytosis sameAs اسفروسیتوز.
- Spherocytosis sameAs Sferocitosi.
- Spherocytosis sameAs 球状赤血球.
- Spherocytosis sameAs Sfærocytose.
- Spherocytosis sameAs m.01h0xn.
- Spherocytosis sameAs Sferositoz.
- Spherocytosis sameAs Q11181178.
- Spherocytosis wasDerivedFrom Spherocytosis?oldid=679086708.
- Spherocytosis depiction Hereditary_Spherocytosis_smear_2010-03-17.JPG.
- Spherocytosis isPrimaryTopicOf Spherocytosis.