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- Spectrin abstract "Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells. Spectrin forms pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. The hexagonal arrangements are formed by tetramers of spectrin subunits associating with short actin filaments at either end of the tetramer. These short actin filaments act as junctional complexes allowing the formation of the hexagonal mesh. The protein is named spectrin since it was first isolated as a major protein component of human red blood cells which had been treated with mild detergents; the detergents lysed the cells and the hemoglobin and other cytoplasmic components were washed out. In the light microscope the basic shape of the red blood cell could still be seen as the spectrin containing submembranous cytoskeleton preserved the shape of the cell in outline. This became known as a red blood cell \"ghost\" (spectre), and so the major protein of the ghost was named spectrin. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytoskeleton. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to the death of the cell. Spectrin subunits may also be cleaved by caspase family enzymes, and calpain and caspase produce different spectrin breakdown products which can be detected by western blotting with appropriate antibodies. Calpain cleavage may indicate activation of necrosis, while caspase cleavage may indicate apoptosis.".
- Spectrin thumbnail Cytoskeleton_(Elliptocytosis).png?width=300.
- Spectrin wikiPageID "2864344".
- Spectrin wikiPageLength "9501".
- Spectrin wikiPageOutDegree "53".
- Spectrin wikiPageRevisionID "682549111".
- Spectrin wikiPageWikiLink Actin.
- Spectrin wikiPageWikiLink Ankyrin.
- Spectrin wikiPageWikiLink Apoptosis.
- Spectrin wikiPageWikiLink Band_3.
- Spectrin wikiPageWikiLink Bleb_(cell_biology).
- Spectrin wikiPageWikiLink Caenorhabditis_elegans.
- Spectrin wikiPageWikiLink Calcium_signaling.
- Spectrin wikiPageWikiLink Calmodulin.
- Spectrin wikiPageWikiLink Calpain.
- Spectrin wikiPageWikiLink Caspase.
- Spectrin wikiPageWikiLink Category:Cytoskeleton.
- Spectrin wikiPageWikiLink Cell_membrane.
- Spectrin wikiPageWikiLink Cytoskeleton.
- Spectrin wikiPageWikiLink Diffuse_axonal_injury.
- Spectrin wikiPageWikiLink Drosophila.
- Spectrin wikiPageWikiLink EPB41.
- Spectrin wikiPageWikiLink Enzyme.
- Spectrin wikiPageWikiLink GATA1.
- Spectrin wikiPageWikiLink GYPA.
- Spectrin wikiPageWikiLink Glycophorin_C.
- Spectrin wikiPageWikiLink Hereditary_elliptocytosis.
- Spectrin wikiPageWikiLink Hereditary_spherocytosis.
- Spectrin wikiPageWikiLink Invertebrate.
- Spectrin wikiPageWikiLink Long_QT_syndrome.
- Spectrin wikiPageWikiLink Myocardial_cell.
- Spectrin wikiPageWikiLink Myofibril.
- Spectrin wikiPageWikiLink Necrosis.
- Spectrin wikiPageWikiLink Neuromuscular_junction.
- Spectrin wikiPageWikiLink Neuron.
- Spectrin wikiPageWikiLink Neurotransmission.
- Spectrin wikiPageWikiLink Phenotype.
- Spectrin wikiPageWikiLink Protein.
- Spectrin wikiPageWikiLink Proteolysis.
- Spectrin wikiPageWikiLink Red_blood_cell.
- Spectrin wikiPageWikiLink SPTAN1.
- Spectrin wikiPageWikiLink SPTB.
- Spectrin wikiPageWikiLink SPTBN1.
- Spectrin wikiPageWikiLink SPTBN2.
- Spectrin wikiPageWikiLink SPTBN4.
- Spectrin wikiPageWikiLink SPTBN5.
- Spectrin wikiPageWikiLink Scaffolding.
- Spectrin wikiPageWikiLink Spectrin,_alpha_1.
- Spectrin wikiPageWikiLink Spectrin_repeat.
- Spectrin wikiPageWikiLink Transcription_factor.
- Spectrin wikiPageWikiLink Western_blot.
- Spectrin wikiPageWikiLink Wild_type.
- Spectrin wikiPageWikiLink File:Cytoskeleton_(Elliptocytosis).png.
- Spectrin wikiPageWikiLink File:Spectrin_localization_under_the_neuronal_plasme_membrane..jpg.
- Spectrin wikiPageWikiLinkText "Spectrin".
- Spectrin wikiPageWikiLinkText "spectrin tetramers".
- Spectrin wikiPageWikiLinkText "spectrin".
- Spectrin wikiPageWikiLinkText "β-spectrin".
- Spectrin wikiPageUsesTemplate Template:Cytoskeletal_Proteins.
- Spectrin wikiPageUsesTemplate Template:Membrane_proteins.
- Spectrin wikiPageUsesTemplate Template:Proteopedia.
- Spectrin wikiPageUsesTemplate Template:Reflist.
- Spectrin subject Category:Cytoskeleton.
- Spectrin hypernym Protein.
- Spectrin type Protein.
- Spectrin comment "Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells. Spectrin forms pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. The hexagonal arrangements are formed by tetramers of spectrin subunits associating with short actin filaments at either end of the tetramer.".
- Spectrin label "Spectrin".
- Spectrin sameAs Q420870.
- Spectrin sameAs Espectrina.
- Spectrin sameAs Spektrin.
- Spectrin sameAs Espectrina.
- Spectrin sameAs Spettrina.
- Spectrin sameAs スペクトリン.
- Spectrin sameAs m.087nvd.
- Spectrin sameAs Спектрин.
- Spectrin sameAs Spektrin.
- Spectrin sameAs Q420870.
- Spectrin sameAs 血影蛋白.
- Spectrin wasDerivedFrom Spectrin?oldid=682549111.
- Spectrin depiction Cytoskeleton_(Elliptocytosis).png.
- Spectrin isPrimaryTopicOf Spectrin.