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- Smoothened_agonist abstract "Smoothened agonist (SAG) was one of the first small-molecule agonists developed for the protein Smoothened, a key part of the hedgehog signaling pathway, which is involved in brain development as well as having a number of other functions in the body. Smoothened agonist has been shown to aid proliferation and survival of developing neurons, and prevent drug-induced brain injury. When injected into the cerebellum of newborn mice with an induced Down's syndrome-like condition, Smoothened agonist was able to stimulate normal cerebellum development, resulting in significant behavioural improvement once the mice had grown to adulthood.".
- Smoothened_agonist casNumber "912545-86-9".
- Smoothened_agonist casSupplemental "364590-63-6 (hydrochloride)".
- Smoothened_agonist iupacName "3-chloro-N-[(1r,4r)-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]benzo[b]thiophene-2-carboxamide".
- Smoothened_agonist pubchem "5284330".
- Smoothened_agonist thumbnail Chemical_structural_formula_of_smoothened_agonist.png?width=300.
- Smoothened_agonist wikiPageID "40456795".
- Smoothened_agonist wikiPageLength "3745".
- Smoothened_agonist wikiPageOutDegree "7".
- Smoothened_agonist wikiPageRevisionID "686028646".
- Smoothened_agonist wikiPageWikiLink Category:Down_syndrome.
- Smoothened_agonist wikiPageWikiLink Category:Receptor_agonists.
- Smoothened_agonist wikiPageWikiLink Cerebellum.
- Smoothened_agonist wikiPageWikiLink Down_syndrome.
- Smoothened_agonist wikiPageWikiLink Hedgehog_signaling_pathway.
- Smoothened_agonist wikiPageWikiLink Neuron.
- Smoothened_agonist wikiPageWikiLink Smoothened.
- Smoothened_agonist wikiPageWikiLinkText "Smoothened agonist".
- Smoothened_agonist c "28".
- Smoothened_agonist casNumber "912545".
- Smoothened_agonist casSupplemental "364590".
- Smoothened_agonist chemspiderid "21541484".
- Smoothened_agonist cl "1".
- Smoothened_agonist h "28".
- Smoothened_agonist iupacName "3".
- Smoothened_agonist molecularWeight "490.06".
- Smoothened_agonist n "3".
- Smoothened_agonist o "1".
- Smoothened_agonist pubchem "5284330".
- Smoothened_agonist s "1".
- Smoothened_agonist smiles "ClC1=CSC5=CC=CC=C51".
- Smoothened_agonist stdinchi "1".
- Smoothened_agonist stdinchikey "VFSUUTYAEQOIMW-YHBQERECSA-N".
- Smoothened_agonist width "250".
- Smoothened_agonist wikiPageUsesTemplate Template:Cascite.
- Smoothened_agonist wikiPageUsesTemplate Template:Chemspidercite.
- Smoothened_agonist wikiPageUsesTemplate Template:Drugbankcite.
- Smoothened_agonist wikiPageUsesTemplate Template:Drugbox.
- Smoothened_agonist wikiPageUsesTemplate Template:Reflist.
- Smoothened_agonist subject Category:Down_syndrome.
- Smoothened_agonist subject Category:Receptor_agonists.
- Smoothened_agonist hypernym Agonists.
- Smoothened_agonist type ChemicalSubstance.
- Smoothened_agonist type Drug.
- Smoothened_agonist type ChemicalObject.
- Smoothened_agonist type Thing.
- Smoothened_agonist type Q8386.
- Smoothened_agonist comment "Smoothened agonist (SAG) was one of the first small-molecule agonists developed for the protein Smoothened, a key part of the hedgehog signaling pathway, which is involved in brain development as well as having a number of other functions in the body. Smoothened agonist has been shown to aid proliferation and survival of developing neurons, and prevent drug-induced brain injury.".
- Smoothened_agonist label "Smoothened agonist".
- Smoothened_agonist sameAs Q15410188.
- Smoothened_agonist sameAs m.0wzt69p.
- Smoothened_agonist sameAs Agonist_zaglađenog_receptora.
- Smoothened_agonist sameAs Agonist_zaglađenog_receptora.
- Smoothened_agonist sameAs Q15410188.
- Smoothened_agonist wasDerivedFrom Smoothened_agonist?oldid=686028646.
- Smoothened_agonist depiction Chemical_structural_formula_of_smoothened_agonist.png.
- Smoothened_agonist isPrimaryTopicOf Smoothened_agonist.