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- Shelphs abstract "Shewanella-like phosphatases, abbreviated as Shelphs, are a group of enzymes structurally related to protein serine/threonine phosphatases (PPP family). Unlike the canonical subfamilies found in eukaryotes (PP1, PP2A, calcineurin, PP5 and PPEF/PP7), Shelphs span the eukaryote-prokaryote boundary and are found in several genera of proteobacteria, in plants, red algae, fungi and some unicellular parasites, including a causative agent of malaria Plasmodium, Cryptosporidium and kinetoplastids (Trypanosoma and Leishmania species).The prototypic member of the group, a phosphatase from a psychrophilic bacterium Shewanella, has been studied as a model to understand the mechanisms that contribute to the high catalytic efficiency of enzymes from organisms adapted to low temperatures. Although PPP phosphatases in general are serine/threonine specific, Shewanella phosphatase is tyrosine specific. One of the two Shelph isoforms in plants is predicted to be located in the chloroplast.Due to the absence of Shelphs in humans, these phosphatases have recently attracted attention as potential targets for new antiparasitic drug discovery.".
- Shelphs wikiPageID "23223315".
- Shelphs wikiPageLength "4390".
- Shelphs wikiPageOutDegree "22".
- Shelphs wikiPageRevisionID "702873693".
- Shelphs wikiPageWikiLink Category:Enzymes.
- Shelphs wikiPageWikiLink Chloroplast.
- Shelphs wikiPageWikiLink Cryptosporidium.
- Shelphs wikiPageWikiLink Drug_discovery.
- Shelphs wikiPageWikiLink Enzyme.
- Shelphs wikiPageWikiLink Eukaryote.
- Shelphs wikiPageWikiLink Fungus.
- Shelphs wikiPageWikiLink Kinetoplastida.
- Shelphs wikiPageWikiLink Leishmania.
- Shelphs wikiPageWikiLink Malaria.
- Shelphs wikiPageWikiLink Phosphatase.
- Shelphs wikiPageWikiLink Plant.
- Shelphs wikiPageWikiLink Plasmodium.
- Shelphs wikiPageWikiLink Prokaryote.
- Shelphs wikiPageWikiLink Proteobacteria.
- Shelphs wikiPageWikiLink Psychrophile.
- Shelphs wikiPageWikiLink Red_algae.
- Shelphs wikiPageWikiLink Serine.
- Shelphs wikiPageWikiLink Shewanella.
- Shelphs wikiPageWikiLink Threonine.
- Shelphs wikiPageWikiLink Trypanosoma.
- Shelphs wikiPageWikiLink Tyrosine.
- Shelphs wikiPageUsesTemplate Template:Orphan.
- Shelphs wikiPageUsesTemplate Template:Reflist.
- Shelphs subject Category:Enzymes.
- Shelphs hypernym Group.
- Shelphs type Band.
- Shelphs comment "Shewanella-like phosphatases, abbreviated as Shelphs, are a group of enzymes structurally related to protein serine/threonine phosphatases (PPP family).".
- Shelphs label "Shelphs".
- Shelphs sameAs Q7493928.
- Shelphs sameAs m.065z5ry.
- Shelphs sameAs Q7493928.
- Shelphs wasDerivedFrom Shelphs?oldid=702873693.
- Shelphs isPrimaryTopicOf Shelphs.