Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Serpin> ?p ?o }
- Serpin abstract "Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. The acronym serpin was originally coined because the first serpins to be identified act on chymotrypsin-like serine proteases (serine protease inhibitors). They are notable for their unusual mechanism of action, in which they irreversibly inhibit their target protease by undergoing a large conformational change to disrupt its active site. This contrasts with the more common competitive mechanism for protease inhibitors that bind to and block access to the protease active site.Protease inhibition by serpins controls an array of biological processes, including coagulation and inflammation, and consequently these proteins are the target of medical research. Their unique conformational change also makes them of interest to the structural biology and protein folding research communities. The conformational-change mechanism confers certain advantages, but it also has drawbacks: serpins are vulnerable to mutations that can result in serpinopathies such as protein misfolding and the formation of inactive long-chain polymers. Serpin polymerisation not only reduces the amount of active inhibitor, but also leads to accumulation of the polymers, causing cell death and organ failure.While most serpins control proteolytic cascades, some proteins with a serpin structure are not enzyme inhibitors, but instead perform diverse functions such as storage (as in egg white—ovalbumin), transport as in hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and molecular chaperoning (HSP47). The term serpin is used to describe these members as well, despite their non-inhibitory function, since they are evolutionarily related.".
- Serpin symbol "Serpin".
- Serpin thumbnail Serpin_(stressed).png?width=300.
- Serpin wikiPageExternalLink gettins_peter.html.
- Serpin wikiPageExternalLink huntingtonlab.cimr.cam.ac.uk.
- Serpin wikiPageExternalLink famsum?family=I4.
- Serpin wikiPageExternalLink index.htm.
- Serpin wikiPageExternalLink tom.roberts.php.
- Serpin wikiPageExternalLink viewer.fcgi?db=nuccore&id=47125085.
- Serpin wikiPageExternalLink fluhr.
- Serpin wikiPageExternalLink whisstock-lab.med.monash.edu.au.
- Serpin wikiPageExternalLink frank-church-1.
- Serpin wikiPageID "564590".
- Serpin wikiPageLength "129233".
- Serpin wikiPageOutDegree "365".
- Serpin wikiPageRevisionID "707947404".
- Serpin wikiPageWikiLink Active_site.
- Serpin wikiPageWikiLink Allosteric_regulation.
- Serpin wikiPageWikiLink Alpha-1_antitrypsin.
- Serpin wikiPageWikiLink Alpha_1-antichymotrypsin.
- Serpin wikiPageWikiLink Alpha_1-antitrypsin_deficiency.
- Serpin wikiPageWikiLink Alpha_2-antiplasmin.
- Serpin wikiPageWikiLink Alpha_helix.
- Serpin wikiPageWikiLink Alzheimers_disease.
- Serpin wikiPageWikiLink Angioedema.
- Serpin wikiPageWikiLink Angiotensin.
- Serpin wikiPageWikiLink Animal.
- Serpin wikiPageWikiLink Anticoagulant.
- Serpin wikiPageWikiLink Antithrombin.
- Serpin wikiPageWikiLink Antithrombin_III_deficiency.
- Serpin wikiPageWikiLink Antitrypsin-related_protein.
- Serpin wikiPageWikiLink Apoptosis.
- Serpin wikiPageWikiLink Arabidopsis_thaliana.
- Serpin wikiPageWikiLink Archaea.
- Serpin wikiPageWikiLink Asthma.
- Serpin wikiPageWikiLink Bacteria.
- Serpin wikiPageWikiLink Beta_sheet.
- Serpin wikiPageWikiLink Biochemistry.
- Serpin wikiPageWikiLink Bird.
- Serpin wikiPageWikiLink Bleeding.
- Serpin wikiPageWikiLink C-terminus.
- Serpin wikiPageWikiLink C1-inhibitor.
- Serpin wikiPageWikiLink Caenorhabditis_elegans.
- Serpin wikiPageWikiLink Calpain.
- Serpin wikiPageWikiLink Carrier_protein.
- Serpin wikiPageWikiLink Caspase.
- Serpin wikiPageWikiLink Catalytic_triad.
- Serpin wikiPageWikiLink Category:Serine_protease_inhibitors.
- Serpin wikiPageWikiLink Cathepsin_G.
- Serpin wikiPageWikiLink Cell_death.
- Serpin wikiPageWikiLink Cell_signaling.
- Serpin wikiPageWikiLink Cellulosome.
- Serpin wikiPageWikiLink Centroacinar_cell.
- Serpin wikiPageWikiLink Chaperone_(protein).
- Serpin wikiPageWikiLink Chromatin_remodeling.
- Serpin wikiPageWikiLink Chromosome.
- Serpin wikiPageWikiLink Chronic_obstructive_pulmonary_disease.
- Serpin wikiPageWikiLink Chymase.
- Serpin wikiPageWikiLink Chymotrypsin.
- Serpin wikiPageWikiLink Cirrhosis.
- Serpin wikiPageWikiLink Clostridium_thermocellum.
- Serpin wikiPageWikiLink Coagulation.
- Serpin wikiPageWikiLink Cofactor_(biochemistry).
- Serpin wikiPageWikiLink Collagen.
- Serpin wikiPageWikiLink Competitive_inhibition.
- Serpin wikiPageWikiLink Conceptus.
- Serpin wikiPageWikiLink Conformational_change.
- Serpin wikiPageWikiLink Cortisol.
- Serpin wikiPageWikiLink Cowpox.
- Serpin wikiPageWikiLink Cysteine.
- Serpin wikiPageWikiLink Cysteine_protease.
- Serpin wikiPageWikiLink Cytotoxicity.
- Serpin wikiPageWikiLink Dementia.
- Serpin wikiPageWikiLink Developmental_biology.
- Serpin wikiPageWikiLink Dockerin.
- Serpin wikiPageWikiLink Drosophila.
- Serpin wikiPageWikiLink Drosophila_melanogaster.
- Serpin wikiPageWikiLink Dynamic_equilibrium.
- Serpin wikiPageWikiLink Egg_white.
- Serpin wikiPageWikiLink Endocytosis.
- Serpin wikiPageWikiLink Endometrium.
- Serpin wikiPageWikiLink Endoplasmic_reticulum.
- Serpin wikiPageWikiLink Enzyme_catalysis.
- Serpin wikiPageWikiLink Enzyme_inhibitor.
- Serpin wikiPageWikiLink Enzyme_kinetics.
- Serpin wikiPageWikiLink Ester.
- Serpin wikiPageWikiLink Estrogen.
- Serpin wikiPageWikiLink Eukaryote.
- Serpin wikiPageWikiLink Exosite.
- Serpin wikiPageWikiLink Extremophile.
- Serpin wikiPageWikiLink Factor_IX.
- Serpin wikiPageWikiLink Factor_X.
- Serpin wikiPageWikiLink Factor_XI.
- Serpin wikiPageWikiLink Familial_encephalopathy_with_neuroserpin_inclusion_bodies.
- Serpin wikiPageWikiLink Fibrinolysis.
- Serpin wikiPageWikiLink Folding_(chemistry).
- Serpin wikiPageWikiLink Fondaparinux.
- Serpin wikiPageWikiLink Fungus.
- Serpin wikiPageWikiLink Gene_knockout.
- Serpin wikiPageWikiLink Genetic_disorder.