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- Samidorphan abstract "Samidorphan (INN, USAN) (developmental code names ALKS-33, RDC-0313), also known as 3-carboxamido-4-hydroxynaltrexone, is an opioid antagonist that selectively blocks the μ-opioid receptor, without blocking the δ-opioid or κ-opioid receptors. It has been investigated for the treatment of alcoholism and cocaine addiction by its developer, Alkermes, showing similar efficacy to naltrexone but possibly with reduced side effects.However, it has attracted much more attention as part of the combination product ALKS-5461, where samidorphan is combined with the mixed μ-opioid agonist and κ-opioid antagonist opioid modulator buprenorphine, as an antidepressant. Buprenorphine has shown antidepressant effects in some human studies, thought to be because of its antagonist effects at the κ-opioid receptor, but has not been further developed for this application because of its μ-opioid agonist effects and consequent abuse potential. By combining buprenorphine with samidorphan to block the μ-opioid agonist effects, the combination acts more like a selective κ-opioid antagonist, and produces only antidepressant effects, without typical μ-opioid effects being evident.Samidorphan is also being studied in combination with olanzapine, as ALKS-3831, for use in schizophenia. It is hoped it will be effective while resulting in less weight gain. Phase II studies have begun.".
- Samidorphan casNumber "852626-89-2".
- Samidorphan fdaUniiCode "7W2581Z5L8".
- Samidorphan iupacName "17-(Cyclopropylmethyl)-4,14-dihydroxy-6-oxomorphinan-3-carboxamide".
- Samidorphan pubchem "11667832".
- Samidorphan thumbnail Samidorphan_structure.svg?width=300.
- Samidorphan wikiPageID "36269232".
- Samidorphan wikiPageLength "5137".
- Samidorphan wikiPageOutDegree "25".
- Samidorphan wikiPageRevisionID "696945545".
- Samidorphan wikiPageWikiLink 8-Carboxamidocyclazocine.
- Samidorphan wikiPageWikiLink ALKS-3831.
- Samidorphan wikiPageWikiLink Alcoholism.
- Samidorphan wikiPageWikiLink Alkermes_(company).
- Samidorphan wikiPageWikiLink Antidepressant.
- Samidorphan wikiPageWikiLink Buprenorphine.
- Samidorphan wikiPageWikiLink samidorphan.
- Samidorphan wikiPageWikiLink Category:Cyclopropanes.
- Samidorphan wikiPageWikiLink Category:Ketones.
- Samidorphan wikiPageWikiLink Category:Morphinans.
- Samidorphan wikiPageWikiLink Category:Opioid_antagonists.
- Samidorphan wikiPageWikiLink Category:Synthetic_opioids.
- Samidorphan wikiPageWikiLink Cocaine_dependence.
- Samidorphan wikiPageWikiLink Cyprodime.
- Samidorphan wikiPageWikiLink International_nonproprietary_name.
- Samidorphan wikiPageWikiLink JDTic.
- Samidorphan wikiPageWikiLink Naltrexone.
- Samidorphan wikiPageWikiLink Olanzapine.
- Samidorphan wikiPageWikiLink Opioid_antagonist.
- Samidorphan wikiPageWikiLink Opioid_modulator.
- Samidorphan wikiPageWikiLink Side_effect.
- Samidorphan wikiPageWikiLink United_States_Adopted_Name.
- Samidorphan wikiPageWikiLink Δ-opioid_receptor.
- Samidorphan wikiPageWikiLink Κ-opioid_receptor.
- Samidorphan wikiPageWikiLink Μ-opioid_receptor.
- Samidorphan wikiPageWikiLinkText "Samidorphan".
- Samidorphan wikiPageWikiLinkText "samidorphan".
- Samidorphan c "21".
- Samidorphan casNumber "852626".
- Samidorphan chemspiderid "23259667".
- Samidorphan eliminationHalfLife "-32400.0".
- Samidorphan h "26".
- Samidorphan inchi "1".
- Samidorphan inchikey "RYIDHLJADOKWFM-MAODMQOUBS".
- Samidorphan iupacName "17".
- Samidorphan kegg "D10162".
- Samidorphan molecularWeight "370.441".
- Samidorphan n "2".
- Samidorphan o "4".
- Samidorphan pubchem "11667832".
- Samidorphan smiles "c1ccCN".
- Samidorphan stdinchi "1".
- Samidorphan stdinchikey "RYIDHLJADOKWFM-MAODMQOUSA-N".
- Samidorphan synonyms "ALKS-33, RDC-0313".
- Samidorphan unii "7".
- Samidorphan wikiPageUsesTemplate Template:Cascite.
- Samidorphan wikiPageUsesTemplate Template:Drugbox.
- Samidorphan wikiPageUsesTemplate Template:Fdacite.
- Samidorphan wikiPageUsesTemplate Template:Keggcite.
- Samidorphan wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Samidorphan wikiPageUsesTemplate Template:Opioidergics.
- Samidorphan wikiPageUsesTemplate Template:Reflist.
- Samidorphan subject Category:Cyclopropanes.
- Samidorphan subject Category:Ketones.
- Samidorphan subject Category:Morphinans.
- Samidorphan subject Category:Opioid_antagonists.
- Samidorphan subject Category:Synthetic_opioids.
- Samidorphan hypernym Antagonist.
- Samidorphan type ChemicalSubstance.
- Samidorphan type Drug.
- Samidorphan type Group.
- Samidorphan type Antagonist.
- Samidorphan type Chemical.
- Samidorphan type Group.
- Samidorphan type Heterocycle.
- Samidorphan type Ketone.
- Samidorphan type Opioid.
- Samidorphan type ChemicalObject.
- Samidorphan type Thing.
- Samidorphan type Q8386.
- Samidorphan comment "Samidorphan (INN, USAN) (developmental code names ALKS-33, RDC-0313), also known as 3-carboxamido-4-hydroxynaltrexone, is an opioid antagonist that selectively blocks the μ-opioid receptor, without blocking the δ-opioid or κ-opioid receptors.".
- Samidorphan label "Samidorphan".
- Samidorphan sameAs Q7409428.
- Samidorphan sameAs m.0k2fd0t.
- Samidorphan sameAs Samidorfan.
- Samidorphan sameAs Samidorfan.
- Samidorphan sameAs Q7409428.
- Samidorphan wasDerivedFrom Samidorphan?oldid=696945545.
- Samidorphan depiction Samidorphan_structure.svg.
- Samidorphan isPrimaryTopicOf Samidorphan.