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- SLUDGE_syndrome abstract "SLUDGE is a mnemonic for the pathological effects indicative of massive discharge of the parasympathetic nervous system. Unlikely to occur naturally, SLUDGE is usually encountered only in cases of drug overdose, ingestion of certain poisonous mushrooms (particularly the muscarine-containing members of the genera Inocybe and Clitocybe), or exposure to nerve gases. The symptoms of \"SLUDGE\" are due to chronic stimulation of muscarinic acetylcholine receptors, in organs and muscles innervated by the parasympathetic nervous system. It is useful to remember some of the symptoms of increased cholinergic stimulation through the mnemonic SLUDGE: Salivation: stimulation of the salivary glands Lacrimation: stimulation of the lacrimal glands (tearing) Urination: relaxation of the internal sphincter muscle of urethra, and contraction of the detrusor muscles Diaphoresis: stimulation of the sweat glands Gastrointestinal upset: Smooth muscle tone changes causing gastrointestinal problems, including diarrhea Emesis: VomitingAn extension is SLUDGEM, where the additional M indicates:Miosis: stimulation of the pupillary constrictor musclesorMuscle spasm: stimulation of skeletal muscleOne common cause of SLUDGE is exposure to organophosphorus insecticides (including parathion, malathion, and diazinon) or nerve gas, such as sarin. These agents phosphorylate acetylcholinesterase, thereby irreversibly deactivating acetylcholinesterase and raising acetylcholine levels and causing SLUDGE(M).SLUDGE may be treated with atropine, pralidoxime or other anticholinergics.".
- SLUDGE_syndrome wikiPageID "7290898".
- SLUDGE_syndrome wikiPageLength "2797".
- SLUDGE_syndrome wikiPageOutDegree "41".
- SLUDGE_syndrome wikiPageRevisionID "703286080".
- SLUDGE_syndrome wikiPageWikiLink Atropine.
- SLUDGE_syndrome wikiPageWikiLink Category:Nerve_agents.
- SLUDGE_syndrome wikiPageWikiLink Category:Symptoms.
- SLUDGE_syndrome wikiPageWikiLink Category:Toxic_effects_of_pesticides.
- SLUDGE_syndrome wikiPageWikiLink Cholinergic.
- SLUDGE_syndrome wikiPageWikiLink Clitocybe.
- SLUDGE_syndrome wikiPageWikiLink Detrusor_urinae_muscle.
- SLUDGE_syndrome wikiPageWikiLink Diarrhea.
- SLUDGE_syndrome wikiPageWikiLink Diazinon.
- SLUDGE_syndrome wikiPageWikiLink Gastrointestinal_disease.
- SLUDGE_syndrome wikiPageWikiLink Inocybe.
- SLUDGE_syndrome wikiPageWikiLink Internal_sphincter_muscle_of_urethra.
- SLUDGE_syndrome wikiPageWikiLink Iris_sphincter_muscle.
- SLUDGE_syndrome wikiPageWikiLink Lacrimal_gland.
- SLUDGE_syndrome wikiPageWikiLink Malathion.
- SLUDGE_syndrome wikiPageWikiLink Miosis.
- SLUDGE_syndrome wikiPageWikiLink Mnemonic.
- SLUDGE_syndrome wikiPageWikiLink Muscarine.
- SLUDGE_syndrome wikiPageWikiLink Muscarinic_acetylcholine_receptor.
- SLUDGE_syndrome wikiPageWikiLink Mushroom.
- SLUDGE_syndrome wikiPageWikiLink Mushroom_poisoning.
- SLUDGE_syndrome wikiPageWikiLink Nausea.
- SLUDGE_syndrome wikiPageWikiLink Nerve_agent.
- SLUDGE_syndrome wikiPageWikiLink Organophosphate.
- SLUDGE_syndrome wikiPageWikiLink Parasympathetic_nervous_system.
- SLUDGE_syndrome wikiPageWikiLink Parathion.
- SLUDGE_syndrome wikiPageWikiLink Perspiration.
- SLUDGE_syndrome wikiPageWikiLink Phosphorylation.
- SLUDGE_syndrome wikiPageWikiLink Pralidoxime.
- SLUDGE_syndrome wikiPageWikiLink Saliva.
- SLUDGE_syndrome wikiPageWikiLink Salivary_gland.
- SLUDGE_syndrome wikiPageWikiLink Sarin.
- SLUDGE_syndrome wikiPageWikiLink Skeletal_muscle.
- SLUDGE_syndrome wikiPageWikiLink Smooth_muscle_tissue.
- SLUDGE_syndrome wikiPageWikiLink Spasm.
- SLUDGE_syndrome wikiPageWikiLink Sweat_gland.
- SLUDGE_syndrome wikiPageWikiLink Symptom.
- SLUDGE_syndrome wikiPageWikiLink Tears.
- SLUDGE_syndrome wikiPageWikiLink Urination.
- SLUDGE_syndrome wikiPageWikiLink Vomiting.
- SLUDGE_syndrome wikiPageWikiLinkText "SLUDGE syndrome".
- SLUDGE_syndrome wikiPageWikiLinkText "SLUDGE".
- SLUDGE_syndrome wikiPageWikiLinkText "SLUDGEM".
- SLUDGE_syndrome wikiPageUsesTemplate Template:Refimprove.
- SLUDGE_syndrome wikiPageUsesTemplate Template:Reflist.
- SLUDGE_syndrome subject Category:Nerve_agents.
- SLUDGE_syndrome subject Category:Symptoms.
- SLUDGE_syndrome subject Category:Toxic_effects_of_pesticides.
- SLUDGE_syndrome type Agent.
- SLUDGE_syndrome type Agent.
- SLUDGE_syndrome type Effect.
- SLUDGE_syndrome type Pesticide.
- SLUDGE_syndrome comment "SLUDGE is a mnemonic for the pathological effects indicative of massive discharge of the parasympathetic nervous system. Unlikely to occur naturally, SLUDGE is usually encountered only in cases of drug overdose, ingestion of certain poisonous mushrooms (particularly the muscarine-containing members of the genera Inocybe and Clitocybe), or exposure to nerve gases.".
- SLUDGE_syndrome label "SLUDGE syndrome".
- SLUDGE_syndrome sameAs Q7391005.
- SLUDGE_syndrome sameAs m.025yc7f.
- SLUDGE_syndrome sameAs Q7391005.
- SLUDGE_syndrome wasDerivedFrom SLUDGE_syndrome?oldid=703286080.
- SLUDGE_syndrome isPrimaryTopicOf SLUDGE_syndrome.