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- SECIS_element abstract "In biology, the SECIS element (SECIS: selenocysteine insertion sequence) is an RNA element around 60 nucleotides in length that adopts a stem-loop structure. This structural motif (pattern of nucleotides) directs the cell to translate UGA codons as selenocysteines. (UGA is normally a stop codon.) SECIS elements are thus a fundamental aspect of messenger RNAs encoding selenoproteins, proteins that include one or more selenocysteine residues.In bacteria the SECIS element appears soon after the UGA codon it affects. In archaea and eukaryotes, it occurs in the 3' UTR of an mRNA, and can cause multiple UGA codons within the mRNA to code for selenocysteine. One archaeal SECIS element, in Methanococcus, is located in the 5' UTR.The SECIS element appears defined by sequence characteristics, i.e. particular nucleotides tend to be at particular positions in it, and a characteristic secondary structure. The secondary structure is the result of base-pairing of complementary RNA nucleotides, and causes a hairpin-like structure. The eukaryotic SECIS element includes non-canonical A-G base pairs, which are uncommon in nature, but are critically important for correct SECIS element function. Although the eukaryotic, archaeal and bacterial SECIS elements each share a general hairpin structure, they are not alignable, e.g. an alignment-based scheme to recognize eukaryotic SECIS elements will not be able to recognize archaeal SECIS elements.In bioinformatics, several computer programs have been created that search for SECIS elements within a genome sequence, based on the sequence and secondary structure characteristics of SECIS elements. These programs have been used in searches for novel selenoproteins.".
- SECIS_element thumbnail RF00031.jpg?width=300.
- SECIS_element wikiPageID "345929".
- SECIS_element wikiPageLength "5574".
- SECIS_element wikiPageOutDegree "30".
- SECIS_element wikiPageRevisionID "679038482".
- SECIS_element wikiPageWikiLink Archaea.
- SECIS_element wikiPageWikiLink Bacteria.
- SECIS_element wikiPageWikiLink Bioinformatics.
- SECIS_element wikiPageWikiLink Biology.
- SECIS_element wikiPageWikiLink Biomolecular_structure.
- SECIS_element wikiPageWikiLink Category:Cis-regulatory_RNA_elements.
- SECIS_element wikiPageWikiLink Category:Gene_expression.
- SECIS_element wikiPageWikiLink Cell_(biology).
- SECIS_element wikiPageWikiLink Cis-Regulatory_element.
- SECIS_element wikiPageWikiLink Conserved_sequence.
- SECIS_element wikiPageWikiLink Eukaryote.
- SECIS_element wikiPageWikiLink Five_prime_untranslated_region.
- SECIS_element wikiPageWikiLink Genetic_code.
- SECIS_element wikiPageWikiLink Genome.
- SECIS_element wikiPageWikiLink Messenger_RNA.
- SECIS_element wikiPageWikiLink Methanococcus.
- SECIS_element wikiPageWikiLink Nucleotide.
- SECIS_element wikiPageWikiLink RNA.
- SECIS_element wikiPageWikiLink Selenocysteine.
- SECIS_element wikiPageWikiLink Selenoprotein.
- SECIS_element wikiPageWikiLink Stem-loop.
- SECIS_element wikiPageWikiLink Stop_codon.
- SECIS_element wikiPageWikiLink Structural_motif.
- SECIS_element wikiPageWikiLink Three_prime_untranslated_region.
- SECIS_element wikiPageWikiLink Translation_(biology).
- SECIS_element wikiPageWikiLink Wobble_base_pair.
- SECIS_element wikiPageWikiLinkText "SECIS element".
- SECIS_element wikiPageWikiLinkText "SECIS".
- SECIS_element wikiPageWikiLinkText "Selenocysteine insertion sequence".
- SECIS_element wikiPageWikiLinkText "selenocysteine insertion sequence".
- SECIS_element wikiPageWikiLinkText "selenocysteine insertion sequence(SECIS)".
- SECIS_element altsymbols "SECIS".
- SECIS_element caption "Predicted secondary structure and sequence conservation of SECIS_1".
- SECIS_element id "RF00031".
- SECIS_element id "RF01988".
- SECIS_element id "RF01989".
- SECIS_element id "RF01990".
- SECIS_element id "RF01991".
- SECIS_element name "SECIS element 1".
- SECIS_element name "SECIS element 2".
- SECIS_element name "SECIS element 3".
- SECIS_element name "SECIS element 4".
- SECIS_element name "SECIS element 5".
- SECIS_element name "Selenocysteine insertion sequence 1".
- SECIS_element rfam "RF00031".
- SECIS_element rnaType Cis-Regulatory_element.
- SECIS_element symbol "SECIS_1".
- SECIS_element taxDomain Eukaryote.
- SECIS_element wikiPageUsesTemplate Template:Citation_needed.
- SECIS_element wikiPageUsesTemplate Template:GO.
- SECIS_element wikiPageUsesTemplate Template:Infobox_rfam.
- SECIS_element wikiPageUsesTemplate Template:Reflist.
- SECIS_element wikiPageUsesTemplate Template:Rfam.
- SECIS_element wikiPageUsesTemplate Template:SO.
- SECIS_element subject Category:Cis-regulatory_RNA_elements.
- SECIS_element subject Category:Gene_expression.
- SECIS_element hypernym Element.
- SECIS_element type MilitaryUnit.
- SECIS_element type Element.
- SECIS_element type Process.
- SECIS_element comment "In biology, the SECIS element (SECIS: selenocysteine insertion sequence) is an RNA element around 60 nucleotides in length that adopts a stem-loop structure. This structural motif (pattern of nucleotides) directs the cell to translate UGA codons as selenocysteines.".
- SECIS_element label "SECIS element".
- SECIS_element sameAs Q3130206.
- SECIS_element sameAs Element_SECIS.
- SECIS_element sameAs SECIS-element.
- SECIS_element sameAs Élément_SECIS.
- SECIS_element sameAs Elemento_SECIS.
- SECIS_element sameAs m.01yqd_.
- SECIS_element sameAs SECIS-элемент.
- SECIS_element sameAs Q3130206.
- SECIS_element wasDerivedFrom SECIS_element?oldid=679038482.
- SECIS_element depiction RF00031.jpg.
- SECIS_element isPrimaryTopicOf SECIS_element.