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- SCNN1G abstract "The SCNN1G gene encodes for the γ subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1A, SCNN1B, and SCNN1D.ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons. The abbreviation for the genes encoding for voltage-gated sodium channel starts with three letters: SCN. In contrast to these sodium channels, ENaC is constitutively active and is not voltage-dependent. The second N in the abbreviation (SCNN1) represents that these are NON-voltage-gated channels.In most vertebrates, sodium ions are the major determinant of the osmolarity of the extracellular fluid. ENaC allows transfer of sodium ions across the epithelial cell membrane in so-called \"tight-epithelia\" that have low permeability. The flow of sodium ions across epithelia affects osmolarity of the extracellular fluid. Thus, ENaC plays a central role in the regulation of body fluid and electrolyte homeostasis and consequently affects blood pressure.As ENaC is strongly inhibited by amiloride, it is also referred to as an \"amiloride-sensitive sodium channel\".".
- SCNN1G entrezgene "6340".
- SCNN1G thumbnail SCNN1G-gene-transcript-Hanukoglu.png?width=300.
- SCNN1G wikiPageExternalLink Compara_Tree?db=core;g=ENSG00000168447;r=16:23278231-23381299.
- SCNN1G wikiPageExternalLink Summary?db=core;g=ENSG00000166828;r=16:23182715-23216883;t=ENST00000300061.
- SCNN1G wikiPageID "14754728".
- SCNN1G wikiPageLength "25832".
- SCNN1G wikiPageOutDegree "15".
- SCNN1G wikiPageRevisionID "701735121".
- SCNN1G wikiPageWikiLink Amiloride.
- SCNN1G wikiPageWikiLink Category:Ion_channels.
- SCNN1G wikiPageWikiLink Epithelial_sodium_channel.
- SCNN1G wikiPageWikiLink NEDD4.
- SCNN1G wikiPageWikiLink Protein–protein_interaction.
- SCNN1G wikiPageWikiLink SCNN1A.
- SCNN1G wikiPageWikiLink SCNN1B.
- SCNN1G wikiPageWikiLink SCNN1D.
- SCNN1G wikiPageWikiLink STX1A.
- SCNN1G wikiPageWikiLink Ubiquitin.
- SCNN1G wikiPageWikiLink Ubiquitin_C.
- SCNN1G wikiPageWikiLink File:SCNN1G-gene-transcript-Hanukoglu.png.
- SCNN1G wikiPageWikiLinkText "SCNN1G".
- SCNN1G wikiPageUsesTemplate Template:Cite_journal.
- SCNN1G wikiPageUsesTemplate Template:Clear.
- SCNN1G wikiPageUsesTemplate Template:Ion_channels.
- SCNN1G wikiPageUsesTemplate Template:MeshName.
- SCNN1G wikiPageUsesTemplate Template:PBB.
- SCNN1G wikiPageUsesTemplate Template:Refbegin.
- SCNN1G wikiPageUsesTemplate Template:Refend.
- SCNN1G wikiPageUsesTemplate Template:Reflist.
- SCNN1G subject Category:Ion_channels.
- SCNN1G type Biomolecule.
- SCNN1G type Protein.
- SCNN1G type Biophysic.
- SCNN1G type Channel.
- SCNN1G type Thing.
- SCNN1G type Q206229.
- SCNN1G type Q8054.
- SCNN1G comment "The SCNN1G gene encodes for the γ subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1A, SCNN1B, and SCNN1D.ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons.".
- SCNN1G label "SCNN1G".
- SCNN1G sameAs Q18031405.
- SCNN1G sameAs m.03gwrmx.
- SCNN1G sameAs Q18031405.
- SCNN1G wasDerivedFrom SCNN1G?oldid=701735121.
- SCNN1G depiction SCNN1G-gene-transcript-Hanukoglu.png.
- SCNN1G isPrimaryTopicOf SCNN1G.