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- SB-271046 abstract "SB-271046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found through high-throughput screening of the SmithKline Beecham Compound Bank using cloned 5-HT6 receptors as a target, with an initial lead compound being developed into SB-271046 through a structure-activity relationship (SAR) study. SB-271046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the blood–brain barrier, so further SAR work was then conducted, which led to improved 5-HT6 antagonists such as SB-357,134 and SB-399,885.SB-271046 was found to increase levels of the excitatory amino acid neurotransmitters glutamate and aspartate, as well as dopamine and noradrenaline in the frontal cortex and hippocampus of rats, and 5-HT6 antagonists have been shown to produce nootropic effects in a variety of animal studies. Suggested applications of these drugs include treatment of schizophrenia and other psychiatric disorders.".
- SB-271046 iupacName "5-chloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-1-benzothiophene-2-sulfonamide".
- SB-271046 pubchem "5312149".
- SB-271046 thumbnail SB-271,046_structure.png?width=300.
- SB-271046 wikiPageID "19999911".
- SB-271046 wikiPageLength "9515".
- SB-271046 wikiPageOutDegree "27".
- SB-271046 wikiPageRevisionID "706834906".
- SB-271046 wikiPageWikiLink 5-HT6_receptor.
- SB-271046 wikiPageWikiLink Amino_acid.
- SB-271046 wikiPageWikiLink Aspartic_acid.
- SB-271046 wikiPageWikiLink Blood–brain_barrier.
- SB-271046 wikiPageWikiLink Category:5-HT6_antagonists.
- SB-271046 wikiPageWikiLink Category:Benzothiophenes.
- SB-271046 wikiPageWikiLink Category:Chloroarenes.
- SB-271046 wikiPageWikiLink Category:Phenol_ethers.
- SB-271046 wikiPageWikiLink Category:Piperazines.
- SB-271046 wikiPageWikiLink Category:Sulfonamides.
- SB-271046 wikiPageWikiLink Dopamine.
- SB-271046 wikiPageWikiLink Frontal_lobe.
- SB-271046 wikiPageWikiLink GlaxoSmithKline.
- SB-271046 wikiPageWikiLink Glutamic_acid.
- SB-271046 wikiPageWikiLink High-throughput_screening.
- SB-271046 wikiPageWikiLink Hippocampus.
- SB-271046 wikiPageWikiLink In_vitro.
- SB-271046 wikiPageWikiLink In_vivo.
- SB-271046 wikiPageWikiLink Neurotransmitter.
- SB-271046 wikiPageWikiLink Nootropic.
- SB-271046 wikiPageWikiLink Norepinephrine.
- SB-271046 wikiPageWikiLink Receptor_(biochemistry).
- SB-271046 wikiPageWikiLink Receptor_antagonist.
- SB-271046 wikiPageWikiLink SB-357134.
- SB-271046 wikiPageWikiLink SB-399885.
- SB-271046 wikiPageWikiLink Schizophrenia.
- SB-271046 wikiPageWikiLink Structure–activity_relationship.
- SB-271046 wikiPageWikiLinkText "SB-271046".
- SB-271046 c "20".
- SB-271046 chembl "431298".
- SB-271046 chemspiderid "4471579".
- SB-271046 cl "1".
- SB-271046 h "22".
- SB-271046 inchi "1".
- SB-271046 inchikey "LOCQRDBFWSXQQI-UHFFFAOYAF".
- SB-271046 iupacName "5".
- SB-271046 iupharLigand "276".
- SB-271046 molecularWeight "451.989".
- SB-271046 n "3".
- SB-271046 o "3".
- SB-271046 pubchem "5312149".
- SB-271046 s "2".
- SB-271046 smiles "C4CNCCN4c3ccNSc1sc2ccccc2c1C".
- SB-271046 stdinchi "1".
- SB-271046 stdinchikey "LOCQRDBFWSXQQI-UHFFFAOYSA-N".
- SB-271046 verifiedfields "changed".
- SB-271046 verifiedrevid "407719655".
- SB-271046 width "240".
- SB-271046 wikiPageUsesTemplate Template:Cascite.
- SB-271046 wikiPageUsesTemplate Template:Chemspidercite.
- SB-271046 wikiPageUsesTemplate Template:Drugbox.
- SB-271046 wikiPageUsesTemplate Template:Ebicite.
- SB-271046 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- SB-271046 wikiPageUsesTemplate Template:Piperazines.
- SB-271046 wikiPageUsesTemplate Template:Reflist.
- SB-271046 wikiPageUsesTemplate Template:Serotonergics.
- SB-271046 wikiPageUsesTemplate Template:Stdinchicite.
- SB-271046 subject Category:5-HT6_antagonists.
- SB-271046 subject Category:Benzothiophenes.
- SB-271046 subject Category:Chloroarenes.
- SB-271046 subject Category:Phenol_ethers.
- SB-271046 subject Category:Piperazines.
- SB-271046 subject Category:Sulfonamides.
- SB-271046 hypernym Drug.
- SB-271046 type ChemicalSubstance.
- SB-271046 type Drug.
- SB-271046 type Amide.
- SB-271046 type Antagonist.
- SB-271046 type Chemical.
- SB-271046 type Drug.
- SB-271046 type Ether.
- SB-271046 type Heterocycle.
- SB-271046 type Organohalide.
- SB-271046 type Sulfonamide.
- SB-271046 type Organohalide.
- SB-271046 type ChemicalObject.
- SB-271046 type Thing.
- SB-271046 type Q8386.
- SB-271046 comment "SB-271046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found through high-throughput screening of the SmithKline Beecham Compound Bank using cloned 5-HT6 receptors as a target, with an initial lead compound being developed into SB-271046 through a structure-activity relationship (SAR) study.".
- SB-271046 label "SB-271046".
- SB-271046 sameAs Q855568.
- SB-271046 sameAs SB-271,046.
- SB-271046 sameAs m.04y9kf9.
- SB-271046 sameAs SB-271,046.
- SB-271046 sameAs SB-271,046.
- SB-271046 sameAs Q855568.
- SB-271046 wasDerivedFrom SB-271046?oldid=706834906.
- SB-271046 depiction SB-271,046_structure.png.
- SB-271046 isPrimaryTopicOf SB-271046.