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- SB-236057 abstract "SB-236057 is a compound which is a potent and selective inverse agonist for the serotonin receptor 5-HT1B, acting especially at 5-HT1B autoreceptors on nerve terminals. It produces a rapid increase in serotonin levels in the brain, and was originally researched as a potential antidepressant. However subsequent research found that SB-236,057 also acts as a potent teratogen, producing severe musculoskeletal birth defects when rodents were exposed to it during pregnancy. This has made it little used for research into its original applications, but has made it useful for studying embryonic development instead.".
- SB-236057 atcPrefix "none".
- SB-236057 casNumber "180083-49-2".
- SB-236057 iupacName "1'-ethyl-5-[2'-methyl-4'-(5-methyl-1,3,4-oxadiazolyl-2-yl)biphenyl-4-carbonyl]-2,3,6,7-tetrahydrospiro(furo[2,3-f]indole-3,4'-piperidine)".
- SB-236057 pubchem "5311426".
- SB-236057 thumbnail SB236057_structure.png?width=300.
- SB-236057 wikiPageID "44500893".
- SB-236057 wikiPageLength "2770".
- SB-236057 wikiPageOutDegree "11".
- SB-236057 wikiPageRevisionID "667227472".
- SB-236057 wikiPageWikiLink 5-HT1B_receptor.
- SB-236057 wikiPageWikiLink Antidepressant.
- SB-236057 wikiPageWikiLink Binding_selectivity.
- SB-236057 wikiPageWikiLink Category:5-HT1B_antagonists.
- SB-236057 wikiPageWikiLink Category:Oxadiazoles.
- SB-236057 wikiPageWikiLink Category:Teratogens.
- SB-236057 wikiPageWikiLink Inverse_agonist.
- SB-236057 wikiPageWikiLink Receptor_(biochemistry).
- SB-236057 wikiPageWikiLink Serotonin.
- SB-236057 wikiPageWikiLink Teratology.
- SB-236057 wikiPageWikiLinkText "SB-236057".
- SB-236057 atcPrefix "none".
- SB-236057 c "33".
- SB-236057 casNumber "180083".
- SB-236057 h "34".
- SB-236057 iupacName "1".
- SB-236057 iupharLigand "3231".
- SB-236057 molecularWeight "534.647".
- SB-236057 n "4".
- SB-236057 o "3".
- SB-236057 pubchem "5311426".
- SB-236057 smiles "n5ncoc5-cccc2-c6cccCNc1cc3C7CCN4CC".
- SB-236057 wikiPageUsesTemplate Template:Cascite.
- SB-236057 wikiPageUsesTemplate Template:Drugbox.
- SB-236057 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- SB-236057 wikiPageUsesTemplate Template:Reflist.
- SB-236057 wikiPageUsesTemplate Template:Serotonergics.
- SB-236057 subject Category:5-HT1B_antagonists.
- SB-236057 subject Category:Oxadiazoles.
- SB-236057 subject Category:Teratogens.
- SB-236057 hypernym Compound.
- SB-236057 type ChemicalCompound.
- SB-236057 type ChemicalSubstance.
- SB-236057 type Drug.
- SB-236057 type ChemicalObject.
- SB-236057 type Thing.
- SB-236057 type Q8386.
- SB-236057 comment "SB-236057 is a compound which is a potent and selective inverse agonist for the serotonin receptor 5-HT1B, acting especially at 5-HT1B autoreceptors on nerve terminals. It produces a rapid increase in serotonin levels in the brain, and was originally researched as a potential antidepressant. However subsequent research found that SB-236,057 also acts as a potent teratogen, producing severe musculoskeletal birth defects when rodents were exposed to it during pregnancy.".
- SB-236057 label "SB-236057".
- SB-236057 sameAs Q21098842.
- SB-236057 sameAs m.012c5lxr.
- SB-236057 sameAs Q21098842.
- SB-236057 wasDerivedFrom SB-236057?oldid=667227472.
- SB-236057 depiction SB236057_structure.png.
- SB-236057 isPrimaryTopicOf SB-236057.