Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/S32212> ?p ?o }
- S32212 abstract "S32212 is a drug which is under preclinical investigation as a potential antidepressant medicine. It behaves as a selective, combined 5-HT2C receptor inverse agonist and α2-adrenergic receptor antagonist (at all three subtypes—α2A, α2B, and α2C) with additional 5-HT2A and, to a lesser extent, 5-HT2B receptor antagonistic properties, and lacks any apparent affinity for the monoamine reuptake transporters or for the α1-adrenergic, H1, or mACh receptors. This profile of activity is compatible with the definition of a noradrenergic and specific serotonergic antidepressant (NaSSA), and as such, S32212 could in turn be classified as a NaSSA if it reaches the market.In animal studies, S32212 raised BDNF concentrations in the hippocampus and amygdala, increased the firing rate of neurons in the adrenergic perikarya in the locus coeruleus, increased levels of norepinephrine in the frontal cortex and hippocampus, and elevated frontal cortex levels of dopamine and acetylcholine, though not of serotonin or histamine. It produces effects indicative of antidepressant, anxiolytic, antiobsessional, antiaggressive, and cognitive- and sleep-enhancing properties in animal models, all while not perturbing body weight or sexual behavior.".
- S32212 atcPrefix "None".
- S32212 iupacName "N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-1,2-dihydro-3H-benzo[e]indole-3-carboxamide".
- S32212 pubchem "11384503".
- S32212 thumbnail S32212.svg?width=300.
- S32212 wikiPageID "35599329".
- S32212 wikiPageLength "4534".
- S32212 wikiPageOutDegree "48".
- S32212 wikiPageRevisionID "683906465".
- S32212 wikiPageWikiLink 5-HT2A_receptor.
- S32212 wikiPageWikiLink 5-HT2B_receptor.
- S32212 wikiPageWikiLink 5-HT2C_receptor.
- S32212 wikiPageWikiLink Acetylcholine.
- S32212 wikiPageWikiLink Alpha-1_adrenergic_receptor.
- S32212 wikiPageWikiLink Alpha-2A_adrenergic_receptor.
- S32212 wikiPageWikiLink Alpha-2B_adrenergic_receptor.
- S32212 wikiPageWikiLink Alpha-2C_adrenergic_receptor.
- S32212 wikiPageWikiLink Alpha-2_adrenergic_receptor.
- S32212 wikiPageWikiLink Amygdala.
- S32212 wikiPageWikiLink Antidepressant.
- S32212 wikiPageWikiLink Anxiolytic.
- S32212 wikiPageWikiLink Binding_selectivity.
- S32212 wikiPageWikiLink Brain-derived_neurotrophic_factor.
- S32212 wikiPageWikiLink Category:Alpha-2_blockers.
- S32212 wikiPageWikiLink Category:Carboxamides.
- S32212 wikiPageWikiLink Category:Indoles.
- S32212 wikiPageWikiLink Category:Noradrenergic_and_specific_serotonergic_antidepressants.
- S32212 wikiPageWikiLink Category:Piperazines.
- S32212 wikiPageWikiLink Category:Serotonin_antagonists.
- S32212 wikiPageWikiLink Dopamine.
- S32212 wikiPageWikiLink Drug.
- S32212 wikiPageWikiLink Frontal_lobe.
- S32212 wikiPageWikiLink Hippocampus.
- S32212 wikiPageWikiLink Histamine.
- S32212 wikiPageWikiLink Histamine_H1_receptor.
- S32212 wikiPageWikiLink Human_body_weight.
- S32212 wikiPageWikiLink Human_sexuality.
- S32212 wikiPageWikiLink Hypnotic.
- S32212 wikiPageWikiLink Inverse_agonist.
- S32212 wikiPageWikiLink Ligand_(biochemistry).
- S32212 wikiPageWikiLink Locus_coeruleus.
- S32212 wikiPageWikiLink Medicine.
- S32212 wikiPageWikiLink Model_organism.
- S32212 wikiPageWikiLink Monoamine_transporter.
- S32212 wikiPageWikiLink Muscarinic_acetylcholine_receptor.
- S32212 wikiPageWikiLink Neuron.
- S32212 wikiPageWikiLink Nootropic.
- S32212 wikiPageWikiLink Noradrenergic_and_specific_serotonergic_antidepressant.
- S32212 wikiPageWikiLink Norepinephrine.
- S32212 wikiPageWikiLink Pre-clinical_development.
- S32212 wikiPageWikiLink Receptor_antagonist.
- S32212 wikiPageWikiLink Serenic.
- S32212 wikiPageWikiLink Serotonin.
- S32212 wikiPageWikiLink Soma_(biology).
- S32212 wikiPageWikiLinkText "S32212".
- S32212 atcPrefix "None".
- S32212 c "25".
- S32212 chemspiderid "9559416".
- S32212 h "28".
- S32212 image "S32212 ball-and-stick model.png".
- S32212 inchi "1".
- S32212 inchikey "HNWBOBAUHUFDES-UHFFFAOYAA".
- S32212 iupacName "N-[4-methoxy-3-phenyl]-1,2-dihydro-3H-benzo[e]indole-3-carboxamide".
- S32212 molecularWeight "416.515".
- S32212 n "4".
- S32212 o "2".
- S32212 pubchem "11384503".
- S32212 smiles "O=CNc4ccN5CCNCC5".
- S32212 stdinchi "1".
- S32212 stdinchikey "HNWBOBAUHUFDES-UHFFFAOYSA-N".
- S32212 width "275".
- S32212 wikiPageUsesTemplate Template:Adrenergics.
- S32212 wikiPageUsesTemplate Template:Antidepressants.
- S32212 wikiPageUsesTemplate Template:Drugbox.
- S32212 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- S32212 wikiPageUsesTemplate Template:Piperazines.
- S32212 wikiPageUsesTemplate Template:Reflist.
- S32212 wikiPageUsesTemplate Template:Serotonergics.
- S32212 subject Category:Alpha-2_blockers.
- S32212 subject Category:Carboxamides.
- S32212 subject Category:Indoles.
- S32212 subject Category:Noradrenergic_and_specific_serotonergic_antidepressants.
- S32212 subject Category:Piperazines.
- S32212 subject Category:Serotonin_antagonists.
- S32212 hypernym Drug.
- S32212 type ChemicalSubstance.
- S32212 type Drug.
- S32212 type Amide.
- S32212 type Antagonist.
- S32212 type Antidepressant.
- S32212 type Carboxamide.
- S32212 type Chemical.
- S32212 type Drug.
- S32212 type Heterocycle.
- S32212 type ChemicalObject.
- S32212 type Thing.
- S32212 type Q8386.
- S32212 comment "S32212 is a drug which is under preclinical investigation as a potential antidepressant medicine. It behaves as a selective, combined 5-HT2C receptor inverse agonist and α2-adrenergic receptor antagonist (at all three subtypes—α2A, α2B, and α2C) with additional 5-HT2A and, to a lesser extent, 5-HT2B receptor antagonistic properties, and lacks any apparent affinity for the monoamine reuptake transporters or for the α1-adrenergic, H1, or mACh receptors.".
- S32212 label "S32212".
- S32212 sameAs Q7388266.