Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Rosiglitazone> ?p ?o }
- Rosiglitazone abstract "Rosiglitazone (trade name Avandia, GlaxoSmithKline) is an antidiabetic drug in the thiazolidinedione class of drugs. It works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride. First released in 1999, annual sales peaked at approximately $2.5-billion in 2006; however, following a meta-analysis published in the New England Journal of Medicine in 2007 that linked the drug's use to an increased risk of heart attack, sales plummeted to just $9.5-million in 2012. The drug's patent expired in 2012.Despite rosiglitazone's effectiveness at decreasing blood sugar in type 2 diabetes mellitus, its use decreased dramatically as studies showed apparent associations with increased risks of heart attacks and death. Adverse effects alleged to be caused by rosiglitazone were the subject of over 13,000 lawsuits against GSK; as of July 2010, GSK had agreed to settlements on more than 11,500 of these suits.Some reviewers recommended rosiglitazone be taken off the market, but an FDA panel disagreed, and it remains available in the U.S. From November 2011 until November 2013, the federal government did not allow Avandia to be sold without a prescription from a certified doctor; moreover, patients were required to be informed of the risks associated with its use, and the drug had to be purchased by mail order through specified pharmacies. In November 2013, the FDA lifted its earlier restrictions on rosiglitazone after reviewing the results of the 2009 RECORD clinical trial (a six-year, open label randomized control trial), which failed to show heart infarct risks associated with the drug.In Europe, the European Medicines Agency (EMA) recommended in September 2010 that the drug be suspended from the European market because the benefits of rosiglitazone no longer outweighed the risks. It was withdrawn from the market in the UK and India in 2010, and in New Zealand and South Africa in 2011.".
- Rosiglitazone atcPrefix "A10".
- Rosiglitazone atcSuffix "BG02".
- Rosiglitazone bioavailability "99.0".
- Rosiglitazone casNumber "122320-73-4".
- Rosiglitazone chEBI "50122".
- Rosiglitazone drugbank "DB00412".
- Rosiglitazone fdaUniiCode "05V02F2KDG".
- Rosiglitazone iupacName "(RS)-5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione".
- Rosiglitazone pubchem "77999".
- Rosiglitazone thumbnail Rosiglitazone.svg?width=300.
- Rosiglitazone wikiPageExternalLink dpdirect.jsp?name=Rosiglitazone.
- Rosiglitazone wikiPageExternalLink www.avandia.com.
- Rosiglitazone wikiPageExternalLink ?ligand=BRL.
- Rosiglitazone wikiPageExternalLink ?ligand=RGZ.
- Rosiglitazone wikiPageExternalLink 483837.
- Rosiglitazone wikiPageExternalLink a699023.html.
- Rosiglitazone wikiPageID "604046".
- Rosiglitazone wikiPageLength "53737".
- Rosiglitazone wikiPageOutDegree "68".
- Rosiglitazone wikiPageRevisionID "707073131".
- Rosiglitazone wikiPageWikiLink Allele.
- Rosiglitazone wikiPageWikiLink Alzheimers_disease.
- Rosiglitazone wikiPageWikiLink American_Association_of_Clinical_Endocrinologists.
- Rosiglitazone wikiPageWikiLink American_Diabetes_Association.
- Rosiglitazone wikiPageWikiLink American_Heart_Association.
- Rosiglitazone wikiPageWikiLink Annals_of_Internal_Medicine.
- Rosiglitazone wikiPageWikiLink Anti-diabetic_medication.
- Rosiglitazone wikiPageWikiLink Apolipoprotein_E.
- Rosiglitazone wikiPageWikiLink Avandaryl.
- Rosiglitazone wikiPageWikiLink Boxed_warning.
- Rosiglitazone wikiPageWikiLink CYP2C8.
- Rosiglitazone wikiPageWikiLink Category:Phenol_ethers.
- Rosiglitazone wikiPageWikiLink Category:Pyridines.
- Rosiglitazone wikiPageWikiLink Category:Thiazolidinediones.
- Rosiglitazone wikiPageWikiLink Category:Withdrawn_drugs.
- Rosiglitazone wikiPageWikiLink Chuck_Grassley.
- Rosiglitazone wikiPageWikiLink Cochrane_(organisation).
- Rosiglitazone wikiPageWikiLink Diabetes_mellitus_type_2.
- Rosiglitazone wikiPageWikiLink Endocrine_Society.
- Rosiglitazone wikiPageWikiLink European_Medicines_Agency.
- Rosiglitazone wikiPageWikiLink Food_and_Drug_Administration.
- Rosiglitazone wikiPageWikiLink Fracture.
- Rosiglitazone wikiPageWikiLink GlaxoSmithKline.
- Rosiglitazone wikiPageWikiLink Glibenclamide.
- Rosiglitazone wikiPageWikiLink Glimepiride.
- Rosiglitazone wikiPageWikiLink Inflammation.
- Rosiglitazone wikiPageWikiLink Insulin.
- Rosiglitazone wikiPageWikiLink Insulin_resistance.
- Rosiglitazone wikiPageWikiLink Kidney.
- Rosiglitazone wikiPageWikiLink Liver.
- Rosiglitazone wikiPageWikiLink Macular_edema.
- Rosiglitazone wikiPageWikiLink Max_Baucus.
- Rosiglitazone wikiPageWikiLink Medsafe.
- Rosiglitazone wikiPageWikiLink Meta-analysis.
- Rosiglitazone wikiPageWikiLink Metformin.
- Rosiglitazone wikiPageWikiLink Myocardial_infarction.
- Rosiglitazone wikiPageWikiLink NF-κB.
- Rosiglitazone wikiPageWikiLink New_York_Heart_Association_Functional_Classification.
- Rosiglitazone wikiPageWikiLink Number_needed_to_harm.
- Rosiglitazone wikiPageWikiLink Peroxisome_proliferator-activated_receptor.
- Rosiglitazone wikiPageWikiLink Peroxisome_proliferator-activated_receptor_gamma.
- Rosiglitazone wikiPageWikiLink Pioglitazone.
- Rosiglitazone wikiPageWikiLink Protein_Data_Bank.
- Rosiglitazone wikiPageWikiLink Racemic_mixture.
- Rosiglitazone wikiPageWikiLink Randomized_controlled_trial.
- Rosiglitazone wikiPageWikiLink Rosiglitazone.
- Rosiglitazone wikiPageWikiLink Santa_Clara_County,_California.
- Rosiglitazone wikiPageWikiLink Sulfonylurea.
- Rosiglitazone wikiPageWikiLink The_BMJ.
- Rosiglitazone wikiPageWikiLink The_New_England_Journal_of_Medicine.
- Rosiglitazone wikiPageWikiLink Thiazolidinedione.
- Rosiglitazone wikiPageWikiLink Ulcerative_colitis.
- Rosiglitazone wikiPageWikiLink United_States_Senate_Committee_on_Finance.
- Rosiglitazone wikiPageWikiLink File:Avandia_2mg_oral_tablet.jpg.
- Rosiglitazone wikiPageWikiLink File:Rosiglitazone_synthesis.png.
- Rosiglitazone wikiPageWikiLinkText "Avandia".
- Rosiglitazone wikiPageWikiLinkText "Rosiglitazone".
- Rosiglitazone wikiPageWikiLinkText "rosiglitazone".
- Rosiglitazone atcPrefix "A10".
- Rosiglitazone atcSuffix "BG02".
- Rosiglitazone bioavailability "99.0".
- Rosiglitazone c "18".
- Rosiglitazone casNumber "122320".
- Rosiglitazone chebi "50122".
- Rosiglitazone chembl "121".
- Rosiglitazone chemspiderid "70383".
- Rosiglitazone chirality Racemic_mixture.
- Rosiglitazone drugbank "DB00412".
- Rosiglitazone eliminationHalfLife "-14400.0".
- Rosiglitazone excretion "Renal and fecal".
- Rosiglitazone h "19".
- Rosiglitazone image "Rosiglitazone ball-and-stick.png".
- Rosiglitazone inchi "1".
- Rosiglitazone inchikey "YASAKCUCGLMORW-UHFFFAOYAR".
- Rosiglitazone iupacName "-5".
- Rosiglitazone iupharLigand "1056".
- Rosiglitazone kegg "D00596".
- Rosiglitazone legalUk "POM".
- Rosiglitazone legalUs "Rx-only".