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- Ristocetin abstract "Ristocetin is an antibiotic, obtained from Amycolatopsis lurida, previously used to treat staphylococcal infections. It is no longer used clinically because it caused thrombocytopenia and platelet agglutination. It is now used solely to assay those functions in vitro in the diagnosis of conditions such as von Willebrand disease (vWD) and Bernard-Soulier syndrome. Platelet agglutination caused by ristocetin can occur only in the presence of von Willebrand factor multimers, so if ristocetin is added to blood lacking the factor (or its receptor—see below), the platelets will not clump.In an unknown fashion, the antibiotic ristocetin causes von Willebrand factor to bind the platelet receptor glycoprotein Ib (GpIb), so when ristocetin is added to normal blood, it causes agglutination.In some types of vWD (types 2B and platelet-type), even very small amounts of ristocetin cause platelet aggregation when the patient's platelet-rich plasma is used. This paradox is explained by these types having gain-of-function mutations which cause the vWD high molecular-weight multimers to bind more tightly to their receptors on platelets (the alpha chains of glycoprotein Ib (GPIb) receptors). In the case of type 2B vWD, the gain-of-function mutation involves von Willebrand's factor (VWF gene), and in platelet-type vWD, the receptor is the object of the mutation (GPIb). This increased binding causes vWD because the high-molecular weight multimers are removed from circulation in plasma since they remain attached to the patient's platelets. Thus, if the patient's platelet-poor plasma is used, the ristocetin cofactor assay will not agglutinate standardized platelets (i.e., pooled platelets from normal donors that are fixed in formalin), similar to the other types of vWD.In all forms of the ristocetin assay, the platelets are fixed in formalin prior to the assay to prevent von Willebrand's factor stored in platelet granules from being released and participating in platelet aggregation. Thus, the ristocetin cofactor activity depends only upon high-molecular multimers of the factor present in circulating plasma.".
- Ristocetin thumbnail Ristocetin.png?width=300.
- Ristocetin wikiPageID "4323503".
- Ristocetin wikiPageLength "5615".
- Ristocetin wikiPageOutDegree "15".
- Ristocetin wikiPageRevisionID "668616487".
- Ristocetin wikiPageWikiLink Agglutination_(biology).
- Ristocetin wikiPageWikiLink Amycolatopsis.
- Ristocetin wikiPageWikiLink Bernard–Soulier_syndrome.
- Ristocetin wikiPageWikiLink Blood_plasma.
- Ristocetin wikiPageWikiLink Category:Antibiotics.
- Ristocetin wikiPageWikiLink Category:Chemical_pathology.
- Ristocetin wikiPageWikiLink Formaldehyde.
- Ristocetin wikiPageWikiLink Glycoprotein_Ib.
- Ristocetin wikiPageWikiLink Mutation.
- Ristocetin wikiPageWikiLink Platelet.
- Ristocetin wikiPageWikiLink Staphylococcal_infection.
- Ristocetin wikiPageWikiLink Thrombocytopenia.
- Ristocetin wikiPageWikiLink Von_Willebrand_disease.
- Ristocetin wikiPageWikiLink Von_Willebrand_factor.
- Ristocetin wikiPageWikiLinkText "Ristocetin".
- Ristocetin wikiPageWikiLinkText "ristocetin".
- Ristocetin imagefile "Ristocetin.png".
- Ristocetin imagesize "200".
- Ristocetin verifiedfields "changed".
- Ristocetin verifiedrevid "464382786".
- Ristocetin wikiPageUsesTemplate Template:Cascite.
- Ristocetin wikiPageUsesTemplate Template:Chembox.
- Ristocetin wikiPageUsesTemplate Template:Chembox_Hazards.
- Ristocetin wikiPageUsesTemplate Template:Chembox_Identifiers.
- Ristocetin wikiPageUsesTemplate Template:Chembox_Properties.
- Ristocetin wikiPageUsesTemplate Template:Chemspidercite.
- Ristocetin wikiPageUsesTemplate Template:Ebicite.
- Ristocetin wikiPageUsesTemplate Template:Fdacite.
- Ristocetin wikiPageUsesTemplate Template:Reflist.
- Ristocetin wikiPageUsesTemplate Template:See_also.
- Ristocetin wikiPageUsesTemplate Template:Stdinchicite.
- Ristocetin subject Category:Antibiotics.
- Ristocetin subject Category:Chemical_pathology.
- Ristocetin hypernym Antibiotic.
- Ristocetin type ChemicalCompound.
- Ristocetin type ChemicalSubstance.
- Ristocetin type Drug.
- Ristocetin type Chemical.
- Ristocetin type Product.
- Ristocetin type ChemicalObject.
- Ristocetin type Thing.
- Ristocetin type Q11173.
- Ristocetin comment "Ristocetin is an antibiotic, obtained from Amycolatopsis lurida, previously used to treat staphylococcal infections. It is no longer used clinically because it caused thrombocytopenia and platelet agglutination. It is now used solely to assay those functions in vitro in the diagnosis of conditions such as von Willebrand disease (vWD) and Bernard-Soulier syndrome.".
- Ristocetin label "Ristocetin".
- Ristocetin seeAlso Ristocetin-induced_platelet_aggregation.
- Ristocetin sameAs Q904599.
- Ristocetin sameAs Ristocetin.
- Ristocetin sameAs ریستوستین.
- Ristocetin sameAs Ristocétine.
- Ristocetin sameAs Ristocetina.
- Ristocetin sameAs Ristocetyna.
- Ristocetin sameAs m.0bx2xm.
- Ristocetin sameAs Ristocetin.
- Ristocetin sameAs Ristocetin.
- Ristocetin sameAs Q904599.
- Ristocetin wasDerivedFrom Ristocetin?oldid=668616487.
- Ristocetin depiction Ristocetin.png.
- Ristocetin isPrimaryTopicOf Ristocetin.