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- Richard_Wurtman abstract "Richard Wurtman, M.D., is the Cecil H. Green Distinguished Professor at the Massachusetts Institute of Technology and a Professor of Neuroscience in MIT’s Department of Brain & Cognitive Sciences, and of Neuropharmacology in the Harvard – MIT Division of Health Sciences & Technology.His research career encompasses three areas: Basic-science studies, principally on neurotransmitters and other brain chemicalsOne of the earliest areas of Wurtman's focus was in dietary precurors of neurotransmitters such as acetylcholine.Along with Nicholas Zervas of Beth Israel Hospital and Harvard Medical School, another early area of Wurtman's research pertained to the neurotransmitter dopamine, and its role in stroke physiology. Wurtman's studies occurred at a time of significant growth in research and understanding of neurotransmitters, with optimistic expectations for practical outcomes. Clinical studies to confirm that mechanisms discovered in the laboratory also operate in humans Translational work, usually in collaboration with foundations or companies, to apply the basic-science discoveries to finding new treatments for diseasesResearch performed in Wurtman's laboratory has generated about 1,000 research articles and 200 patents. One such patent was for a weight-loss drug, named Redux, which transpired to have some controversial side effects. Although at the time of its release, some optimism prevailed that it might herald a new approach, there remained some reservations amongst neurologists. Wurtman himself, while a proponent of the drug, stressed that \"it's not a magic pill\", and urged caution in its use. Wurtman also patented a pharmaceutical invention covering the use of melatonin for controlling sleep. Melatonin was itself subjected to \"starry-eyed extrapolations from experiments conducted on rats and mice\". While Wurtman noted that the use of small doses to induce sleep and shift the sleep cycle was uncontroversial, he criticised some of the extrapolations and claims being made about the benefits of melatonin supplements.Among discoveries from Wurtman's laboratory have been that Melatonin is a hormone, secreted at night-time, needed for the induction & maintenance of normal sleep Dietary carbohydrates, acting via insulin, increase brain tryptophan levels and consequently serotonin synthesis and release, thereby affecting appetite Serotoninergic synapses are thus a useful target for drugs to treat obesity and other conditions which affect appetite and mood (e.g. premenstrual syndrome; seasonal depression) Oral administration of neurotransmitter precursors such as choline, tyrosine or glutamine can enhance the synthesis and release of their products acetylcholine, dopamine or GABA (by increasing the substrate-saturation of the biosynthetic enzymes) Various neurotransmitters and \"second messengers\" can modulate the breakdown of APP (the amyloid-precursor protein) and thus the formation of amyloid beta, a protein important in the development of Alzheimer's disease. The biosynthesis in brain of synaptic membrane and its specializations (dendritic spines; neurites; synapses) can be enhanced by treatments affecting plasma composition.With wife Judith Wurtman, Wurtman co-edited an eight-volume series of books on “Nutrition and the Brain”, and with John Growdon, M.D. and Suzanne Corkin, Ph.D., a nine volume series on Alzheimer’s disease.Wurtman co-founded Interneuron Pharmaceuticals, a company aimed at marketing discoveries by M.I.T. scientists, and of Back Bay Scientific, Inc. He established the Center for Brain Sciences and Metabolism Charitable Trust, and serves as its Scientific Director.".
- Richard_Wurtman almaMater Harvard_Medical_School.
- Richard_Wurtman almaMater Massachusetts_General_Hospital.
- Richard_Wurtman almaMater National_Institutes_of_Health.
- Richard_Wurtman almaMater University_of_Pennsylvania.
- Richard_Wurtman birthDate "1936-03-09".
- Richard_Wurtman birthPlace Philadelphia.
- Richard_Wurtman birthPlace United_States.
- Richard_Wurtman birthYear "1936".
- Richard_Wurtman field Neuroscience.
- Richard_Wurtman residence United_States.
- Richard_Wurtman wikiPageExternalLink 1020.pdf.
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- Richard_Wurtman wikiPageExternalLink wurtmanlab.
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- Richard_Wurtman wikiPageWikiLink Acetylcholine.
- Richard_Wurtman wikiPageWikiLink Alzheimers_disease.
- Richard_Wurtman wikiPageWikiLink Amyloid_beta.
- Richard_Wurtman wikiPageWikiLink Annual_Review_of_Nutrition.
- Richard_Wurtman wikiPageWikiLink Beth_Israel_Deaconess_Medical_Center.
- Richard_Wurtman wikiPageWikiLink Biosynthesis.
- Richard_Wurtman wikiPageWikiLink Carbohydrate.
- Richard_Wurtman wikiPageWikiLink Category:1936_births.
- Richard_Wurtman wikiPageWikiLink Category:American_neuroscientists.
- Richard_Wurtman wikiPageWikiLink Category:American_pharmacologists.
- Richard_Wurtman wikiPageWikiLink Category:Harvard_Medical_School_alumni.
- Richard_Wurtman wikiPageWikiLink Category:Harvard_University_faculty.
- Richard_Wurtman wikiPageWikiLink Category:Living_people.
- Richard_Wurtman wikiPageWikiLink Category:Massachusetts_Institute_of_Technology_faculty.
- Richard_Wurtman wikiPageWikiLink Category:University_of_Pennsylvania_alumni.
- Richard_Wurtman wikiPageWikiLink Cecil_Howard_Green.
- Richard_Wurtman wikiPageWikiLink Choline.
- Richard_Wurtman wikiPageWikiLink Dexfenfluramine.
- Richard_Wurtman wikiPageWikiLink Dopamine.
- Richard_Wurtman wikiPageWikiLink Glutamine.
- Richard_Wurtman wikiPageWikiLink Harvard_Medical_School.
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- Richard_Wurtman wikiPageWikiLink Hormone.
- Richard_Wurtman wikiPageWikiLink Insulin.
- Richard_Wurtman wikiPageWikiLink Massachusetts_General_Hospital.
- Richard_Wurtman wikiPageWikiLink Massachusetts_Institute_of_Technology.
- Richard_Wurtman wikiPageWikiLink Melatonin.
- Richard_Wurtman wikiPageWikiLink National_Institutes_of_Health.
- Richard_Wurtman wikiPageWikiLink Neuropharmacology.
- Richard_Wurtman wikiPageWikiLink Neuroscience.
- Richard_Wurtman wikiPageWikiLink Neurotransmitter.
- Richard_Wurtman wikiPageWikiLink Obesity.
- Richard_Wurtman wikiPageWikiLink Pharmacological_Reviews.
- Richard_Wurtman wikiPageWikiLink Philadelphia.
- Richard_Wurtman wikiPageWikiLink Premenstrual_syndrome.
- Richard_Wurtman wikiPageWikiLink Scientific_American.
- Richard_Wurtman wikiPageWikiLink Serotonin.
- Richard_Wurtman wikiPageWikiLink Springer_Science+Business_Media.
- Richard_Wurtman wikiPageWikiLink Stroke.
- Richard_Wurtman wikiPageWikiLink The_American_Journal_of_Clinical_Nutrition.
- Richard_Wurtman wikiPageWikiLink The_Journal_of_Clinical_Endocrinology_and_Metabolism.
- Richard_Wurtman wikiPageWikiLink Tryptophan.
- Richard_Wurtman wikiPageWikiLink Tyrosine.
- Richard_Wurtman wikiPageWikiLink United_States.
- Richard_Wurtman wikiPageWikiLink University_of_Pennsylvania.
- Richard_Wurtman wikiPageWikiLink UpToDate.
- Richard_Wurtman wikiPageWikiLinkText "Richard Wurtman".
- Richard_Wurtman almaMater "A.B., University of Pennsylvania".
- Richard_Wurtman almaMater "Clinical Training in Medicine and in Endocrinology, Massachusetts General Hospital".
- Richard_Wurtman almaMater "M.D., Harvard Medical School".
- Richard_Wurtman almaMater "Research Training, National Institutes of Health".
- Richard_Wurtman birthDate "1936-03-09".
- Richard_Wurtman birthPlace Philadelphia.
- Richard_Wurtman birthPlace United_States.
- Richard_Wurtman dateOfBirth "1936-03-09".
- Richard_Wurtman fields "Neuroscience, Treatments for Brain Diseases, Nutrition and the Brain".
- Richard_Wurtman knownFor "Invention of use of melatonin to promote sleep".
- Richard_Wurtman knownFor "Strategies for finding drugs to treat Alzheimer's Disease;".
- Richard_Wurtman knownFor "Use of serotoninergic drugs to treat obesity and other disorders characterized by disturbances in both appetite and mood".
- Richard_Wurtman knownFor "Use of their circulating precursors to increase the syntheses of brain neurotransmitters and membranes".
- Richard_Wurtman name "Richard Wurtman".
- Richard_Wurtman name "Wurtman, Richard".
- Richard_Wurtman placeOfBirth Philadelphia.
- Richard_Wurtman placeOfBirth United_States.
- Richard_Wurtman residence United_States.
- Richard_Wurtman shortDescription "Professor, researcher".
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- Richard_Wurtman workplaces Harvard_University.
- Richard_Wurtman workplaces Massachusetts_Institute_of_Technology.