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- Ribozyme abstract "Ribozymes (ribonucleic acid enzymes) are RNA molecules that are capable of catalyzing specific biochemical reactions, similar to the action of protein enzymes. The 1982 discovery of ribozymes demonstrated that RNA can be both genetic material (like DNA) and a biological catalyst (like protein enzymes), and contributed to the RNA world hypothesis, which suggests that RNA may have been important in the evolution of prebiotic self-replicating systems. The most common activities of natural or in vitro-evolved ribozymes are the cleavage or ligation of RNA and DNA and peptide bond formation. Within the ribosome, ribozymes function as part of the large subunit ribosomal RNA to link amino acids during protein synthesis. They also participate in a variety of RNA processing reactions, including RNA splicing, viral replication, and transfer RNA biosynthesis. Examples of ribozymes include the hammerhead ribozyme, the VS ribozyme, Leadzyme and the hairpin ribozyme.Investigators studying the origin of life have produced ribozymes in the laboratory that are capable of catalyzing their own synthesis under very specific conditions, such as an RNA polymerase ribozyme. Mutagenesis and selection has been performed resulting in isolation of improved variants of the \"Round-18\" polymerase ribozyme from 2001. \"B6.61\" is able to add up to 20 nucleotides to a primer template in 24 hours, until it decomposes by cleavage of its phosphodiester bonds. The \"tC19Z\" ribozyme can add up to 95 nucleotides with a fidelity of 0.0083 mutations/nucleotide.Attempts have been made to develop ribozymes as therapeutic agents, as enzymes which target defined RNA sequences for cleavage, as biosensors, and for applications in functional genomics and gene discovery.".
- Ribozyme thumbnail Full_length_hammerhead_ribozyme.png?width=300.
- Ribozyme wikiPageExternalLink tom-cech-discovering-ribozymes.html.
- Ribozyme wikiPageID "237132".
- Ribozyme wikiPageLength "23841".
- Ribozyme wikiPageOutDegree "126".
- Ribozyme wikiPageRevisionID "706777395".
- Ribozyme wikiPageWikiLink Abiogenesis.
- Ribozyme wikiPageWikiLink Amino_acid.
- Ribozyme wikiPageWikiLink Autocatalysis.
- Ribozyme wikiPageWikiLink Biology.
- Ribozyme wikiPageWikiLink Biomolecular_structure.
- Ribozyme wikiPageWikiLink Biosensor.
- Ribozyme wikiPageWikiLink Biotin.
- Ribozyme wikiPageWikiLink Carl_Woese.
- Ribozyme wikiPageWikiLink Catalysis.
- Ribozyme wikiPageWikiLink Category:Biomolecules.
- Ribozyme wikiPageWikiLink Category:Catalysts.
- Ribozyme wikiPageWikiLink Category:Chemical_kinetics.
- Ribozyme wikiPageWikiLink Category:Enzymes.
- Ribozyme wikiPageWikiLink Category:Metabolism.
- Ribozyme wikiPageWikiLink Category:RNA.
- Ribozyme wikiPageWikiLink Category:RNA_splicing.
- Ribozyme wikiPageWikiLink Category:Ribozymes.
- Ribozyme wikiPageWikiLink Cell_(biology).
- Ribozyme wikiPageWikiLink Cell_(journal).
- Ribozyme wikiPageWikiLink Chaperone_(protein).
- Ribozyme wikiPageWikiLink Chemistry.
- Ribozyme wikiPageWikiLink Cilium.
- Ribozyme wikiPageWikiLink Cofactor_(biochemistry).
- Ribozyme wikiPageWikiLink Complementary_DNA.
- Ribozyme wikiPageWikiLink Concatemer.
- Ribozyme wikiPageWikiLink Conformational_isomerism.
- Ribozyme wikiPageWikiLink Covalent_bond.
- Ribozyme wikiPageWikiLink DNA.
- Ribozyme wikiPageWikiLink Deoxyribozyme.
- Ribozyme wikiPageWikiLink Divalent.
- Ribozyme wikiPageWikiLink Enzyme.
- Ribozyme wikiPageWikiLink Error-prone_PCR.
- Ribozyme wikiPageWikiLink Francis_Crick.
- Ribozyme wikiPageWikiLink Functional_genomics.
- Ribozyme wikiPageWikiLink GIR1_branching_ribozyme.
- Ribozyme wikiPageWikiLink GlmS_glucosamine-6-phosphate_activated_ribozyme.
- Ribozyme wikiPageWikiLink Group_II_intron.
- Ribozyme wikiPageWikiLink Group_I_catalytic_intron.
- Ribozyme wikiPageWikiLink HIV.
- Ribozyme wikiPageWikiLink Hairpin_ribozyme.
- Ribozyme wikiPageWikiLink Hammerhead_ribozyme.
- Ribozyme wikiPageWikiLink Hepatitis_delta_virus_ribozyme.
- Ribozyme wikiPageWikiLink In_vitro.
- Ribozyme wikiPageWikiLink Intron.
- Ribozyme wikiPageWikiLink Ion.
- Ribozyme wikiPageWikiLink Laboratory.
- Ribozyme wikiPageWikiLink Leadzyme.
- Ribozyme wikiPageWikiLink Leslie_Orgel.
- Ribozyme wikiPageWikiLink Ligand.
- Ribozyme wikiPageWikiLink Ligase.
- Ribozyme wikiPageWikiLink Ligase_ribozyme.
- Ribozyme wikiPageWikiLink Living_fossil.
- Ribozyme wikiPageWikiLink Magnesium.
- Ribozyme wikiPageWikiLink Molecular_machine.
- Ribozyme wikiPageWikiLink Mutagenesis.
- Ribozyme wikiPageWikiLink Nobel_Prize.
- Ribozyme wikiPageWikiLink Northwestern_University.
- Ribozyme wikiPageWikiLink Nucleic_acid_analogue.
- Ribozyme wikiPageWikiLink Nucleic_acid_tertiary_structure.
- Ribozyme wikiPageWikiLink Nucleotide.
- Ribozyme wikiPageWikiLink OLE_RNA.
- Ribozyme wikiPageWikiLink PAH_world_hypothesis.
- Ribozyme wikiPageWikiLink Peptide_nucleic_acid.
- Ribozyme wikiPageWikiLink Phenylalanine.
- Ribozyme wikiPageWikiLink Phosphodiester_bond.
- Ribozyme wikiPageWikiLink Polymerase.
- Ribozyme wikiPageWikiLink Post-transcriptional_modification.
- Ribozyme wikiPageWikiLink Prion.
- Ribozyme wikiPageWikiLink Protein.
- Ribozyme wikiPageWikiLink Protein_folding.
- Ribozyme wikiPageWikiLink Protozoa.
- Ribozyme wikiPageWikiLink RNA.
- Ribozyme wikiPageWikiLink RNA_polymerase.
- Ribozyme wikiPageWikiLink RNA_splicing.
- Ribozyme wikiPageWikiLink RNA_world.
- Ribozyme wikiPageWikiLink Reverse_transcriptase.
- Ribozyme wikiPageWikiLink Ribonuclease_P.
- Ribozyme wikiPageWikiLink Ribosomal_RNA.
- Ribozyme wikiPageWikiLink Ribosomal_binding_site.
- Ribozyme wikiPageWikiLink Ribosome.
- Ribozyme wikiPageWikiLink Ribosome-T.
- Ribozyme wikiPageWikiLink Riboswitch.
- Ribozyme wikiPageWikiLink Sidney_Altman.
- Ribozyme wikiPageWikiLink Spiegelmans_Monster.
- Ribozyme wikiPageWikiLink Spliceosome.
- Ribozyme wikiPageWikiLink Streptavidin.
- Ribozyme wikiPageWikiLink Systematic_evolution_of_ligands_by_exponential_enrichment.
- Ribozyme wikiPageWikiLink Tetrahymena.
- Ribozyme wikiPageWikiLink Theophylline.
- Ribozyme wikiPageWikiLink Thomas_Cech.
- Ribozyme wikiPageWikiLink Transfer_RNA.
- Ribozyme wikiPageWikiLink Translation_(biology).
- Ribozyme wikiPageWikiLink Twister_ribozyme.