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- Reverse_pharmacology abstract "In the field of drug discovery, reverse pharmacology also known as target-based drug discovery (TDD), a hypothesis is first made that modulation of the activity of a specific protein target will have beneficial therapeutic effects. Screening of chemical libraries of small molecules is then used to identify compounds that bind with high affinity to the target. The hits from these screens are then used as starting points for drug discovery. This method became popular after the sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins. This method is the most widely used in drug discovery today. Differently than the classical (forward) pharmacology, with the reverse pharmacology approach in vivo efficacy of identified active (lead) compounds is usually performed in the final drug discovery stages.".
- Reverse_pharmacology thumbnail Forward_and_reverse_pharmacology.jpg?width=300.
- Reverse_pharmacology wikiPageID "35290643".
- Reverse_pharmacology wikiPageLength "3190".
- Reverse_pharmacology wikiPageOutDegree "13".
- Reverse_pharmacology wikiPageRevisionID "705448736".
- Reverse_pharmacology wikiPageWikiLink Biological_target.
- Reverse_pharmacology wikiPageWikiLink Category:Drug_discovery.
- Reverse_pharmacology wikiPageWikiLink Chemical_library.
- Reverse_pharmacology wikiPageWikiLink Classical_pharmacology.
- Reverse_pharmacology wikiPageWikiLink Drug_discovery.
- Reverse_pharmacology wikiPageWikiLink File:Forward_and_reverse_pharmacology.jpg.
- Reverse_pharmacology wikiPageWikiLink High-throughput_screening.
- Reverse_pharmacology wikiPageWikiLink Human_Genome_Project.
- Reverse_pharmacology wikiPageWikiLink Human_genome.
- Reverse_pharmacology wikiPageWikiLink Lead_compound.
- Reverse_pharmacology wikiPageWikiLink Small_molecule.
- Reverse_pharmacology wikiPageWikiLinkText "Reverse pharmacology".
- Reverse_pharmacology wikiPageWikiLinkText "reverse pharmacology".
- Reverse_pharmacology wikiPageUsesTemplate Template:About.
- Reverse_pharmacology wikiPageUsesTemplate Template:Clear.
- Reverse_pharmacology wikiPageUsesTemplate Template:Pharma-stub.
- Reverse_pharmacology wikiPageUsesTemplate Template:Pharmacology.
- Reverse_pharmacology wikiPageUsesTemplate Template:Reflist.
- Reverse_pharmacology subject Category:Drug_discovery.
- Reverse_pharmacology type Science.
- Reverse_pharmacology comment "In the field of drug discovery, reverse pharmacology also known as target-based drug discovery (TDD), a hypothesis is first made that modulation of the activity of a specific protein target will have beneficial therapeutic effects. Screening of chemical libraries of small molecules is then used to identify compounds that bind with high affinity to the target. The hits from these screens are then used as starting points for drug discovery.".
- Reverse_pharmacology label "Reverse pharmacology".
- Reverse_pharmacology sameAs Q7318256.
- Reverse_pharmacology sameAs m.0j7jpwz.
- Reverse_pharmacology sameAs Q7318256.
- Reverse_pharmacology wasDerivedFrom Reverse_pharmacology?oldid=705448736.
- Reverse_pharmacology depiction Forward_and_reverse_pharmacology.jpg.
- Reverse_pharmacology isPrimaryTopicOf Reverse_pharmacology.