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- Release_factor abstract "A release factor is a protein that allows for the termination of translation by recognizing the termination codon or stop codon in an mRNA sequence. During translation of mRNA, most codons are recognized by \"charged\" tRNA molecules, called aminoacyl-tRNAs because they are adhered to specific amino acids corresponding to each tRNA's anticodon.In the standard genetic code, there are three mRNA stop codons: UAG (\"amber\"), UAA (\"ochre\"), and UGA (\"opal\" or \"umber\").Although these stop codons are triplets just like ordinary codons, they are not decoded by tRNAs. It was discovered by Mario Capecchi in 1967 that, instead, tRNAs do not ordinarily recognize stop codons at all, and that what he named \"release factor\" was not a tRNA molecule but a protein. Later, it was demonstrated that different release factors recognize different stop codons.Prokaryotic translation termination is mediated by three prokaryotic release factors: RF1, RF2, and RF3.RF1 recognizes the termination codons UAA and UAGRF2 recognizes UAA and UGARF3 is a GTP-binding protein that leads to the dissociation of RF1/RF2 after peptide releaseLikewise, eukaryotic translation termination involves two eukaryotic release factors: eRF1 and eRF3.eRF1 recognizes all three termination codonseRF3 is a ribosome-dependent GTPase that helps eRF1 release the completed polypeptide↑ ↑ ↑ 3.0 3.1".
- Release_factor wikiPageID "6093623".
- Release_factor wikiPageLength "2210".
- Release_factor wikiPageOutDegree "16".
- Release_factor wikiPageRevisionID "702169783".
- Release_factor wikiPageWikiLink Amino_acid.
- Release_factor wikiPageWikiLink Aminoacyl-tRNA.
- Release_factor wikiPageWikiLink Category:Proteins.
- Release_factor wikiPageWikiLink Eukaryotic_release_factors.
- Release_factor wikiPageWikiLink Genetic_code.
- Release_factor wikiPageWikiLink Mario_Capecchi.
- Release_factor wikiPageWikiLink Messenger_RNA.
- Release_factor wikiPageWikiLink Prokaryotic_release_factors.
- Release_factor wikiPageWikiLink Protein.
- Release_factor wikiPageWikiLink Releasing_and_inhibiting_hormones.
- Release_factor wikiPageWikiLink Stop_codon.
- Release_factor wikiPageWikiLink Transfer_RNA.
- Release_factor wikiPageWikiLink Translation_(biology).
- Release_factor wikiPageWikiLinkText "Release factor".
- Release_factor wikiPageWikiLinkText "release factor".
- Release_factor wikiPageWikiLinkText "releasing factor".
- Release_factor wikiPageUsesTemplate Template:GeneticTranslation.
- Release_factor wikiPageUsesTemplate Template:Hatnote.
- Release_factor wikiPageUsesTemplate Template:MeshName.
- Release_factor wikiPageUsesTemplate Template:Protein-stub.
- Release_factor subject Category:Proteins.
- Release_factor hypernym Protein.
- Release_factor type Biomolecule.
- Release_factor type Protein.
- Release_factor type Biomolecule.
- Release_factor type Nutrient.
- Release_factor comment "A release factor is a protein that allows for the termination of translation by recognizing the termination codon or stop codon in an mRNA sequence.".
- Release_factor label "Release factor".
- Release_factor sameAs Q1994527.
- Release_factor sameAs Czynnik_uwalniający.
- Release_factor sameAs m.0fpt9v.
- Release_factor sameAs Факторы_терминации_трансляции.
- Release_factor sameAs Фактори_термінації_трансляції.
- Release_factor sameAs Q1994527.
- Release_factor sameAs 释放因子.
- Release_factor wasDerivedFrom Release_factor?oldid=702169783.
- Release_factor isPrimaryTopicOf Release_factor.