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- Recombination_signal_sequences abstract "The regional genes (V, D, J), used to generate T-cell receptors and Immunoglobulin molecules, are flanked by recombination signal sequences (RSSs) that are recognized by a group of enzymes known collectively as the VDJ recombinase. RSSs are composed of seven conserved nucleotides (a heptamer) that reside next to the gene encoding sequence followed by a spacer (containing either 12 or 23 unconserved nucleotides) followed by a conserved nonamer (9 base pairs). The RSSs are present on the 3’ side (downstream) of a V region and the 5’ side (upstream) of the J region. These are the sides that will be involved in the joining. Only a pair of dissimilar spacer RSSs are efficiently recombined (i.e. one with a spacer of 12 nucleotides will be recombined with one that has a spacer containing 23 nucleotides). This is known as the 12/23 rule of recombination (or the one-turn/two-turn rule).".
- Recombination_signal_sequences wikiPageID "19853121".
- Recombination_signal_sequences wikiPageLength "1162".
- Recombination_signal_sequences wikiPageOutDegree "7".
- Recombination_signal_sequences wikiPageRevisionID "520975709".
- Recombination_signal_sequences wikiPageWikiLink Antibody.
- Recombination_signal_sequences wikiPageWikiLink Category:Immune_system.
- Recombination_signal_sequences wikiPageWikiLink Directionality_(molecular_biology).
- Recombination_signal_sequences wikiPageWikiLink Genetic_recombination.
- Recombination_signal_sequences wikiPageWikiLink T_cell_receptor.
- Recombination_signal_sequences wikiPageWikiLink V(D)J_recombination.
- Recombination_signal_sequences wikiPageWikiLinkText "Recombination signal sequences".
- Recombination_signal_sequences wikiPageWikiLinkText "recombination signal sequences".
- Recombination_signal_sequences wikiPageUsesTemplate Template:Immunology-stub.
- Recombination_signal_sequences wikiPageUsesTemplate Template:Unreferenced.
- Recombination_signal_sequences subject Category:Immune_system.
- Recombination_signal_sequences type Redirect.
- Recombination_signal_sequences comment "The regional genes (V, D, J), used to generate T-cell receptors and Immunoglobulin molecules, are flanked by recombination signal sequences (RSSs) that are recognized by a group of enzymes known collectively as the VDJ recombinase. RSSs are composed of seven conserved nucleotides (a heptamer) that reside next to the gene encoding sequence followed by a spacer (containing either 12 or 23 unconserved nucleotides) followed by a conserved nonamer (9 base pairs).".
- Recombination_signal_sequences label "Recombination signal sequences".
- Recombination_signal_sequences sameAs Q7302710.
- Recombination_signal_sequences sameAs m.04q7t_q.
- Recombination_signal_sequences sameAs Q7302710.
- Recombination_signal_sequences wasDerivedFrom Recombination_signal_sequences?oldid=520975709.
- Recombination_signal_sequences isPrimaryTopicOf Recombination_signal_sequences.