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- RasGEF_domain abstract "RasGEF domain is domain found in the CDC25 family of guanine nucleotide exchange factors for Ras-like small GTPases.Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP. The latter proteins are known as guanine-nucleotide dissociation stimulators (GDSs) (or also as guanine-nucleotide releasing (or exchange) factors (GRFs)). Proteins that act as GDS can be classified into at least two families, on the basis of sequence similarities, the CDC24 family (see IPR001331) and this CDC25 (RasGEF) family.The size of the proteins of the CDC25 family range from 309 residues (LTE1) to 1596 residues (sos). The sequence similarity shared by all these proteins is limited to a region of about 250 amino acids generally located in their C-terminal section (currently the only exceptions are sos and ralGDS where this domain makes up the central part of the protein). This domain has been shown, in CDC25 an SCD25, to be essential for the activity of these proteins.".
- RasGEF_domain symbol "RasGEF".
- RasGEF_domain thumbnail PDB_1bkd_EBI.jpg?width=300.
- RasGEF_domain wikiPageID "14682858".
- RasGEF_domain wikiPageLength "4901".
- RasGEF_domain wikiPageOutDegree "34".
- RasGEF_domain wikiPageRevisionID "708059135".
- RasGEF_domain wikiPageWikiLink Category:Peripheral_membrane_proteins.
- RasGEF_domain wikiPageWikiLink Category:Protein_domains.
- RasGEF_domain wikiPageWikiLink Category:Protein_families.
- RasGEF_domain wikiPageWikiLink GTPase.
- RasGEF_domain wikiPageWikiLink Guanine_nucleotide_exchange_factor.
- RasGEF_domain wikiPageWikiLink KNDC1.
- RasGEF_domain wikiPageWikiLink PLCE1.
- RasGEF_domain wikiPageWikiLink Protein_family.
- RasGEF_domain wikiPageWikiLink RALGDS.
- RasGEF_domain wikiPageWikiLink RALGPS1.
- RasGEF_domain wikiPageWikiLink RALGPS2.
- RasGEF_domain wikiPageWikiLink RAPGEF1.
- RasGEF_domain wikiPageWikiLink RAPGEF2.
- RasGEF_domain wikiPageWikiLink RAPGEF3.
- RasGEF_domain wikiPageWikiLink RAPGEF4.
- RasGEF_domain wikiPageWikiLink RAPGEF5.
- RasGEF_domain wikiPageWikiLink RAPGEF6.
- RasGEF_domain wikiPageWikiLink RAPGEFL1.
- RasGEF_domain wikiPageWikiLink RASGEF1A.
- RasGEF_domain wikiPageWikiLink RASGEF1B.
- RasGEF_domain wikiPageWikiLink RASGEF1C.
- RasGEF_domain wikiPageWikiLink RASGRF1.
- RasGEF_domain wikiPageWikiLink RASGRF2.
- RasGEF_domain wikiPageWikiLink RASGRP1.
- RasGEF_domain wikiPageWikiLink RASGRP2.
- RasGEF_domain wikiPageWikiLink RASGRP3.
- RasGEF_domain wikiPageWikiLink RASGRP4.
- RasGEF_domain wikiPageWikiLink RGL1.
- RasGEF_domain wikiPageWikiLink RGL2.
- RasGEF_domain wikiPageWikiLink RGL3.
- RasGEF_domain wikiPageWikiLink Ras_superfamily.
- RasGEF_domain wikiPageWikiLink Rhamnogalacturonan_endolyase.
- RasGEF_domain wikiPageWikiLink SOS1.
- RasGEF_domain wikiPageWikiLink Son_of_Sevenless.
- RasGEF_domain wikiPageWikiLinkText "RasGEF domain".
- RasGEF_domain caption "Structure of human H-Ras.".
- RasGEF_domain cdd "cd00155".
- RasGEF_domain interpro "IPR001895".
- RasGEF_domain name "RasGEF domain".
- RasGEF_domain opmProtein "1".
- RasGEF_domain pdb "C:777-963 S:777-963 B:777-963 S:777-963 A:777-963 S:777-963 S:777-963 S:777-963".
- RasGEF_domain pfam "PF00617".
- RasGEF_domain prosite "PDOC00594".
- RasGEF_domain scop "1".
- RasGEF_domain smart "RasGEF".
- RasGEF_domain symbol "RasGEF".
- RasGEF_domain wikiPageUsesTemplate Template:Cite_journal.
- RasGEF_domain wikiPageUsesTemplate Template:InterPro.
- RasGEF_domain wikiPageUsesTemplate Template:InterPro_content.
- RasGEF_domain wikiPageUsesTemplate Template:Main.
- RasGEF_domain wikiPageUsesTemplate Template:Membrane-protein-stub.
- RasGEF_domain wikiPageUsesTemplate Template:PDB3.
- RasGEF_domain wikiPageUsesTemplate Template:Pfam_box.
- RasGEF_domain wikiPageUsesTemplate Template:Reflist.
- RasGEF_domain subject Category:Peripheral_membrane_proteins.
- RasGEF_domain subject Category:Protein_domains.
- RasGEF_domain subject Category:Protein_families.
- RasGEF_domain hypernym Domain.
- RasGEF_domain type Biomolecule.
- RasGEF_domain type Protein.
- RasGEF_domain type Chemical.
- RasGEF_domain type Domain.
- RasGEF_domain type Thing.
- RasGEF_domain type Q206229.
- RasGEF_domain type Q8054.
- RasGEF_domain comment "RasGEF domain is domain found in the CDC25 family of guanine nucleotide exchange factors for Ras-like small GTPases.Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP.".
- RasGEF_domain label "RasGEF domain".
- RasGEF_domain sameAs Q7294624.
- RasGEF_domain sameAs m.03gs_g_.
- RasGEF_domain sameAs Q7294624.
- RasGEF_domain wasDerivedFrom RasGEF_domain?oldid=708059135.
- RasGEF_domain depiction PDB_1bkd_EBI.jpg.
- RasGEF_domain isPrimaryTopicOf RasGEF_domain.