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- Radiation-induced_cognitive_decline abstract "Radiation-induced cognitive decline describes the possible correlation between radiation therapy and mild cognitive impairment. Radiation therapy is used mainly in the treatment of cancer. Radiation therapy can be used to cure care or shrink tumors that are interfering with quality of life. Sometimes radiation therapy is used alone; other times it is used in conjunction with chemotherapy and surgery. For people with brain tumors, radiation can be an effective treatment because chemotherapy is often less effective due to the blood–brain barrier. Unfortunately for some patients, as time passes, people who received radiation therapy may begin experiencing deficits in their learning, memory, and spatial information processing abilities. The learning, memory, and spatial information processing abilities are dependent on proper hippocampus functionality. Therefore, any hippocampus dysfunction will result in deficits in learning, memory, and spatial information processing ability. The hippocampus is one of two structures of the central nervous system where neurogenesis continues after birth. The other structure that undergoes neurogenesis is the olfactory bulb. Therefore, it has been proposed that neurogenesis plays some role in the proper functionality of the hippocampus and the olfactory bulb. To test this proposal, a group of rats with normal hippocampal neurogenesis (control) were subjected to a placement recognition exercise that required proper hippocampus function to complete. Afterwards a second group of rats (experimental) were subjected to the same exercise but in that trial their neurogenesis in the hippocampus was arrested. It was found that the experimental group was not able to distinguish between its familiar and unexplored territory. The experimental group spent more time exploring the familiar territory, while the control group spent more time exploring the new territory. The results indicate that neurogenesis in the hippocampus is important for memory and proper hippocampal functionality. Therefore if radiation therapy inhibits neurogenesis in the hippocampus it would lead to the cognitive decline observed in patients who have received this radiation therapy.In animal studies discussed by Monje and Palmer in \"Radiation Injury and Neurogenesis\", it has been proven that radiation does indeed decrease or arrest neurogenesis altogether in the hippocampus. This decrease in neurogenesis is due to apoptosis of the neurons which usually occurs after irradiation. However it has not been proven whether the apoptosis is a direct result of the radiation itself or if there are other factors that cause neuronal apoptosis, namely changes in the hippocampus micro-environment or damage to the precursor pool. Determining the exact cause of the cell apoptosis is important because then it maybe possible to inhibit the apoptosis and reverse the effects of the arrested neurogenesis.".
- Radiation-induced_cognitive_decline wikiPageID "14470857".
- Radiation-induced_cognitive_decline wikiPageLength "24286".
- Radiation-induced_cognitive_decline wikiPageOutDegree "25".
- Radiation-induced_cognitive_decline wikiPageRevisionID "648332079".
- Radiation-induced_cognitive_decline wikiPageWikiLink Apoptosis.
- Radiation-induced_cognitive_decline wikiPageWikiLink Category:Radiation_health_effects.
- Radiation-induced_cognitive_decline wikiPageWikiLink Central_nervous_system.
- Radiation-induced_cognitive_decline wikiPageWikiLink Chemotherapy.
- Radiation-induced_cognitive_decline wikiPageWikiLink Cytokine.
- Radiation-induced_cognitive_decline wikiPageWikiLink Electrochemotherapy.
- Radiation-induced_cognitive_decline wikiPageWikiLink Electroconvulsive_therapy.
- Radiation-induced_cognitive_decline wikiPageWikiLink Environmental_enrichment_(neural).
- Radiation-induced_cognitive_decline wikiPageWikiLink Equivalent_dose.
- Radiation-induced_cognitive_decline wikiPageWikiLink Hippocampus.
- Radiation-induced_cognitive_decline wikiPageWikiLink Ionizing_radiation.
- Radiation-induced_cognitive_decline wikiPageWikiLink Lipopolysaccharide.
- Radiation-induced_cognitive_decline wikiPageWikiLink Mild_cognitive_impairment.
- Radiation-induced_cognitive_decline wikiPageWikiLink Neurogenesis.
- Radiation-induced_cognitive_decline wikiPageWikiLink Neuroglia.
- Radiation-induced_cognitive_decline wikiPageWikiLink Olfactory_bulb.
- Radiation-induced_cognitive_decline wikiPageWikiLink Post-chemotherapy_cognitive_impairment.
- Radiation-induced_cognitive_decline wikiPageWikiLink Precursor_cell.
- Radiation-induced_cognitive_decline wikiPageWikiLink Radiation_helmet.
- Radiation-induced_cognitive_decline wikiPageWikiLink Radiation_therapy.
- Radiation-induced_cognitive_decline wikiPageWikiLink Targeted_therapy.
- Radiation-induced_cognitive_decline wikiPageWikiLinkText "Radiation-induced cognitive decline".
- Radiation-induced_cognitive_decline wikiPageWikiLinkText "cognitive decline".
- Radiation-induced_cognitive_decline wikiPageUsesTemplate Template:Citation_needed.
- Radiation-induced_cognitive_decline wikiPageUsesTemplate Template:Radiation_poisoning.
- Radiation-induced_cognitive_decline wikiPageUsesTemplate Template:Reflist.
- Radiation-induced_cognitive_decline subject Category:Radiation_health_effects.
- Radiation-induced_cognitive_decline type Determinant.
- Radiation-induced_cognitive_decline type Effect.
- Radiation-induced_cognitive_decline type Physic.
- Radiation-induced_cognitive_decline type Redirect.
- Radiation-induced_cognitive_decline comment "Radiation-induced cognitive decline describes the possible correlation between radiation therapy and mild cognitive impairment. Radiation therapy is used mainly in the treatment of cancer. Radiation therapy can be used to cure care or shrink tumors that are interfering with quality of life. Sometimes radiation therapy is used alone; other times it is used in conjunction with chemotherapy and surgery.".
- Radiation-induced_cognitive_decline label "Radiation-induced cognitive decline".
- Radiation-induced_cognitive_decline sameAs Q7280328.
- Radiation-induced_cognitive_decline sameAs m.03d4lwl.
- Radiation-induced_cognitive_decline sameAs Q7280328.
- Radiation-induced_cognitive_decline wasDerivedFrom Radiation-induced_cognitive_decline?oldid=648332079.
- Radiation-induced_cognitive_decline isPrimaryTopicOf Radiation-induced_cognitive_decline.