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- Rab_GDP_dissociation_inhibitors abstract "In molecular biology, the Rab GDP dissociation inhibitors (Rab GDIs) constitute a family of small GTPases that serve a regulatory role in vesicular membrane traffic. C-terminal geranylgeranylation is crucial for their membrane association and function. This post-translational modification is catalysed by Rab geranylgeranyl transferase (Rab-GGTase), a multi-subunit enzyme that contains a catalytic heterodimer and an accessory component, termed Rab escort protein (REP)-1. REP-1 presents newly synthesised Rab proteins to the catalytic component, and forms a stable complex with the prenylated proteins following the transfer reaction. The mechanism of REP-1-mediated membrane association of Rab5 is similar to that mediated by Rab GDP dissociation inhibitor (GDI). REP-1 and Rab GDI also share other functional properties, including the ability to inhibit the release of GDP and to remove Rab proteins from membranes.The crystal structure of the bovine alpha-isoform of Rab GDI has been determined to a resolution of 1.81 Angstrom. The protein is composed of two main structural units: a large complex multi-sheet domain I, and a smaller alpha-helical domain II.The structural organisation of domain I is closely related to FAD-containing monooxygenases and oxidases. Conserved regions common to GDI and the choroideraemia gene product, which delivers Rab to catalytic subunits of Rab geranylgeranyltransferase II, are clustered on one face of the domain. The two most conserved regions form a compact structure at the apex of the molecule; site-directed mutagenesis has shown these regions to play a critical role in the binding of Rab proteins.".
- Rab_GDP_dissociation_inhibitors symbol "GDI".
- Rab_GDP_dissociation_inhibitors thumbnail PDB_2bcg_EBI.jpg?width=300.
- Rab_GDP_dissociation_inhibitors wikiPageID "32955527".
- Rab_GDP_dissociation_inhibitors wikiPageLength "3614".
- Rab_GDP_dissociation_inhibitors wikiPageOutDegree "32".
- Rab_GDP_dissociation_inhibitors wikiPageRevisionID "592889975".
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Alpha_helix.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Biomolecular_structure.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink C-terminus.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Catalysis.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Category:Protein_families.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Cattle.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Conserved_sequence.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Crystal_structure.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Enzyme.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Flavin_adenine_dinucleotide.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink GTPase.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Gene.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Geranylgeranylation.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Geranylgeranyltransferase_type_1.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Membrane.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Oxidase.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Post-translational_modification.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Prenylation.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Protein.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Protein_dimer.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Protein_domain.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Protein_family.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Protein_isoform.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Protein_subunit.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Rab_escort_protein.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Site-directed_mutagenesis.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Vesicle_(biology_and_chemistry).
- Rab_GDP_dissociation_inhibitors wikiPageWikiLink Ångström.
- Rab_GDP_dissociation_inhibitors wikiPageWikiLinkText "GDP dissociation inhibitor".
- Rab_GDP_dissociation_inhibitors caption "structure of doubly prenylated ypt1:gdi complex".
- Rab_GDP_dissociation_inhibitors interpro "IPR018203".
- Rab_GDP_dissociation_inhibitors name "GDP dissociation inhibitor".
- Rab_GDP_dissociation_inhibitors pfam "PF00996".
- Rab_GDP_dissociation_inhibitors pfamClan "CL0063".
- Rab_GDP_dissociation_inhibitors scop "1".
- Rab_GDP_dissociation_inhibitors symbol "GDI".
- Rab_GDP_dissociation_inhibitors wikiPageUsesTemplate Template:Infobox_protein_family.
- Rab_GDP_dissociation_inhibitors wikiPageUsesTemplate Template:InterPro_content.
- Rab_GDP_dissociation_inhibitors wikiPageUsesTemplate Template:Orphan.
- Rab_GDP_dissociation_inhibitors wikiPageUsesTemplate Template:Reflist.
- Rab_GDP_dissociation_inhibitors subject Category:Protein_families.
- Rab_GDP_dissociation_inhibitors type Biomolecule.
- Rab_GDP_dissociation_inhibitors type Protein.
- Rab_GDP_dissociation_inhibitors type Chemical.
- Rab_GDP_dissociation_inhibitors type Thing.
- Rab_GDP_dissociation_inhibitors type Q206229.
- Rab_GDP_dissociation_inhibitors type Q8054.
- Rab_GDP_dissociation_inhibitors comment "In molecular biology, the Rab GDP dissociation inhibitors (Rab GDIs) constitute a family of small GTPases that serve a regulatory role in vesicular membrane traffic. C-terminal geranylgeranylation is crucial for their membrane association and function. This post-translational modification is catalysed by Rab geranylgeranyl transferase (Rab-GGTase), a multi-subunit enzyme that contains a catalytic heterodimer and an accessory component, termed Rab escort protein (REP)-1.".
- Rab_GDP_dissociation_inhibitors label "Rab GDP dissociation inhibitors".
- Rab_GDP_dissociation_inhibitors sameAs Q7278456.
- Rab_GDP_dissociation_inhibitors sameAs m.0h52gvc.
- Rab_GDP_dissociation_inhibitors sameAs Q7278456.
- Rab_GDP_dissociation_inhibitors wasDerivedFrom Rab_GDP_dissociation_inhibitors?oldid=592889975.
- Rab_GDP_dissociation_inhibitors depiction PDB_2bcg_EBI.jpg.
- Rab_GDP_dissociation_inhibitors isPrimaryTopicOf Rab_GDP_dissociation_inhibitors.