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- RTI-31 abstract "(–)-2β-Carbomethoxy-3β-(4'-chlorophenyl)tropane (RTI-31) is a synthetic analog of cocaine that acts as a stimulant. Semi-synthesis of this compound is dependent upon the availability of cocaine starting material. According to the article, RTI-31 is 64 x the strength of cocaine in terms of its potency to elicit self-administration in monkeys. WIN 35428 was 6 x weaker than RTI-31, whereas RTI-51 was 2.6 x weaker than RTI-31.A further advantage, in addition to potency of this compound, is that its duration of activity is longer than for cocaine. It could therefore be considered within the context as an agonist based therapy for treating cocaine addiction, although it is actually RTI-336 that entered into clinical trials with this in mind. RTI-31 is already completely psychoactive in its own right meaning that further chemical manipulation should be viewed as an option that is not strictly necessary. RTI-336 is actually made using RTI-31 as starting material. As will be seen in the next section, RTI-31 is not an entirely selective DRI in that it also has appreciable SERT and NET blocking affinity. RTI-31 can easily be \"cleaned\" though, as is done, for instance, by replacing the carbomethoxy ester with a more sterically occluded substituent such as is done for RTI-113.".
- RTI-31 casNumber "130342-80-2".
- RTI-31 iupacName "methyl (1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate".
- RTI-31 pubchem "131195".
- RTI-31 thumbnail Chlorophenyltropane.png?width=300.
- RTI-31 wikiPageID "23715160".
- RTI-31 wikiPageLength "11553".
- RTI-31 wikiPageOutDegree "42".
- RTI-31 wikiPageRevisionID "706834050".
- RTI-31 wikiPageWikiLink (+)-CPCA.
- RTI-31 wikiPageWikiLink (-)-2β-(3-(4-Methylphenyl)isoxazol-5-yl)-3β-(4-chlorophenyl)tropane.
- RTI-31 wikiPageWikiLink Binding_constant.
- RTI-31 wikiPageWikiLink Category:Chloroarenes.
- RTI-31 wikiPageWikiLink Category:Dopamine_reuptake_inhibitors.
- RTI-31 wikiPageWikiLink Category:RTI_compounds.
- RTI-31 wikiPageWikiLink Category:Sympathomimetic_amines.
- RTI-31 wikiPageWikiLink Category:Tropanes.
- RTI-31 wikiPageWikiLink Cf..
- RTI-31 wikiPageWikiLink Cocaine.
- RTI-31 wikiPageWikiLink Dichloropane.
- RTI-31 wikiPageWikiLink Dissociation_constant.
- RTI-31 wikiPageWikiLink Dopaminergic.
- RTI-31 wikiPageWikiLink IC50.
- RTI-31 wikiPageWikiLink Lipophilicity.
- RTI-31 wikiPageWikiLink Monoamine_transporter.
- RTI-31 wikiPageWikiLink Nisoxetine.
- RTI-31 wikiPageWikiLink Norepinephrine.
- RTI-31 wikiPageWikiLink Paroxetine.
- RTI-31 wikiPageWikiLink Phenyltropane.
- RTI-31 wikiPageWikiLink RTI-113.
- RTI-31 wikiPageWikiLink RTI-32.
- RTI-31 wikiPageWikiLink RTI-51.
- RTI-31 wikiPageWikiLink RTI-55.
- RTI-31 wikiPageWikiLink Radioactive_tracer.
- RTI-31 wikiPageWikiLink Serotonergic.
- RTI-31 wikiPageWikiLink Stereochemistry.
- RTI-31 wikiPageWikiLink Stimulant.
- RTI-31 wikiPageWikiLink Structural_analog.
- RTI-31 wikiPageWikiLink Troparil.
- RTI-31 wikiPageWikiLink WIN_35428.
- RTI-31 wikiPageWikiLink File:Compound_5.png.
- RTI-31 wikiPageWikiLink File:RTI-31_analogues.svg.
- RTI-31 wikiPageWikiLinkText "RTI-31".
- RTI-31 c "16".
- RTI-31 casNumber "130342".
- RTI-31 cl "1".
- RTI-31 h "20".
- RTI-31 iupacName "methyl -3--8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate".
- RTI-31 molecularWeight "293.12".
- RTI-31 n "1".
- RTI-31 o "2".
- RTI-31 pubchem "131195".
- RTI-31 smiles "CN1[C@H]2CC[C@@H]1[C@H]COC".
- RTI-31 verifiedrevid "449586151".
- RTI-31 wikiPageUsesTemplate Template:Cascite.
- RTI-31 wikiPageUsesTemplate Template:Cite_journal.
- RTI-31 wikiPageUsesTemplate Template:Cquote.
- RTI-31 wikiPageUsesTemplate Template:Dopaminergics.
- RTI-31 wikiPageUsesTemplate Template:Drugbox.
- RTI-31 wikiPageUsesTemplate Template:Phenyltropanes.
- RTI-31 wikiPageUsesTemplate Template:Reflist.
- RTI-31 wikiPageUsesTemplate Template:Stimulants.
- RTI-31 subject Category:Chloroarenes.
- RTI-31 subject Category:Dopamine_reuptake_inhibitors.
- RTI-31 subject Category:RTI_compounds.
- RTI-31 subject Category:Sympathomimetic_amines.
- RTI-31 subject Category:Tropanes.
- RTI-31 hypernym Analog.
- RTI-31 type ChemicalSubstance.
- RTI-31 type Drug.
- RTI-31 type Alkaloid.
- RTI-31 type Chemical.
- RTI-31 type Drug.
- RTI-31 type Ester.
- RTI-31 type Heterocycle.
- RTI-31 type Inhibitor.
- RTI-31 type Organohalide.
- RTI-31 type Psychoanaleptic.
- RTI-31 type Stimulant.
- RTI-31 type Sympathomimetic.
- RTI-31 type Organohalide.
- RTI-31 type ChemicalObject.
- RTI-31 type Thing.
- RTI-31 type Q8386.
- RTI-31 comment "(–)-2β-Carbomethoxy-3β-(4'-chlorophenyl)tropane (RTI-31) is a synthetic analog of cocaine that acts as a stimulant. Semi-synthesis of this compound is dependent upon the availability of cocaine starting material. According to the article, RTI-31 is 64 x the strength of cocaine in terms of its potency to elicit self-administration in monkeys.".
- RTI-31 label "RTI-31".
- RTI-31 sameAs Q7277834.
- RTI-31 sameAs m.06znv1c.
- RTI-31 sameAs RTI-31.
- RTI-31 sameAs RTI-31.
- RTI-31 sameAs Q7277834.
- RTI-31 wasDerivedFrom RTI-31?oldid=706834050.
- RTI-31 depiction Chlorophenyltropane.png.
- RTI-31 isPrimaryTopicOf RTI-31.