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- RNA-induced_transcriptional_silencing abstract "RNA-induced transcriptional silencing (RITS) is a form of RNA interference by which short RNA molecules - such as small interfering RNA (siRNA) - trigger the downregulation of transcription of a particular gene or genomic region. This is usually accomplished by posttranslational modification of histone tails (e.g. methylation of lysine 9 of histone H3) which target the genomic region for heterochromatin formation. The protein complex that binds to siRNAs and interacts with the methylated lysine 9 residue of histones H3 is the RITS complex.RITS was discovered in the fission yeast Schizosaccharomyces pombe, and has been shown to be involved in the initiation and spreading of heterochromatin in the mating-type region and in centromere formation. The RITS complex in S. pombe contains at least a piwi domain-containing RNase H-like argonaute, a chromodomain protein Chp1, and an argonaute interacting protein Tas3 which can also bind to Chp1, while heterochromatin formation has been shown to require at least argonaute and an RNA-dependent RNA polymerase. Loss of these genes in S. pombe results in abnormal heterochromatin organization and formation of the chromosome centromeres, resulting in slow or stalled anaphase during cell division.The maintenance of heterochromatin regions by RITS complexes has been described as a self-reinforcing feedback loop, in which RITS complexes stably bind the methylated histones of a heterochromatin region and induce co-transcriptional degradation of any nascent messenger RNA (mRNA) transcripts, which are then used as RNA-dependent RNA polymerase substrates to replenish the complement of siRNA molecules. Heterochromatin formation, but possibly not maintenance, is dependent on the ribonuclease protein dicer, which is used to generate the initial complement of siRNAs.The relevance of observations from fission yeast mating-type regions and centromeres to mammals is not clear, as some evidence suggests that heterochromatin maintenance in mammalian cells is independent of the components of the RNAi pathway.".
- RNA-induced_transcriptional_silencing wikiPageID "9432643".
- RNA-induced_transcriptional_silencing wikiPageLength "4704".
- RNA-induced_transcriptional_silencing wikiPageOutDegree "30".
- RNA-induced_transcriptional_silencing wikiPageRevisionID "487190650".
- RNA-induced_transcriptional_silencing wikiPageWikiLink Anaphase.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Argonaute.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Category:Gene_expression.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Category:RNA.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Cell_division.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Centromere.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Chromodomain.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Chromosome.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Dicer.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Feedback.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Gene.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Genome.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Heterochromatin.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Histone.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Mammal.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Mating-type_region.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Messenger_RNA.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Multiprotein_complex.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Piwi.
- RNA-induced_transcriptional_silencing wikiPageWikiLink RNA.
- RNA-induced_transcriptional_silencing wikiPageWikiLink RNA-dependent_RNA_polymerase.
- RNA-induced_transcriptional_silencing wikiPageWikiLink RNA_interference.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Ribonuclease.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Ribonuclease_H.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Schizosaccharomyces_pombe.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Small_interfering_RNA.
- RNA-induced_transcriptional_silencing wikiPageWikiLink Transcription_(genetics).
- RNA-induced_transcriptional_silencing wikiPageWikiLinkText "RNA-induced transcriptional silencing complex".
- RNA-induced_transcriptional_silencing wikiPageWikiLinkText "RNA-induced transcriptional silencing".
- RNA-induced_transcriptional_silencing wikiPageWikiLinkText "decreasing".
- RNA-induced_transcriptional_silencing wikiPageUsesTemplate Template:Cell-biology-stub.
- RNA-induced_transcriptional_silencing subject Category:Gene_expression.
- RNA-induced_transcriptional_silencing subject Category:RNA.
- RNA-induced_transcriptional_silencing hypernym Form.
- RNA-induced_transcriptional_silencing type Process.
- RNA-induced_transcriptional_silencing comment "RNA-induced transcriptional silencing (RITS) is a form of RNA interference by which short RNA molecules - such as small interfering RNA (siRNA) - trigger the downregulation of transcription of a particular gene or genomic region. This is usually accomplished by posttranslational modification of histone tails (e.g. methylation of lysine 9 of histone H3) which target the genomic region for heterochromatin formation.".
- RNA-induced_transcriptional_silencing label "RNA-induced transcriptional silencing".
- RNA-induced_transcriptional_silencing sameAs Q7277128.
- RNA-induced_transcriptional_silencing sameAs m.0288rmx.
- RNA-induced_transcriptional_silencing sameAs Q7277128.
- RNA-induced_transcriptional_silencing wasDerivedFrom RNA-induced_transcriptional_silencing?oldid=487190650.
- RNA-induced_transcriptional_silencing isPrimaryTopicOf RNA-induced_transcriptional_silencing.