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- RHO_protein_GDP_dissociation_inhibitor abstract "RHO protein GDP dissociation inhibitor of Rho proteins (rho GDI), regulates GDP/GTP exchange.The protein plays an important role in the activation of the oxygen superoxide-generating NADPH oxidase of phagocytes. This process requires the interaction of membrane-associated cytochrome b559 with 3 cytosolic components: p47-phox, p67-phox and a heterodimer of the small G-protein p21Rac1 and rho GDI. The association of p21rac and GDI inhibits dissociation of GDP from p21rac, thereby maintaining it in an inactive form. The proteins are attached via a lipid tail on p21rac that binds to the hydrophobic region of GDI. Dissociation of these proteins might be mediated by the release of lipids (e.g., arachidonate and phosphatidate) from membranes through the action of phospholipases. The lipids may then compete with the lipid tail on p21rac for the hydrophobic pocket on GDI.".
- RHO_protein_GDP_dissociation_inhibitor symbol "Rho_GDI".
- RHO_protein_GDP_dissociation_inhibitor thumbnail PDB_1rho_EBI.jpg?width=300.
- RHO_protein_GDP_dissociation_inhibitor wikiPageID "14708457".
- RHO_protein_GDP_dissociation_inhibitor wikiPageLength "2983".
- RHO_protein_GDP_dissociation_inhibitor wikiPageOutDegree "20".
- RHO_protein_GDP_dissociation_inhibitor wikiPageRevisionID "704775345".
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink ARHGDIA.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink ARHGDIB.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink ARHGDIG.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Arachidonic_acid.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Category:Peripheral_membrane_proteins.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Category:Protein_domains.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Cytochrome_b559.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Cytoplasm.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink G_protein.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Guanosine_diphosphate.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Guanosine_triphosphate.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink NADPH_oxidase.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Neutrophil_cytosolic_factor_1.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Neutrophil_cytosolic_factor_2.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Phagocyte.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Phosphatidic_acid.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Phospholipase.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink RAC1.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Rho_family_of_GTPases.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLink Superoxide.
- RHO_protein_GDP_dissociation_inhibitor wikiPageWikiLinkText "RHO protein GDP dissociation inhibitor".
- RHO_protein_GDP_dissociation_inhibitor caption "Structure of RHO guanine nucleotide dissociation inhibitor.".
- RHO_protein_GDP_dissociation_inhibitor interpro "IPR000406".
- RHO_protein_GDP_dissociation_inhibitor name "RHO protein GDP dissociation inhibitor".
- RHO_protein_GDP_dissociation_inhibitor opmFamily "99".
- RHO_protein_GDP_dissociation_inhibitor opmProtein "1".
- RHO_protein_GDP_dissociation_inhibitor pdb "B:23-201 :60-204 :60-204 B:1-204 C:67-204 A:67-204 B:67-204 A:59-203 F:1-204 B:24-204 A:67-204 D:1-204 A:67-204 B:67-204".
- RHO_protein_GDP_dissociation_inhibitor pfam "PF02115".
- RHO_protein_GDP_dissociation_inhibitor scop "1".
- RHO_protein_GDP_dissociation_inhibitor symbol "Rho_GDI".
- RHO_protein_GDP_dissociation_inhibitor wikiPageUsesTemplate Template:InterPro_content.
- RHO_protein_GDP_dissociation_inhibitor wikiPageUsesTemplate Template:Membrane-protein-stub.
- RHO_protein_GDP_dissociation_inhibitor wikiPageUsesTemplate Template:PDB3.
- RHO_protein_GDP_dissociation_inhibitor wikiPageUsesTemplate Template:Pfam_box.
- RHO_protein_GDP_dissociation_inhibitor wikiPageUsesTemplate Template:Reflist.
- RHO_protein_GDP_dissociation_inhibitor subject Category:Peripheral_membrane_proteins.
- RHO_protein_GDP_dissociation_inhibitor subject Category:Protein_domains.
- RHO_protein_GDP_dissociation_inhibitor type Biomolecule.
- RHO_protein_GDP_dissociation_inhibitor type Protein.
- RHO_protein_GDP_dissociation_inhibitor type Chemical.
- RHO_protein_GDP_dissociation_inhibitor type Domain.
- RHO_protein_GDP_dissociation_inhibitor type Thing.
- RHO_protein_GDP_dissociation_inhibitor type Q206229.
- RHO_protein_GDP_dissociation_inhibitor type Q8054.
- RHO_protein_GDP_dissociation_inhibitor comment "RHO protein GDP dissociation inhibitor of Rho proteins (rho GDI), regulates GDP/GTP exchange.The protein plays an important role in the activation of the oxygen superoxide-generating NADPH oxidase of phagocytes. This process requires the interaction of membrane-associated cytochrome b559 with 3 cytosolic components: p47-phox, p67-phox and a heterodimer of the small G-protein p21Rac1 and rho GDI.".
- RHO_protein_GDP_dissociation_inhibitor label "RHO protein GDP dissociation inhibitor".
- RHO_protein_GDP_dissociation_inhibitor sameAs Q7276729.
- RHO_protein_GDP_dissociation_inhibitor sameAs m.03gtwng.
- RHO_protein_GDP_dissociation_inhibitor sameAs Q7276729.
- RHO_protein_GDP_dissociation_inhibitor wasDerivedFrom RHO_protein_GDP_dissociation_inhibitor?oldid=704775345.
- RHO_protein_GDP_dissociation_inhibitor depiction PDB_1rho_EBI.jpg.
- RHO_protein_GDP_dissociation_inhibitor isPrimaryTopicOf RHO_protein_GDP_dissociation_inhibitor.