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- RAB1 abstract "Rab GTPases are molecular switches that regulate membrane traffic. They are active in their GTP-bound form and inactive when bound to GDP. The GTPase YPT1, and its mammalian homologue Rab1, regulate membrane-tethering events on three different pathways: autophagy, ER-Golgi, and intra-Golgi traffic. In the yeast Saccharomyces cerevisiae, many of the ATG proteins needed for macroautophagy are shared with the biosynthetic cytoplasm to the vacuole-targeting (CVT) pathway that transports certain hydrolases into the vacuole. Both pathways require YPT1; however, only the macroautophagy pathway is conserved in higher eukaryotes. In the macroautophagy pathway, Rab1 mediates the recruitment of Atg1 to the PAS. Rab1 regulates macroautophagy by recruiting its effector, Atg1, to the PAS to tether Atg9 vesicles to each other or to other membranes.".
- RAB1 wikiPageID "44654810".
- RAB1 wikiPageLength "2162".
- RAB1 wikiPageOutDegree "20".
- RAB1 wikiPageRevisionID "649552898".
- RAB1 wikiPageWikiLink Autophagy.
- RAB1 wikiPageWikiLink Biosynthesis.
- RAB1 wikiPageWikiLink Category:Membrane_biology.
- RAB1 wikiPageWikiLink Cytoplasm.
- RAB1 wikiPageWikiLink Cytoplasm-to-vacuole_targeting.
- RAB1 wikiPageWikiLink Eukaryote.
- RAB1 wikiPageWikiLink GTPase.
- RAB1 wikiPageWikiLink Golgi_apparatus.
- RAB1 wikiPageWikiLink Guanosine_diphosphate.
- RAB1 wikiPageWikiLink Guanosine_triphosphate.
- RAB1 wikiPageWikiLink Hydrolase.
- RAB1 wikiPageWikiLink Mammal.
- RAB1 wikiPageWikiLink Membrane.
- RAB1 wikiPageWikiLink Molecule.
- RAB1 wikiPageWikiLink Protein.
- RAB1 wikiPageWikiLink Saccharomyces_cerevisiae.
- RAB1 wikiPageWikiLink Vacuole.
- RAB1 wikiPageWikiLink Vesicle_(biology_and_chemistry).
- RAB1 wikiPageWikiLink Yeast.
- RAB1 wikiPageWikiLinkText "RAB1".
- RAB1 wikiPageUsesTemplate Template:Reflist.
- RAB1 subject Category:Membrane_biology.
- RAB1 hypernym Switches.
- RAB1 comment "Rab GTPases are molecular switches that regulate membrane traffic. They are active in their GTP-bound form and inactive when bound to GDP. The GTPase YPT1, and its mammalian homologue Rab1, regulate membrane-tethering events on three different pathways: autophagy, ER-Golgi, and intra-Golgi traffic.".
- RAB1 label "RAB1".
- RAB1 sameAs Q18648845.
- RAB1 sameAs Rab1.
- RAB1 sameAs m.012gbhz0.
- RAB1 sameAs Q18648845.
- RAB1 wasDerivedFrom RAB1?oldid=649552898.
- RAB1 isPrimaryTopicOf RAB1.