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- Pyroptosis abstract "Pyroptosis is a form of programmed cell death associated with antimicrobial responses during inflammation. In this process, immune cells that recognize certain danger signals within themselves produce cytokines, swell, burst and die. This releases the cytokines, attracts other immune cells to fight the infection and contributes to inflammation. Some examples of pyroptosis include salmonella-infected macrophages and abortively HIV-infected T helper cells.The initiation of pyroptosis is caused by the recognition of flagellin components of Salmonella and Shigella species (and similar pathogen-associated molecular patterns (PAMPs) in other microbial pathogens) by NOD-like receptors (NLRs). These receptors function like plasma membrane Toll-like receptors (TLRs), but recognise antigens located within the cell rather than outside of it.In contrast to apoptosis, pyroptosis requires the function of the enzyme caspase-1. Caspase-1 is activated during pyroptosis by a large supramolecular complex termed the pyroptosome (also known as an inflammasome). Only one large pyroptosome is formed in each macrophage, within minutes after infection. Biochemical and Mass Spectroscopic analysis revealed that this pyroptosome is largely composed of dimers of the adaptor protein ASC (apoptosis-associated speck protein containing a CARD or Caspase activation and recruitment domain).Unlike apoptosis, pyroptosis results in the release of damage-associated molecular pattern (DAMP) molecules and cytokines that activate pro-inflammatory immune cell mediators.".
- Pyroptosis thumbnail Pyroptosis_mechanism.png?width=300.
- Pyroptosis wikiPageID "8948754".
- Pyroptosis wikiPageLength "24120".
- Pyroptosis wikiPageOutDegree "62".
- Pyroptosis wikiPageRevisionID "705917749".
- Pyroptosis wikiPageWikiLink Adaptive_immune_system.
- Pyroptosis wikiPageWikiLink Antimicrobial.
- Pyroptosis wikiPageWikiLink Apoptosis.
- Pyroptosis wikiPageWikiLink Beta_cell.
- Pyroptosis wikiPageWikiLink CARD_domain.
- Pyroptosis wikiPageWikiLink Caspase_1.
- Pyroptosis wikiPageWikiLink Category:Programmed_cell_death.
- Pyroptosis wikiPageWikiLink Cold_urticaria.
- Pyroptosis wikiPageWikiLink Cytokine.
- Pyroptosis wikiPageWikiLink DNA_fragmentation.
- Pyroptosis wikiPageWikiLink Damage-associated_molecular_pattern.
- Pyroptosis wikiPageWikiLink Diabetes_mellitus_type_2.
- Pyroptosis wikiPageWikiLink Electrochemistry.
- Pyroptosis wikiPageWikiLink Endosome.
- Pyroptosis wikiPageWikiLink File:Inflammasome_final1.png.
- Pyroptosis wikiPageWikiLink File:Pyroptosis_mechanism.png.
- Pyroptosis wikiPageWikiLink Flagellin.
- Pyroptosis wikiPageWikiLink Glucose.
- Pyroptosis wikiPageWikiLink HIV.
- Pyroptosis wikiPageWikiLink Inborn_error_of_metabolism.
- Pyroptosis wikiPageWikiLink Inflammasome.
- Pyroptosis wikiPageWikiLink Inflammation.
- Pyroptosis wikiPageWikiLink Injury.
- Pyroptosis wikiPageWikiLink Insulin.
- Pyroptosis wikiPageWikiLink Insulin_resistance.
- Pyroptosis wikiPageWikiLink Interferon_regulatory_factors.
- Pyroptosis wikiPageWikiLink Interferon_type_I.
- Pyroptosis wikiPageWikiLink Leucine-rich_repeat.
- Pyroptosis wikiPageWikiLink Macrophage.
- Pyroptosis wikiPageWikiLink Microorganism.
- Pyroptosis wikiPageWikiLink Mitogen-activated_protein_kinase.
- Pyroptosis wikiPageWikiLink Morphology_(biology).
- Pyroptosis wikiPageWikiLink Muckle–Wells_syndrome.
- Pyroptosis wikiPageWikiLink NALP3.
- Pyroptosis wikiPageWikiLink NF-κB.
- Pyroptosis wikiPageWikiLink NOD-like_receptor.
- Pyroptosis wikiPageWikiLink NOD1.
- Pyroptosis wikiPageWikiLink NOD2.
- Pyroptosis wikiPageWikiLink Necrosis.
- Pyroptosis wikiPageWikiLink Neonatal_onset_multisystem_inflammatory_disease.
- Pyroptosis wikiPageWikiLink Obesity.
- Pyroptosis wikiPageWikiLink Osmotic_pressure.
- Pyroptosis wikiPageWikiLink PYCARD.
- Pyroptosis wikiPageWikiLink Pathogen-associated_molecular_pattern.
- Pyroptosis wikiPageWikiLink Pattern_recognition_receptor.
- Pyroptosis wikiPageWikiLink Programmed_cell_death.
- Pyroptosis wikiPageWikiLink Pyrin_domain.
- Pyroptosis wikiPageWikiLink Salmonella.
- Pyroptosis wikiPageWikiLink Shigella.
- Pyroptosis wikiPageWikiLink T_helper_cell.
- Pyroptosis wikiPageWikiLink Toll-like_receptor.
- Pyroptosis wikiPageWikiLink Transcription_factor.
- Pyroptosis wikiPageWikiLink Tumor_necrosis_factors.
- Pyroptosis wikiPageWikiLink White_blood_cell.
- Pyroptosis wikiPageWikiLink Zymogen.
- Pyroptosis wikiPageWikiLinkText "Pyroptosis".
- Pyroptosis wikiPageWikiLinkText "pro-IL-1β".
- Pyroptosis wikiPageWikiLinkText "pyroptosis".
- Pyroptosis wikiPageUsesTemplate Template:Reflist.
- Pyroptosis subject Category:Programmed_cell_death.
- Pyroptosis hypernym Form.
- Pyroptosis type Process.
- Pyroptosis comment "Pyroptosis is a form of programmed cell death associated with antimicrobial responses during inflammation. In this process, immune cells that recognize certain danger signals within themselves produce cytokines, swell, burst and die. This releases the cytokines, attracts other immune cells to fight the infection and contributes to inflammation.".
- Pyroptosis label "Pyroptosis".
- Pyroptosis sameAs Q7263707.
- Pyroptosis sameAs m.027qv8l.
- Pyroptosis sameAs Пироптоз.
- Pyroptosis sameAs Q7263707.
- Pyroptosis wasDerivedFrom Pyroptosis?oldid=705917749.
- Pyroptosis depiction Pyroptosis_mechanism.png.
- Pyroptosis isPrimaryTopicOf Pyroptosis.