Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Proteopathy> ?p ?o }
- Proteopathy abstract "In medicine, proteopathy (Proteo- [pref. protein]; -pathy [suff. disease]; proteopathies pl.; proteopathic adj.) refers to a class of diseases in which certain proteins become structurally abnormal, and thereby disrupt the function of cells, tissues and organs of the body. Often the proteins fail to fold into their normal configuration; in this misfolded state, the proteins can become toxic in some way (a gain of toxic function) or they can lose their normal function. The proteopathies (also known as proteinopathies, protein conformational disorders, or protein misfolding diseases) include such diseases as Creutzfeldt–Jakob disease, Alzheimer's disease, Parkinson's disease, prion disease, amyloidosis, and a wide range of other disorders (see List of Proteopathies).The concept of proteopathy can trace its origins to the mid-19th century, when, in 1854, Rudolf Virchow coined the term amyloid (\"starch-like\") to describe a substance in cerebral corpora amylacea that exhibited a chemical reaction resembling that of cellulose. In 1859, Friedreich and Kekulé demonstrated that, rather than consisting of cellulose, \"amyloid\" actually is rich in protein. Subsequent research has shown that many different proteins can form amyloid, and that all amyloids have in common birefringence in cross-polarized light after staining with the dye Congo Red, as well as a fibrillar ultrastructure when viewed with an electron microscope. However, some proteinaceous lesions lack birefringence and contain few or no classical amyloid fibrils, such as the diffuse deposits of Aβ protein in the brains of Alzheimer patients. Furthermore, evidence has emerged that small, non-fibrillar protein aggregates known as oligomers are toxic to the cells of an affected organ, and that amyloidogenic proteins in their fibrillar form may be relatively benign.".
- Proteopathy thumbnail Proteopathy_Abeta_deposits_in_Alzheimer_disease.jpg?width=300.
- Proteopathy wikiPageExternalLink topic19.htm.
- Proteopathy wikiPageExternalLink topic3377.htm.
- Proteopathy wikiPageExternalLink topic662.htm.
- Proteopathy wikiPageID "10348140".
- Proteopathy wikiPageLength "24121".
- Proteopathy wikiPageOutDegree "158".
- Proteopathy wikiPageRevisionID "705905484".
- Proteopathy wikiPageWikiLink Alexander_disease.
- Proteopathy wikiPageWikiLink Alpha-synuclein.
- Proteopathy wikiPageWikiLink Alzheimers_disease.
- Proteopathy wikiPageWikiLink Amino_acid.
- Proteopathy wikiPageWikiLink Amylin.
- Proteopathy wikiPageWikiLink Amyloid.
- Proteopathy wikiPageWikiLink Amyloid_beta.
- Proteopathy wikiPageWikiLink Amyloidosis.
- Proteopathy wikiPageWikiLink Amyotrophic_lateral_sclerosis.
- Proteopathy wikiPageWikiLink Antibody.
- Proteopathy wikiPageWikiLink Apolipoprotein.
- Proteopathy wikiPageWikiLink Apolipoprotein_A1.
- Proteopathy wikiPageWikiLink Atrial_natriuretic_peptide.
- Proteopathy wikiPageWikiLink August_Kekulé.
- Proteopathy wikiPageWikiLink Beta-2_microglobulin.
- Proteopathy wikiPageWikiLink Beta_sheet.
- Proteopathy wikiPageWikiLink Birefringence.
- Proteopathy wikiPageWikiLink CADASIL_syndrome.
- Proteopathy wikiPageWikiLink Calcifying_epithelial_odontogenic_tumor.
- Proteopathy wikiPageWikiLink Calcitonin.
- Proteopathy wikiPageWikiLink Carcinoma.
- Proteopathy wikiPageWikiLink Cataract.
- Proteopathy wikiPageWikiLink Category:Neurological_disorders.
- Proteopathy wikiPageWikiLink Category:Pathology.
- Proteopathy wikiPageWikiLink Category:Protein_folding.
- Proteopathy wikiPageWikiLink Cell_(biology).
- Proteopathy wikiPageWikiLink Cellulose.
- Proteopathy wikiPageWikiLink Cerebral_amyloid_angiopathy.
- Proteopathy wikiPageWikiLink Cerebral_hemorrhage.
- Proteopathy wikiPageWikiLink Congo_red.
- Proteopathy wikiPageWikiLink Corneal_dystrophy.
- Proteopathy wikiPageWikiLink Corpora_amylacea.
- Proteopathy wikiPageWikiLink Creutzfeldt–Jakob_disease.
- Proteopathy wikiPageWikiLink Crystallin.
- Proteopathy wikiPageWikiLink Curli.
- Proteopathy wikiPageWikiLink Cystatin_C.
- Proteopathy wikiPageWikiLink Cystic_fibrosis.
- Proteopathy wikiPageWikiLink Cystic_fibrosis_transmembrane_conductance_regulator.
- Proteopathy wikiPageWikiLink Dementia.
- Proteopathy wikiPageWikiLink Diabetes_mellitus_type_2.
- Proteopathy wikiPageWikiLink Dialysis.
- Proteopathy wikiPageWikiLink Disease.
- Proteopathy wikiPageWikiLink Electron_microscope.
- Proteopathy wikiPageWikiLink Escherichia_coli.
- Proteopathy wikiPageWikiLink FUS.
- Proteopathy wikiPageWikiLink Fibrinogen.
- Proteopathy wikiPageWikiLink File:Proteopathy_Abeta_deposits_in_Alzheimer_disease.jpg.
- Proteopathy wikiPageWikiLink Frontotemporal_lobar_degeneration.
- Proteopathy wikiPageWikiLink Gelsolin.
- Proteopathy wikiPageWikiLink Glaucoma.
- Proteopathy wikiPageWikiLink Glial_fibrillary_acidic_protein.
- Proteopathy wikiPageWikiLink Glutamine.
- Proteopathy wikiPageWikiLink Hemoglobin.
- Proteopathy wikiPageWikiLink Host_(biology).
- Proteopathy wikiPageWikiLink Huntingtons_disease.
- Proteopathy wikiPageWikiLink Hyperphosphorylation.
- Proteopathy wikiPageWikiLink Inclusion_body_myositis.
- Proteopathy wikiPageWikiLink Intermediate_filament.
- Proteopathy wikiPageWikiLink Keratin.
- Proteopathy wikiPageWikiLink Lactoferrin.
- Proteopathy wikiPageWikiLink Lewy_body.
- Proteopathy wikiPageWikiLink Lysozyme.
- Proteopathy wikiPageWikiLink Macromolecule.
- Proteopathy wikiPageWikiLink Mallory_body.
- Proteopathy wikiPageWikiLink Medicine.
- Proteopathy wikiPageWikiLink Monomer.
- Proteopathy wikiPageWikiLink Myopathy.
- Proteopathy wikiPageWikiLink Myosin.
- Proteopathy wikiPageWikiLink Neurofibrillary_tangle.
- Proteopathy wikiPageWikiLink Nikolaus_Friedreich.
- Proteopathy wikiPageWikiLink Notch_proteins.
- Proteopathy wikiPageWikiLink ODAM_(gene).
- Proteopathy wikiPageWikiLink Oligomer.
- Proteopathy wikiPageWikiLink Organ_(anatomy).
- Proteopathy wikiPageWikiLink PH.
- Proteopathy wikiPageWikiLink PRNP.
- Proteopathy wikiPageWikiLink Parkinsons_disease.
- Proteopathy wikiPageWikiLink Peptide.
- Proteopathy wikiPageWikiLink Peripheral_neuropathy.
- Proteopathy wikiPageWikiLink Pituitary_gland.
- Proteopathy wikiPageWikiLink Polarization_(waves).
- Proteopathy wikiPageWikiLink Post-translational_modification.
- Proteopathy wikiPageWikiLink Prolactin.
- Proteopathy wikiPageWikiLink Protein.
- Proteopathy wikiPageWikiLink Pulmonary_alveolar_proteinosis.
- Proteopathy wikiPageWikiLink Retinal_ganglion_cell.
- Proteopathy wikiPageWikiLink Retinitis_pigmentosa.
- Proteopathy wikiPageWikiLink Rhodopsin.
- Proteopathy wikiPageWikiLink Risk_factor.
- Proteopathy wikiPageWikiLink Rudolf_Virchow.
- Proteopathy wikiPageWikiLink Semenogelin_I.