Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Proteasome> ?p ?o }
- Proteasome abstract "Proteasomes are protein complexes inside all eukaryotes and archaea, and in some bacteria. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.In eukaryotes, proteasomes are located in the nucleus and the cytoplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into shorter amino acid sequences and used in synthesizing new proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein.In structure, the proteasome is a cylindrical complex containing a \"core\" of four stacked rings forming a central pore. Each ring is composed of seven individual proteins. The inner two rings are made of seven β subunits that contain three to seven protease active sites. These sites are located on the interior surface of the rings, so that the target protein must enter the central pore before it is degraded. The outer two rings each contain seven α subunits whose function is to maintain a \"gate\" through which proteins enter the barrel. These α subunits are controlled by binding to \"cap\" structures or regulatory particles that recognize polyubiquitin tags attached to protein substrates and initiate the degradation process. The overall system of ubiquitination and proteasomal degradation is known as the ubiquitin-proteasome system.The proteasomal degradation pathway is essential for many cellular processes, including the cell cycle, the regulation of gene expression, and responses to oxidative stress. The importance of proteolytic degradation inside cells and the role of ubiquitin in proteolytic pathways was acknowledged in the award of the 2004 Nobel Prize in Chemistry to Aaron Ciechanover, Avram Hershko and Irwin Rose.".
- Proteasome thumbnail Proteaosome_1fnt_side.png?width=300.
- Proteasome wikiPageExternalLink proteasome_units.html.
- Proteasome wikiPageExternalLink 0010B.SGM.
- Proteasome wikiPageExternalLink proteasome*.
- Proteasome wikiPageExternalLink proteasome-nomenclature-guide.
- Proteasome wikiPageID "24603".
- Proteasome wikiPageLength "91732".
- Proteasome wikiPageOutDegree "332".
- Proteasome wikiPageRevisionID "707504676".
- Proteasome wikiPageWikiLink AAA_proteins.
- Proteasome wikiPageWikiLink ABL_(gene).
- Proteasome wikiPageWikiLink ATPase.
- Proteasome wikiPageWikiLink Aaron_Ciechanover.
- Proteasome wikiPageWikiLink Acid.
- Proteasome wikiPageWikiLink Actinomycetales.
- Proteasome wikiPageWikiLink Active_site.
- Proteasome wikiPageWikiLink Adaptive_immune_system.
- Proteasome wikiPageWikiLink Adenomatous_polyposis_coli.
- Proteasome wikiPageWikiLink Adenosine_triphosphate.
- Proteasome wikiPageWikiLink Ageing.
- Proteasome wikiPageWikiLink Alanine.
- Proteasome wikiPageWikiLink Alfred_Goldberg.
- Proteasome wikiPageWikiLink Alpha-synuclein.
- Proteasome wikiPageWikiLink Alpha_helix.
- Proteasome wikiPageWikiLink Alzheimers_disease.
- Proteasome wikiPageWikiLink Amino_acid.
- Proteasome wikiPageWikiLink Amyotrophic_lateral_sclerosis.
- Proteasome wikiPageWikiLink Anaphase-promoting_complex.
- Proteasome wikiPageWikiLink Androgen_receptor.
- Proteasome wikiPageWikiLink Antigen.
- Proteasome wikiPageWikiLink Antigen-presenting_cell.
- Proteasome wikiPageWikiLink Antigen_presentation.
- Proteasome wikiPageWikiLink Apoptosis.
- Proteasome wikiPageWikiLink Archaea.
- Proteasome wikiPageWikiLink Asthma.
- Proteasome wikiPageWikiLink Astrocytoma.
- Proteasome wikiPageWikiLink Atomic_mass_unit.
- Proteasome wikiPageWikiLink Autism_spectrum.
- Proteasome wikiPageWikiLink Autoimmune_disease.
- Proteasome wikiPageWikiLink Autolysis_(biology).
- Proteasome wikiPageWikiLink Auxin.
- Proteasome wikiPageWikiLink Avram_Hershko.
- Proteasome wikiPageWikiLink B_cell.
- Proteasome wikiPageWikiLink Bacteria.
- Proteasome wikiPageWikiLink Biomolecular_structure.
- Proteasome wikiPageWikiLink Bleb_(cell_biology).
- Proteasome wikiPageWikiLink Bortezomib.
- Proteasome wikiPageWikiLink C-Fos.
- Proteasome wikiPageWikiLink C-Jun_N-terminal_kinases.
- Proteasome wikiPageWikiLink C-jun.
- Proteasome wikiPageWikiLink C-terminus.
- Proteasome wikiPageWikiLink COP9_complex.
- Proteasome wikiPageWikiLink Cancer.
- Proteasome wikiPageWikiLink Caspase.
- Proteasome wikiPageWikiLink Catalysis.
- Proteasome wikiPageWikiLink Category:Apoptosis.
- Proteasome wikiPageWikiLink Category:Organelles.
- Proteasome wikiPageWikiLink Category:Protein_complexes.
- Proteasome wikiPageWikiLink Category:Proteins.
- Proteasome wikiPageWikiLink Cell_(biology).
- Proteasome wikiPageWikiLink Cell_adhesion_molecule.
- Proteasome wikiPageWikiLink Cell_culture.
- Proteasome wikiPageWikiLink Cell_cycle.
- Proteasome wikiPageWikiLink Cell_growth.
- Proteasome wikiPageWikiLink Cell_nucleus.
- Proteasome wikiPageWikiLink Cell_signaling.
- Proteasome wikiPageWikiLink Cellular_differentiation.
- Proteasome wikiPageWikiLink Chaperone_(protein).
- Proteasome wikiPageWikiLink Chemical_reaction.
- Proteasome wikiPageWikiLink Chemotherapy.
- Proteasome wikiPageWikiLink Chymotrypsin.
- Proteasome wikiPageWikiLink Concentration.
- Proteasome wikiPageWikiLink Conformational_change.
- Proteasome wikiPageWikiLink Conserved_sequence.
- Proteasome wikiPageWikiLink Covalent_bond.
- Proteasome wikiPageWikiLink Creutzfeldt–Jakob_disease.
- Proteasome wikiPageWikiLink Cyclin.
- Proteasome wikiPageWikiLink Cyclin-dependent_kinase.
- Proteasome wikiPageWikiLink Cyclin_A.
- Proteasome wikiPageWikiLink Cyclin_B.
- Proteasome wikiPageWikiLink Cysteine.
- Proteasome wikiPageWikiLink Cytokine.
- Proteasome wikiPageWikiLink Cytoplasm.
- Proteasome wikiPageWikiLink Dementia.
- Proteasome wikiPageWikiLink Disulfide.
- Proteasome wikiPageWikiLink Electron_microscope.
- Proteasome wikiPageWikiLink Endoplasmic-reticulum-associated_protein_degradation.
- Proteasome wikiPageWikiLink Enzyme.
- Proteasome wikiPageWikiLink Epstein–Barr_virus.
- Proteasome wikiPageWikiLink Eukaryote.
- Proteasome wikiPageWikiLink Eukaryotic_initiation_factor.
- Proteasome wikiPageWikiLink Evolution.
- Proteasome wikiPageWikiLink Exosome_complex.
- Proteasome wikiPageWikiLink Facilitated_diffusion.
- Proteasome wikiPageWikiLink Fibroin.
- Proteasome wikiPageWikiLink File:Hslvu_ecoli.png.
- Proteasome wikiPageWikiLink Fluorescence.
- Proteasome wikiPageWikiLink Fox_Chase_Cancer_Center.
- Proteasome wikiPageWikiLink G0_phase.