Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Prolactin> ?p ?o }
- Prolactin abstract "Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that in humans is best known for its role in enabling mammals, usually females, to produce milk; however, it is influential over a large number of functions with over 300 separate actions of PRL having been reported in various vertebrates. Prolactin is secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation, and nursing. Prolactin is secreted in a pulsatile fashion in between these events. Prolactin also plays an essential role in metabolism, regulation of the immune system, and pancreatic development.Discovered in non-human animals around 1930 by Oscar Riddle at Cold Spring Harbor Laboratory on Long Island, New York, and confirmed in humans in 1970 by Henry Friesen prolactin is a peptide hormone, encoded by the PRL gene.Although often associated with human milk production, prolactin plays a wide range of other roles in both humans and other vertebrates. (For example, in fish—the oldest known vertebrates—an important function is probably related to control of water and salt balance.) Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. It has important cell cycle related functions as a growth-, differentiating- and anti-apoptotic factor. As a growth factor, binding to cytokine like receptors, it also has profound influence on hematopoiesis, angiogenesis and is involved in the regulation of blood clotting through several pathways. The hormone acts in endocrine, autocrine, and paracrine manner through the prolactin receptor and a large number of cytokine receptors.Pituitary prolactin secretion is regulated by endocrine neurons in the hypothalamus, the most important ones being the neurosecretory tuberoinfundibulum (TIDA) neurons of the arcuate nucleus, which secrete dopamine (aka Prolactin Inhibitory Hormone) to act on the D2 receptors of lactotrophs, causing inhibition of prolactin secretion. Thyrotropin-releasing factor (thyrotropin-releasing hormone) has a stimulatory effect on prolactin release, however Prl is the only adenohypophyseal hormone whose principal control is inhibitory.Several variants and forms are known per species. Many fish have variants prolactin A and prolactin B. Most vertebrates including humans also have the closely related somatolactin. In humans, three smaller (4, 16, and 22 kDa) and several larger (so called big and big-big) variants exist.".
- Prolactin entrezgene "5617".
- Prolactin wikiPageExternalLink prolactin.html.
- Prolactin wikiPageExternalLink test.
- Prolactin wikiPageExternalLink Diagnosis-Treatment-of-Hyperprolactinemia.pdf.
- Prolactin wikiPageID "214297".
- Prolactin wikiPageLength "42600".
- Prolactin wikiPageOutDegree "169".
- Prolactin wikiPageRevisionID "702217034".
- Prolactin wikiPageWikiLink Agonist.
- Prolactin wikiPageWikiLink Amenorrhoea.
- Prolactin wikiPageWikiLink Amino_acid.
- Prolactin wikiPageWikiLink Androgen_deficiency.
- Prolactin wikiPageWikiLink Angiogenesis.
- Prolactin wikiPageWikiLink Anterior_pituitary.
- Prolactin wikiPageWikiLink Apoptosis.
- Prolactin wikiPageWikiLink Arcuate_nucleus.
- Prolactin wikiPageWikiLink Arteriogenesis.
- Prolactin wikiPageWikiLink Asthenozoospermia.
- Prolactin wikiPageWikiLink Atomic_mass_unit.
- Prolactin wikiPageWikiLink Autocrine_signalling.
- Prolactin wikiPageWikiLink Axon.
- Prolactin wikiPageWikiLink Bioassay.
- Prolactin wikiPageWikiLink Breastfeeding.
- Prolactin wikiPageWikiLink Bromocriptine.
- Prolactin wikiPageWikiLink Category:Anterior_pituitary_hormones.
- Prolactin wikiPageWikiLink Category:Breastfeeding.
- Prolactin wikiPageWikiLink Category:Human_hormones.
- Prolactin wikiPageWikiLink Category:Peptide_hormones.
- Prolactin wikiPageWikiLink Central_nervous_system.
- Prolactin wikiPageWikiLink Childbirth.
- Prolactin wikiPageWikiLink Cold_Spring_Harbor_Laboratory.
- Prolactin wikiPageWikiLink Craniopharyngioma.
- Prolactin wikiPageWikiLink Cyclic_adenosine_monophosphate.
- Prolactin wikiPageWikiLink Cytokine.
- Prolactin wikiPageWikiLink Cytokine_receptor.
- Prolactin wikiPageWikiLink Day.
- Prolactin wikiPageWikiLink Decidua.
- Prolactin wikiPageWikiLink Disulfide.
- Prolactin wikiPageWikiLink Dopamine.
- Prolactin wikiPageWikiLink Dopamine_receptor_D2.
- Prolactin wikiPageWikiLink Dopaminergic.
- Prolactin wikiPageWikiLink Endocrine_system.
- Prolactin wikiPageWikiLink Endometrium.
- Prolactin wikiPageWikiLink Epileptic_seizure.
- Prolactin wikiPageWikiLink Erectile_dysfunction.
- Prolactin wikiPageWikiLink Essex.
- Prolactin wikiPageWikiLink Estrogen.
- Prolactin wikiPageWikiLink Fetus.
- Prolactin wikiPageWikiLink Follicle-stimulating_hormone.
- Prolactin wikiPageWikiLink Freeze-drying.
- Prolactin wikiPageWikiLink Galactorrhea.
- Prolactin wikiPageWikiLink Gene.
- Prolactin wikiPageWikiLink Glycosylation.
- Prolactin wikiPageWikiLink Gonadotropin.
- Prolactin wikiPageWikiLink Gonadotropin-releasing_hormone.
- Prolactin wikiPageWikiLink Growth_hormone.
- Prolactin wikiPageWikiLink Haematopoiesis.
- Prolactin wikiPageWikiLink Henry_Friesen.
- Prolactin wikiPageWikiLink Hormone.
- Prolactin wikiPageWikiLink Human_sexual_activity.
- Prolactin wikiPageWikiLink Hyperprolactinaemia.
- Prolactin wikiPageWikiLink Hypogonadism.
- Prolactin wikiPageWikiLink Hypopituitarism.
- Prolactin wikiPageWikiLink Hypoprolactinemia.
- Prolactin wikiPageWikiLink Hypothalamic–pituitary–gonadal_axis.
- Prolactin wikiPageWikiLink Hypothalamus.
- Prolactin wikiPageWikiLink Immune_system.
- Prolactin wikiPageWikiLink Immune_tolerance.
- Prolactin wikiPageWikiLink Immunoassay.
- Prolactin wikiPageWikiLink International_unit.
- Prolactin wikiPageWikiLink JAK-STAT_signaling_pathway.
- Prolactin wikiPageWikiLink Janus_kinase_2.
- Prolactin wikiPageWikiLink Lactation.
- Prolactin wikiPageWikiLink Leydig_cell.
- Prolactin wikiPageWikiLink Libido.
- Prolactin wikiPageWikiLink Litre.
- Prolactin wikiPageWikiLink Long_Island.
- Prolactin wikiPageWikiLink Lung.
- Prolactin wikiPageWikiLink Luteinizing_hormone.
- Prolactin wikiPageWikiLink Lymphocyte.
- Prolactin wikiPageWikiLink Male_lactation.
- Prolactin wikiPageWikiLink Mammary_gland.
- Prolactin wikiPageWikiLink Mass_concentration_(chemistry).
- Prolactin wikiPageWikiLink Maternal_sensitivity.
- Prolactin wikiPageWikiLink Menstrual_cycle.
- Prolactin wikiPageWikiLink Microgram.
- Prolactin wikiPageWikiLink Mitogen-activated_protein_kinase.
- Prolactin wikiPageWikiLink Molar_concentration.
- Prolactin wikiPageWikiLink Mole_(unit).
- Prolactin wikiPageWikiLink Molecular_mass.
- Prolactin wikiPageWikiLink Myelin.
- Prolactin wikiPageWikiLink Myometrium.
- Prolactin wikiPageWikiLink Neurogenesis.
- Prolactin wikiPageWikiLink New_York.
- Prolactin wikiPageWikiLink Nipple.
- Prolactin wikiPageWikiLink Oligodendrocyte.
- Prolactin wikiPageWikiLink Oligodendrocyte_progenitor_cell.
- Prolactin wikiPageWikiLink Oligospermia.
- Prolactin wikiPageWikiLink Orders_of_magnitude_(mass).