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- Progression-free_survival abstract "Progression-free survival (PFS) is a measure of the activity of a treatment on a disease. It is the time that passes from a certain date (generally the first day of treatment, or the day in which a patient is enrolled in a clinical trial) and the date on which disease \"progresses\" or the date on which the patient dies, from any cause. PFS can only be measured in patients in which a tumor is present (a similar term that applies to patients that have been successfully operated, and are therefore free from disease, is Disease-Free Survival).Time to progression (TTP) does not count patients who die from other causes but is otherwise a close equivalent to PFS (unless there are a large number of such events). The FDA gives separate definitions and prefers PFS.PFS is widely used in oncology. Since (as already said) it only applies to patients with inoperable disease that are generally treated with drugs (chemotherapy, target therapies, etc.) it will mostly be considered in relation to drug treatment of cancer.A very important aspect is the definition of \"progression\" since this generally involves imaging techniques (plain radiograms, CT scans, MRI, PET scans, ultrasounds) or other aspects: biochemical progression may be defined on the basis of an increase in a tumor marker (such as CA125 for epithelial ovarian cancer or PSA for prostate cancer). At present any change in the radiological aspect of a lesion is defined according to RECIST criteria. But progression may also be due to the appearance of a new lesion originating from the same tumor or to the appearance of new cancer in the same organ or in a different organ.Progression-free survival is often used as an alternative to overall survival (OS): this is the most reliable endpoint in clinical studies, but it will only be available after a longer time than PFS. For this reason, especially when new drugs are tested, there is a pressure (that in some cases may be absolutely acceptable while in other cases may hide economical interests) to approve new drugs on the basis of PFS data rather than waiting for OS data.PFS is considered as a \"surrogate\" of OS: in some cancers the two elements are strictly related, but in others they are not. Several agents that may prolong PFS do not prolong OS.".
- Progression-free_survival wikiPageID "15897243".
- Progression-free_survival wikiPageLength "7135".
- Progression-free_survival wikiPageOutDegree "15".
- Progression-free_survival wikiPageRevisionID "687244331".
- Progression-free_survival wikiPageWikiLink CA-125.
- Progression-free_survival wikiPageWikiLink Category:Medical_terminology.
- Progression-free_survival wikiPageWikiLink Chemotherapy.
- Progression-free_survival wikiPageWikiLink Clinical_endpoint.
- Progression-free_survival wikiPageWikiLink Food_and_Drug_Administration.
- Progression-free_survival wikiPageWikiLink McNamara_fallacy.
- Progression-free_survival wikiPageWikiLink National_Institute_for_Health_and_Care_Excellence.
- Progression-free_survival wikiPageWikiLink Non-small-cell_lung_carcinoma.
- Progression-free_survival wikiPageWikiLink Prostate-specific_antigen.
- Progression-free_survival wikiPageWikiLink Prostate_cancer.
- Progression-free_survival wikiPageWikiLink Protein_kinase_inhibitor.
- Progression-free_survival wikiPageWikiLink Randomized_controlled_trial.
- Progression-free_survival wikiPageWikiLink Response_Evaluation_Criteria_in_Solid_Tumors.
- Progression-free_survival wikiPageWikiLink Surface_epithelial-stromal_tumor.
- Progression-free_survival wikiPageWikiLink Targeted_therapy.
- Progression-free_survival wikiPageWikiLinkText "PFS".
- Progression-free_survival wikiPageWikiLinkText "Progression Free Survival".
- Progression-free_survival wikiPageWikiLinkText "Progression-free survival".
- Progression-free_survival wikiPageWikiLinkText "progression-free survival".
- Progression-free_survival wikiPageWikiLinkText "progression-free-survival".
- Progression-free_survival wikiPageUsesTemplate Template:Citation_needed.
- Progression-free_survival wikiPageUsesTemplate Template:Disputed.
- Progression-free_survival wikiPageUsesTemplate Template:Dubious.
- Progression-free_survival wikiPageUsesTemplate Template:Reflist.
- Progression-free_survival wikiPageUsesTemplate Template:When.
- Progression-free_survival subject Category:Medical_terminology.
- Progression-free_survival hypernym Measure.
- Progression-free_survival type Software.
- Progression-free_survival comment "Progression-free survival (PFS) is a measure of the activity of a treatment on a disease. It is the time that passes from a certain date (generally the first day of treatment, or the day in which a patient is enrolled in a clinical trial) and the date on which disease \"progresses\" or the date on which the patient dies, from any cause.".
- Progression-free_survival label "Progression-free survival".
- Progression-free_survival sameAs Q2112244.
- Progression-free_survival sameAs Progressionsfreies_Überleben.
- Progression-free_survival sameAs Supervivencia_libre_de_progresión.
- Progression-free_survival sameAs Survie_sans_aggravation.
- Progression-free_survival sameAs m.03qf7mk.
- Progression-free_survival sameAs Preživetje_brez_napredovanja_bolezni.
- Progression-free_survival sameAs Q2112244.
- Progression-free_survival wasDerivedFrom Progression-free_survival?oldid=687244331.
- Progression-free_survival isPrimaryTopicOf Progression-free_survival.