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- Pridopidine abstract "Pridopidine (Huntexil, formerly ACR16) is an experimental drug candidate belonging to a class of agents known as dopidines, which act as dopaminergic stabilizers in the central nervous system. These compounds may counteract the effects of excessive or insufficient dopaminergic transmission, and are therefore under investigation for application in neurological and psychiatric disorders characterized by altered dopaminergic transmission, such as Huntington's disease (HD).Pridopidine is in late-stage development by Teva Pharmaceutical Industries who acquired the rights to the product from its original developer NeuroSearch in 2012. In April 2010, NeuroSearch announced results from the largest European phase 3 study in HD carried out to date (MermaiHD). The MermaiHD study examined the effects of pridopidine in patients with HD and the results showed after six months of treatment, pridopidine improved total motor symptoms, although the primary endpoint of the study was not met. Pridopidine was well tolerated and had an adverse event profile similar to placebo.The US Food and Drug Administration (FDA) and European Medicines Agency (EMA) have both indicated they will not issue approval for pridopidine to be used in human patients on the basis of the MermaiHD and HART trials, and a further, positive phase 3 trial is required for approval.".
- Pridopidine iupacName "4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine".
- Pridopidine thumbnail Pridopidine.svg?width=300.
- Pridopidine wikiPageID "24514575".
- Pridopidine wikiPageLength "18323".
- Pridopidine wikiPageOutDegree "36".
- Pridopidine wikiPageRevisionID "689851726".
- Pridopidine wikiPageWikiLink Adverse_event.
- Pridopidine wikiPageWikiLink Agonist.
- Pridopidine wikiPageWikiLink Akathisia.
- Pridopidine wikiPageWikiLink Arc_(protein).
- Pridopidine wikiPageWikiLink Blind_experiment.
- Pridopidine wikiPageWikiLink Category:Huntingtons_disease.
- Pridopidine wikiPageWikiLink Category:Piperidines.
- Pridopidine wikiPageWikiLink Category:Sulfones.
- Pridopidine wikiPageWikiLink Central_nervous_system.
- Pridopidine wikiPageWikiLink Cerebral_cortex.
- Pridopidine wikiPageWikiLink Chemical_affinity.
- Pridopidine wikiPageWikiLink Clinical_endpoint.
- Pridopidine wikiPageWikiLink Dissociation_(chemistry).
- Pridopidine wikiPageWikiLink Dizocilpine.
- Pridopidine wikiPageWikiLink Dopamine_receptor.
- Pridopidine wikiPageWikiLink European_Medicines_Agency.
- Pridopidine wikiPageWikiLink Extrapyramidal_symptoms.
- Pridopidine wikiPageWikiLink Food_and_Drug_Administration.
- Pridopidine wikiPageWikiLink Glutamic_acid.
- Pridopidine wikiPageWikiLink Huntingtons_disease.
- Pridopidine wikiPageWikiLink Hypokinesia.
- Pridopidine wikiPageWikiLink In_vitro.
- Pridopidine wikiPageWikiLink In_vivo.
- Pridopidine wikiPageWikiLink Intrinsic_activity.
- Pridopidine wikiPageWikiLink Ligand_(biochemistry).
- Pridopidine wikiPageWikiLink Mechanism_of_action.
- Pridopidine wikiPageWikiLink NeuroSearch.
- Pridopidine wikiPageWikiLink OSU-6162.
- Pridopidine wikiPageWikiLink Phases_of_clinical_research.
- Pridopidine wikiPageWikiLink Placebo.
- Pridopidine wikiPageWikiLink Placebo-controlled_study.
- Pridopidine wikiPageWikiLink Receptor_antagonist.
- Pridopidine wikiPageWikiLink Teva_Pharmaceutical_Industries.
- Pridopidine wikiPageWikiLinkText "MermaiHD".
- Pridopidine wikiPageWikiLinkText "Pridopidine".
- Pridopidine wikiPageWikiLinkText "dopaminergic stabilizers".
- Pridopidine wikiPageWikiLinkText "pridopidine".
- Pridopidine colwidth "30".
- Pridopidine imagefile "Pridopidine.svg".
- Pridopidine imagesize "200".
- Pridopidine iupacname "4".
- Pridopidine verifiedfields "changed".
- Pridopidine verifiedrevid "449038844".
- Pridopidine watchedfields "changed".
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- Pridopidine subject Category:Huntingtons_disease.
- Pridopidine subject Category:Piperidines.
- Pridopidine subject Category:Sulfones.
- Pridopidine hypernym Candidate.
- Pridopidine type ChemicalCompound.
- Pridopidine type ChemicalSubstance.
- Pridopidine type Group.
- Pridopidine type Person.
- Pridopidine type Chemical.
- Pridopidine type Disorder.
- Pridopidine type Group.
- Pridopidine type Heterocycle.
- Pridopidine type ChemicalObject.
- Pridopidine type Thing.
- Pridopidine type Q11173.
- Pridopidine comment "Pridopidine (Huntexil, formerly ACR16) is an experimental drug candidate belonging to a class of agents known as dopidines, which act as dopaminergic stabilizers in the central nervous system.".
- Pridopidine label "Pridopidine".
- Pridopidine sameAs Q7242858.
- Pridopidine sameAs m.0bmb571.
- Pridopidine sameAs Pridopidin.
- Pridopidine sameAs Pridopidin.
- Pridopidine sameAs Q7242858.
- Pridopidine wasDerivedFrom Pridopidine?oldid=689851726.
- Pridopidine depiction Pridopidine.svg.
- Pridopidine isPrimaryTopicOf Pridopidine.