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- Poly(amidoamine) abstract "Poly(amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality. PAMAM dendrimers, sometimes referred to by the trade name Starburst, have been extensively studied since their synthesis in 1985, and represent the most well-characterized dendrimer family as well as the first to be commercialized. Like other dendrimers, PAMAMs have a sphere-like shape overall, and are typified by an internal molecular architecture consisting of tree-like branching, with each outward 'layer', or generation, containing exponentially more branching points. This branched architecture distinguishes PAMAMs and other dendrimers from traditional polymers, as it allows for low polydispersity and a high level of structural control during synthesis, and gives rise to a large number of surface sites relative to the total molecular volume. Moreover, PAMAM dendrimers exhibit greater biocompatibility than other dendrimer families, perhaps due to the combination of surface amines and interior amide bonds; these bonding motifs are highly reminiscent of innate biological chemistry and endow PAMAM dendrimers with properties similar to that of globular proteins. The relative ease/low cost of synthesis of PAMAM dendrimers (especially relative to similarly-sized biological molecules such as proteins and antibodies), along with their biocompatibility, structural control, and functionalizability, have made PAMAMs viable candidates for application in drug development, biochemistry, and nanotechnology.".
- Poly(amidoamine) thumbnail PAMAM_Divergent_Synthesis_Color-Coded.png?width=300.
- Poly(amidoamine) wikiPageExternalLink pmidlookup?view=long&pmid=8070111.
- Poly(amidoamine) wikiPageID "41237117".
- Poly(amidoamine) wikiPageLength "40765".
- Poly(amidoamine) wikiPageOutDegree "55".
- Poly(amidoamine) wikiPageRevisionID "705272037".
- Poly(amidoamine) wikiPageWikiLink Bovine_spongiform_encephalopathy.
- Poly(amidoamine) wikiPageWikiLink Cancer_cell.
- Poly(amidoamine) wikiPageWikiLink Category:Dendrimers.
- Poly(amidoamine) wikiPageWikiLink Cell_death.
- Poly(amidoamine) wikiPageWikiLink Cell_membrane.
- Poly(amidoamine) wikiPageWikiLink Cisplatin.
- Poly(amidoamine) wikiPageWikiLink Creutzfeldt–Jakob_disease.
- Poly(amidoamine) wikiPageWikiLink Cytotoxicity.
- Poly(amidoamine) wikiPageWikiLink DAPI.
- Poly(amidoamine) wikiPageWikiLink Dendrimer.
- Poly(amidoamine) wikiPageWikiLink Dispersity.
- Poly(amidoamine) wikiPageWikiLink Drug_delivery.
- Poly(amidoamine) wikiPageWikiLink Electroporation.
- Poly(amidoamine) wikiPageWikiLink Endosome.
- Poly(amidoamine) wikiPageWikiLink File:Activation_of_PAMAM_via_hydrolysis.png.
- Poly(amidoamine) wikiPageWikiLink File:PAMAM_Convergent_Synthesis.png.
- Poly(amidoamine) wikiPageWikiLink File:PAMAM_DNA_Complexation.png.
- Poly(amidoamine) wikiPageWikiLink File:PAMAM_Divergent_Synthesis_Color-Coded.png.
- Poly(amidoamine) wikiPageWikiLink Folate_receptor.
- Poly(amidoamine) wikiPageWikiLink Functional_group.
- Poly(amidoamine) wikiPageWikiLink Gene_expression.
- Poly(amidoamine) wikiPageWikiLink Globular_protein.
- Poly(amidoamine) wikiPageWikiLink Hemolysis.
- Poly(amidoamine) wikiPageWikiLink Hydrolysis.
- Poly(amidoamine) wikiPageWikiLink Immortalised_cell_line.
- Poly(amidoamine) wikiPageWikiLink Immunogenicity.
- Poly(amidoamine) wikiPageWikiLink LDH_assay.
- Poly(amidoamine) wikiPageWikiLink Ligand.
- Poly(amidoamine) wikiPageWikiLink Lipid.
- Poly(amidoamine) wikiPageWikiLink Liposome.
- Poly(amidoamine) wikiPageWikiLink Lysis.
- Poly(amidoamine) wikiPageWikiLink MTT_assay.
- Poly(amidoamine) wikiPageWikiLink Metabolism.
- Poly(amidoamine) wikiPageWikiLink Methotrexate.
- Poly(amidoamine) wikiPageWikiLink Microinjection.
- Poly(amidoamine) wikiPageWikiLink Mitochondrion.
- Poly(amidoamine) wikiPageWikiLink Molecular_mass.
- Poly(amidoamine) wikiPageWikiLink Nanotechnology.
- Poly(amidoamine) wikiPageWikiLink Neutron_capture_therapy_of_cancer.
- Poly(amidoamine) wikiPageWikiLink Nuclease.
- Poly(amidoamine) wikiPageWikiLink Polyethylene_glycol.
- Poly(amidoamine) wikiPageWikiLink Polymer.
- Poly(amidoamine) wikiPageWikiLink Prion.
- Poly(amidoamine) wikiPageWikiLink Protecting_group.
- Poly(amidoamine) wikiPageWikiLink Protonation.
- Poly(amidoamine) wikiPageWikiLink Qiagen.
- Poly(amidoamine) wikiPageWikiLink Red_blood_cell.
- Poly(amidoamine) wikiPageWikiLink Steric_effects.
- Poly(amidoamine) wikiPageWikiLink Surface_charge.
- Poly(amidoamine) wikiPageWikiLink Transfection.
- Poly(amidoamine) wikiPageWikiLink Viral_vector.
- Poly(amidoamine) wikiPageWikiLinkText "Poly(amidoamine)".
- Poly(amidoamine) wikiPageWikiLinkText "SuperFect".
- Poly(amidoamine) wikiPageWikiLinkText "poly(amidoamine)".
- Poly(amidoamine) wikiPageUsesTemplate Template:Cite_journal.
- Poly(amidoamine) wikiPageUsesTemplate Template:Reflist.
- Poly(amidoamine) subject Category:Dendrimers.
- Poly(amidoamine) hypernym Dendrimer.
- Poly(amidoamine) comment "Poly(amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality. PAMAM dendrimers, sometimes referred to by the trade name Starburst, have been extensively studied since their synthesis in 1985, and represent the most well-characterized dendrimer family as well as the first to be commercialized.".
- Poly(amidoamine) label "Poly(amidoamine)".
- Poly(amidoamine) sameAs Q17165702.
- Poly(amidoamine) sameAs m.0zgb0d5.
- Poly(amidoamine) sameAs Q17165702.
- Poly(amidoamine) wasDerivedFrom Poly(amidoamine)?oldid=705272037.
- Poly(amidoamine) depiction PAMAM_Divergent_Synthesis_Color-Coded.png.
- Poly(amidoamine) isPrimaryTopicOf Poly(amidoamine).