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- Phosphorylase_kinase abstract "Phosphorylase kinase (PhK) is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen. PhK phosphorylates glycogen phosphorylase at two serine residues, triggering a conformational shift which favors the more active glycogen phosphorylase “a” form over the less active glycogen phosphorylase b.The protein is a hexadecameric holoenzyme--that is, a homotetramer in which each subunit is itself a tetramer--arranged in an approximate “butterfly” shape. Each of the subunits is composed of an α, β, γ and δ subunit. The γ subunit is the site of the enzyme's catalytic activity while the other three subunits serve regulatory functions.When unmodified, the α and β subunits inhibit the enzyme's catalysis, but phosphorylation of both these subunits by protein kinase A (PKA, or cAMP-dependent protein kinase) reduces their respective inhibitory activities. The δ subunit is the ubiquitous eukaryotic protein calmodulin which itself has 4 calcium ion binding sites. When cytosolic Ca2+ levels rise-to as low as 10−7 M—the δ subunit undergoes a large conformational change that activates the kinase's activity by binding to a complementary hydrophobic patch on the catalytic γ subunit.".
- Phosphorylase_kinase ecNumber "2.7.11.19".
- Phosphorylase_kinase thumbnail PhK_1QL6_gamma_small.png?width=300.
- Phosphorylase_kinase wikiPageExternalLink johnson_02.html.
- Phosphorylase_kinase wikiPageID "7202281".
- Phosphorylase_kinase wikiPageLength "17827".
- Phosphorylase_kinase wikiPageOutDegree "38".
- Phosphorylase_kinase wikiPageRevisionID "699091126".
- Phosphorylase_kinase wikiPageWikiLink Active_site.
- Phosphorylase_kinase wikiPageWikiLink Adenosine_triphosphate.
- Phosphorylase_kinase wikiPageWikiLink Adrenergic_receptor.
- Phosphorylase_kinase wikiPageWikiLink Allosteric_regulation.
- Phosphorylase_kinase wikiPageWikiLink Calmodulin.
- Phosphorylase_kinase wikiPageWikiLink Category:EC_2.7.11.
- Phosphorylase_kinase wikiPageWikiLink Category:Protein_kinases.
- Phosphorylase_kinase wikiPageWikiLink Cyclic_adenosine_monophosphate.
- Phosphorylase_kinase wikiPageWikiLink Endoplasmic_reticulum.
- Phosphorylase_kinase wikiPageWikiLink Enzyme.
- Phosphorylase_kinase wikiPageWikiLink Epinephrine.
- Phosphorylase_kinase wikiPageWikiLink Gene_duplication.
- Phosphorylase_kinase wikiPageWikiLink Glucose.
- Phosphorylase_kinase wikiPageWikiLink Glucose_1-phosphate.
- Phosphorylase_kinase wikiPageWikiLink Glycogen.
- Phosphorylase_kinase wikiPageWikiLink Glycogen_phosphorylase.
- Phosphorylase_kinase wikiPageWikiLink Glycogen_storage_disease.
- Phosphorylase_kinase wikiPageWikiLink Glycogenolysis.
- Phosphorylase_kinase wikiPageWikiLink Hydrophobe.
- Phosphorylase_kinase wikiPageWikiLink Missense_mutation.
- Phosphorylase_kinase wikiPageWikiLink Nonsense_mutation.
- Phosphorylase_kinase wikiPageWikiLink PHKA2.
- Phosphorylase_kinase wikiPageWikiLink PHKB.
- Phosphorylase_kinase wikiPageWikiLink PHKG1.
- Phosphorylase_kinase wikiPageWikiLink PHKG2.
- Phosphorylase_kinase wikiPageWikiLink Phosphatase.
- Phosphorylase_kinase wikiPageWikiLink Phosphate.
- Phosphorylase_kinase wikiPageWikiLink Phosphorylase_kinase,_alpha_1.
- Phosphorylase_kinase wikiPageWikiLink Phosphorylation.
- Phosphorylase_kinase wikiPageWikiLink Protein_kinase_A.
- Phosphorylase_kinase wikiPageWikiLink Serine.
- Phosphorylase_kinase wikiPageWikiLink threonine-specific_protein_kinase.
- Phosphorylase_kinase wikiPageWikiLink Signal_transduction.
- Phosphorylase_kinase wikiPageWikiLink Α-adrenergic.
- Phosphorylase_kinase wikiPageWikiLink File:PhK_diagram.png.
- Phosphorylase_kinase wikiPageWikiLinkText "Phosphorylase kinase".
- Phosphorylase_kinase wikiPageWikiLinkText "phosphorylase b kinase".
- Phosphorylase_kinase wikiPageWikiLinkText "phosphorylase kinase".
- Phosphorylase_kinase caption "Catalytic subunit of phosphorylase kinase".
- Phosphorylase_kinase casNumber "9001".
- Phosphorylase_kinase ecNumber "2.7".
- Phosphorylase_kinase iubmbEcNumber "2".
- Phosphorylase_kinase name "Phosphorylase kinase".
- Phosphorylase_kinase width "250".
- Phosphorylase_kinase wikiPageUsesTemplate Template:EC_number.
- Phosphorylase_kinase wikiPageUsesTemplate Template:Enzymes.
- Phosphorylase_kinase wikiPageUsesTemplate Template:Glycogenesis_and_glycogenolysis.
- Phosphorylase_kinase wikiPageUsesTemplate Template:Infobox_enzyme.
- Phosphorylase_kinase wikiPageUsesTemplate Template:MeshName.
- Phosphorylase_kinase wikiPageUsesTemplate Template:Portal_bar.
- Phosphorylase_kinase wikiPageUsesTemplate Template:Reflist.
- Phosphorylase_kinase wikiPageUsesTemplate threonine-specific_protein_kinases.
- Phosphorylase_kinase subject Category:EC_2.7.11.
- Phosphorylase_kinase subject Category:Protein_kinases.
- Phosphorylase_kinase hypernym Kinase.
- Phosphorylase_kinase type Biomolecule.
- Phosphorylase_kinase type Enzyme.
- Phosphorylase_kinase type Protein.
- Phosphorylase_kinase type Thing.
- Phosphorylase_kinase type Q206229.
- Phosphorylase_kinase type Q8047.
- Phosphorylase_kinase comment "Phosphorylase kinase (PhK) is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen.".
- Phosphorylase_kinase label "Phosphorylase kinase".
- Phosphorylase_kinase sameAs Q906540.
- Phosphorylase_kinase sameAs Phosphorylase-Kinase.
- Phosphorylase_kinase sameAs Fosforilasa_kinasa.
- Phosphorylase_kinase sameAs Fosforylaasikinaasi.
- Phosphorylase_kinase sameAs m.025vzqc.
- Phosphorylase_kinase sameAs Fosforilaza_kinaza.
- Phosphorylase_kinase sameAs Fosforilaza_kinaza.
- Phosphorylase_kinase sameAs Q906540.
- Phosphorylase_kinase sameAs 磷酸化酶激酶.
- Phosphorylase_kinase wasDerivedFrom Phosphorylase_kinase?oldid=699091126.
- Phosphorylase_kinase depiction PhK_1QL6_gamma_small.png.
- Phosphorylase_kinase isPrimaryTopicOf Phosphorylase_kinase.
- Phosphorylase_kinase name "Phosphorylase kinase".