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- Phosphatidylinositol_5-phosphate abstract "Phosphatidylinositol 5-phosphate (PtdIns5P) is a phosphoinositide, one of the phosphorylated derivatives of phosphatidylinositol (PtdIns), that are well-established membrane-anchored regulatory molecules. Phosphoinositides participate in signaling events that control cytoskeletal dynamics, intracellular membrane trafficking, cell proliferation and many other cellular functions. Generally, phosphoinositides transduce signals by recruiting specific phosphoinositide-binding proteins to intracellular membranes.Phosphatidylinositol 5-phosphate is one of the 7 known cellular phosphoinositides with less understood functions. It is phosphorylated on position D-5 of the inositol head group, which is attached via phosphodiester linkage to diacylglycerol (with varying chemical composition of the acyl chains, frequently 1-stearoyl-2-arachidonoyl chain). In quiescent cells, on average, PtdIns5P is of similar or higher abundance as compared to PtdIns3P and ~20-100-fold below the levels of PtdIns4P (Phosphatidylinositol 4-phosphate and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate).Notably, steady-state PtdIns5P levels are more than 5-fold higher than those of PtdIns(3,5)P2.PtdIns5P was first demonstrated by HPLC (high pressure liquid chromatography) in mouse fibroblasts as a substrate for PtdIns(4,5)P2 synthesis by type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase). In many cell types, however, PtdIns5P is not detected by HPLC due to technical limitations associated with its poor separation from the abundant PtdIns4P. Rather, PtdIns5P is measured by the \"mass assay\", where PtdIns5P (as a part of the extracted cellular lipids) is converted in vitro by purified PtdIns5P 4-kinase to PtdIns(4,5)P2 that is subsequently quantified.Based on studies with the mass assay and an improved HPLC technique, PtdIns5P is detected in all studied mammalian cells. Most of the cellular PtdIns5P is found on cytoplasmic membranes whereas a smaller fraction resides in the nucleus. The cytoplasmic and nuclear pools have distinct functions and regulation.".
- Phosphatidylinositol_5-phosphate wikiPageID "22914364".
- Phosphatidylinositol_5-phosphate wikiPageLength "14450".
- Phosphatidylinositol_5-phosphate wikiPageOutDegree "21".
- Phosphatidylinositol_5-phosphate wikiPageRevisionID "689840340".
- Phosphatidylinositol_5-phosphate wikiPageWikiLink 1-phosphatidylinositol-5-phosphate_4-kinase.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Acetylation.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Apoptosis.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Category:Cell_signaling.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Category:Phospholipids.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink DOK1.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink DOK2.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Fig4.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink High-performance_liquid_chromatography.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Histone.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink ING2.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink MTMR2.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Myotubularin_1.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink P53.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink PIKFYVE.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Phosphatidylinositol_3,5-bisphosphate.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Phosphatidylinositol_3-phosphate.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Phosphatidylinositol_4,5-bisphosphate.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Phosphatidylinositol_4-phosphate.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink Shigella_flexneri.
- Phosphatidylinositol_5-phosphate wikiPageWikiLink VAC14.
- Phosphatidylinositol_5-phosphate wikiPageWikiLinkText "PI(5)P".
- Phosphatidylinositol_5-phosphate wikiPageWikiLinkText "Phosphatidylinositol 5-phosphate".
- Phosphatidylinositol_5-phosphate wikiPageWikiLinkText "PtdIns(5)P".
- Phosphatidylinositol_5-phosphate wikiPageWikiLinkText "phosphatidylinositol 5-phosphate".
- Phosphatidylinositol_5-phosphate wikiPageUsesTemplate Template:Phospholipids.
- Phosphatidylinositol_5-phosphate wikiPageUsesTemplate Template:Reflist.
- Phosphatidylinositol_5-phosphate subject Category:Cell_signaling.
- Phosphatidylinositol_5-phosphate subject Category:Phospholipids.
- Phosphatidylinositol_5-phosphate hypernym Phosphoinositide.
- Phosphatidylinositol_5-phosphate type Lipid.
- Phosphatidylinositol_5-phosphate type Lipid.
- Phosphatidylinositol_5-phosphate type Organophosphate.
- Phosphatidylinositol_5-phosphate type Organophosphate.
- Phosphatidylinositol_5-phosphate comment "Phosphatidylinositol 5-phosphate (PtdIns5P) is a phosphoinositide, one of the phosphorylated derivatives of phosphatidylinositol (PtdIns), that are well-established membrane-anchored regulatory molecules. Phosphoinositides participate in signaling events that control cytoskeletal dynamics, intracellular membrane trafficking, cell proliferation and many other cellular functions.".
- Phosphatidylinositol_5-phosphate label "Phosphatidylinositol 5-phosphate".
- Phosphatidylinositol_5-phosphate sameAs Q3381501.
- Phosphatidylinositol_5-phosphate sameAs Phosphatidylinositol-5-phosphate.
- Phosphatidylinositol_5-phosphate sameAs Fosfatidilinositol_5-fosfato.
- Phosphatidylinositol_5-phosphate sameAs m.063zvwt.
- Phosphatidylinositol_5-phosphate sameAs Fosfatidilinozitol_5-fosfat.
- Phosphatidylinositol_5-phosphate sameAs Fosfatidilinozitol_5-fosfat.
- Phosphatidylinositol_5-phosphate sameAs Q3381501.
- Phosphatidylinositol_5-phosphate wasDerivedFrom Phosphatidylinositol_5-phosphate?oldid=689840340.
- Phosphatidylinositol_5-phosphate isPrimaryTopicOf Phosphatidylinositol_5-phosphate.