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- Pexacerfont abstract "Pexacerfont (BMS-562,086) is a drug developed by Bristol-Myers Squibb which acts as a CRF-1 antagonist. Corticotropin releasing factor (CRF), also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress. This then triggers the release of corticotropin (ACTH), another hormone which is involved in the physiological response to stress. Chronic release of CRF and ACTH is believed to be directly or indirectly involved in many of the harmful physiological effects of chronic stress, such as excessive glucocorticoid release, diabetes mellitus, osteoporosis, stomach ulcers, anxiety, depression, and development of high blood pressure and consequent cardiovascular problems.Pexacerfont is a recently developed CRF-1 antagonist which is currently in clinical trials for the treatment of anxiety disorders, and has also been proposed to be useful for the treatment of depression and irritable bowel syndrome.A recent multicenter, randomized, double-blind, placebo-controlled trial found that Pexacerfont (100 mg/day) did not separate from placebo on the primary outcome measure (the mean change from baseline to end point in the Hamilton Anxiety Scale score). These results suggest that blockade of CRF-1 receptor may not be a feasible treatment for anxiety disorders in certain human populations.".
- Pexacerfont atcPrefix "none".
- Pexacerfont casNumber "459856-18-9".
- Pexacerfont fdaUniiCode "LF1VBG4ZUK".
- Pexacerfont iupacName "8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine".
- Pexacerfont pubchem "9884366".
- Pexacerfont thumbnail Pexacerfont.svg?width=300.
- Pexacerfont wikiPageID "15817090".
- Pexacerfont wikiPageLength "4096".
- Pexacerfont wikiPageOutDegree "21".
- Pexacerfont wikiPageRevisionID "608392119".
- Pexacerfont wikiPageWikiLink Adrenocorticotropic_hormone.
- Pexacerfont wikiPageWikiLink Antalarmin.
- Pexacerfont wikiPageWikiLink Anxiety.
- Pexacerfont wikiPageWikiLink Bristol-Myers_Squibb.
- Pexacerfont wikiPageWikiLink CP-154,526.
- Pexacerfont wikiPageWikiLink Category:Anxiolytics.
- Pexacerfont wikiPageWikiLink Category:Bristol-Myers_Squibb.
- Pexacerfont wikiPageWikiLink Category:CRF-1_antagonists.
- Pexacerfont wikiPageWikiLink Category:Corticotropin-releasing_hormone.
- Pexacerfont wikiPageWikiLink Category:Phenol_ethers.
- Pexacerfont wikiPageWikiLink Category:Pyridines.
- Pexacerfont wikiPageWikiLink Corticotropin-releasing_hormone.
- Pexacerfont wikiPageWikiLink Corticotropin-releasing_hormone_antagonist.
- Pexacerfont wikiPageWikiLink Corticotropin-releasing_hormone_receptor_1.
- Pexacerfont wikiPageWikiLink Depression_(mood).
- Pexacerfont wikiPageWikiLink Diabetes_mellitus.
- Pexacerfont wikiPageWikiLink Glucocorticoid.
- Pexacerfont wikiPageWikiLink Hamilton_Anxiety_Rating_Scale.
- Pexacerfont wikiPageWikiLink Hypertension.
- Pexacerfont wikiPageWikiLink Osteoporosis.
- Pexacerfont wikiPageWikiLink Peptic_ulcer.
- Pexacerfont wikiPageWikiLinkText "Pexacerfont".
- Pexacerfont wikiPageWikiLinkText "pexacerfont".
- Pexacerfont atcPrefix "none".
- Pexacerfont c "18".
- Pexacerfont casNumber "459856".
- Pexacerfont chemspiderid "8060040".
- Pexacerfont h "24".
- Pexacerfont inchi "1".
- Pexacerfont inchikey "LBWQSAZEYIZZCE-SNVBAGLBBW".
- Pexacerfont iupacName "8".
- Pexacerfont kegg "D10022".
- Pexacerfont legalStatus "Uncontrolled".
- Pexacerfont molecularWeight "340.4".
- Pexacerfont n "6".
- Pexacerfont o "1".
- Pexacerfont pubchem "9884366".
- Pexacerfont routesOfAdministration "Oral".
- Pexacerfont smiles "CC[C@@H]NC1=NCC".
- Pexacerfont stdinchi "1".
- Pexacerfont stdinchikey "LBWQSAZEYIZZCE-SNVBAGLBSA-N".
- Pexacerfont unii "LF1VBG4ZUK".
- Pexacerfont verifiedrevid "437186450".
- Pexacerfont wikiPageUsesTemplate Template:Antidepressants.
- Pexacerfont wikiPageUsesTemplate Template:Anxiolytics.
- Pexacerfont wikiPageUsesTemplate Template:Drugbox.
- Pexacerfont wikiPageUsesTemplate Template:Fdacite.
- Pexacerfont wikiPageUsesTemplate Template:Keggcite.
- Pexacerfont wikiPageUsesTemplate Template:Neuropeptidergics.
- Pexacerfont wikiPageUsesTemplate Template:Reflist.
- Pexacerfont subject Category:Anxiolytics.
- Pexacerfont subject Category:Bristol-Myers_Squibb.
- Pexacerfont subject Category:CRF-1_antagonists.
- Pexacerfont subject Category:Corticotropin-releasing_hormone.
- Pexacerfont subject Category:Phenol_ethers.
- Pexacerfont subject Category:Pyridines.
- Pexacerfont hypernym Drug.
- Pexacerfont type ChemicalSubstance.
- Pexacerfont type Company.
- Pexacerfont type Drug.
- Pexacerfont type Antagonist.
- Pexacerfont type Chemical.
- Pexacerfont type Company.
- Pexacerfont type Drug.
- Pexacerfont type Ether.
- Pexacerfont type Heterocycle.
- Pexacerfont type Neuropeptide.
- Pexacerfont type ChemicalObject.
- Pexacerfont type Thing.
- Pexacerfont type Q8386.
- Pexacerfont comment "Pexacerfont (BMS-562,086) is a drug developed by Bristol-Myers Squibb which acts as a CRF-1 antagonist. Corticotropin releasing factor (CRF), also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress. This then triggers the release of corticotropin (ACTH), another hormone which is involved in the physiological response to stress.".
- Pexacerfont label "Pexacerfont".
- Pexacerfont sameAs Q7179563.
- Pexacerfont sameAs m.03nwqy0.
- Pexacerfont sameAs Peksacerfont.
- Pexacerfont sameAs Peksacerfont.
- Pexacerfont sameAs Q7179563.
- Pexacerfont wasDerivedFrom Pexacerfont?oldid=608392119.
- Pexacerfont depiction Pexacerfont.svg.
- Pexacerfont isPrimaryTopicOf Pexacerfont.