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- Pasireotide abstract "Pasireotide (SOM230, trade name Signifor) is an orphan drug approved in the U.S. and Europe for the treatment of Cushing's disease and Acromegaly in patients who fail or are ineligible for surgical therapy. It was developed by Novartis. Pasireotide is a somatostatin analog which has a 40-fold increased affinity to somatostatin receptor 5 than other somatostatin analogs.The drug showed therapeutical potential in a recent study (PASPORT-CUSHINGS B2305) where 162 patients were treated with either 2x 600 µg or 2x 900 µg pasireotide s.c. daily. The effectiveness of the treatment was checked by the UFC-value (urinary free cortisol) after six months of treatment. The mean reduction of UFC after six months was 47.9%, which also lead to amelioration of clinical symptoms such as blood pressure, cholesterol value, and weight loss.Pasireotide was approved by the EMEA in October 2009 and by the FDA in December 2012.Pasireotide LAR was approved by the FDA for treatment of Acromegaly in December 2014. It had been approved by the EMEA a month earlier for the same use. For Acromegaly patients, it is viewed as a more effective alternative to Octreotide, which was coming off patent.".
- Pasireotide atcPrefix "H01".
- Pasireotide atcSuffix "CB05".
- Pasireotide casNumber "396091-73-9".
- Pasireotide chEBI "72312".
- Pasireotide drugbank "DB06663".
- Pasireotide fdaUniiCode "98H1T17066".
- Pasireotide iupacName "[(3S,6S,9S,12R,15S,18S,20R)-9-(4-aminobutyl)-3-benzyl-12-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-phenyl-6-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] N-(2-aminoethyl)carbamate".
- Pasireotide pubchem "9941444".
- Pasireotide thumbnail Pasireotide.svg?width=300.
- Pasireotide wikiPageID "31715666".
- Pasireotide wikiPageLength "5916".
- Pasireotide wikiPageOutDegree "12".
- Pasireotide wikiPageRevisionID "705655615".
- Pasireotide wikiPageWikiLink Acromegaly.
- Pasireotide wikiPageWikiLink Category:Hormonal_agents.
- Pasireotide wikiPageWikiLink Category:Orphan_drugs.
- Pasireotide wikiPageWikiLink Category:Peptides.
- Pasireotide wikiPageWikiLink Cushings_disease.
- Pasireotide wikiPageWikiLink Novartis.
- Pasireotide wikiPageWikiLink Octreotide.
- Pasireotide wikiPageWikiLink Orphan_drug.
- Pasireotide wikiPageWikiLink Somatostatin.
- Pasireotide wikiPageWikiLink Somatostatin_receptor_5.
- Pasireotide wikiPageWikiLink Structural_analog.
- Pasireotide wikiPageWikiLink Subcutaneous_injection.
- Pasireotide wikiPageWikiLinkText "Pasireotide".
- Pasireotide wikiPageWikiLinkText "pasireotide".
- Pasireotide atcPrefix "H01".
- Pasireotide atcSuffix "CB05".
- Pasireotide c "58".
- Pasireotide casNumber "396091".
- Pasireotide chebi "72312".
- Pasireotide chemspiderid "8117062".
- Pasireotide drugbank "DB06663".
- Pasireotide h "66".
- Pasireotide iupacName "[-9--3-benzyl-12--2,5,8,11,14,17-hexaoxo-15-phenyl-6-[methyl]-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] N-carbamate".
- Pasireotide iupharLigand "2018".
- Pasireotide kegg "D10147".
- Pasireotide legalStatus "Rx-only".
- Pasireotide licenceEu "Signifor".
- Pasireotide molecularWeight "1047.21".
- Pasireotide n "10".
- Pasireotide o "9".
- Pasireotide pubchem "9941444".
- Pasireotide routesOfAdministration "Subcutaneous".
- Pasireotide smiles "C1[C@H]OCNCCN".
- Pasireotide stdinchi "1".
- Pasireotide stdinchikey "VMZMNAABQBOLAK-DBILLSOUSA-N".
- Pasireotide synonyms "SOM230".
- Pasireotide tradename "Signifor".
- Pasireotide unii "98".
- Pasireotide verifiedfields "changed".
- Pasireotide verifiedrevid "451604097".
- Pasireotide watchedfields "changed".
- Pasireotide wikiPageUsesTemplate Template:Cascite.
- Pasireotide wikiPageUsesTemplate Template:Drugbankcite.
- Pasireotide wikiPageUsesTemplate Template:Drugbox.
- Pasireotide wikiPageUsesTemplate Template:Ebicite.
- Pasireotide wikiPageUsesTemplate Template:Fdacite.
- Pasireotide wikiPageUsesTemplate Template:Keggcite.
- Pasireotide wikiPageUsesTemplate Template:Peptidergics.
- Pasireotide wikiPageUsesTemplate Template:Reflist.
- Pasireotide wikiPageUsesTemplate Template:Systemic-hormonal-drug-stub.
- Pasireotide subject Category:Hormonal_agents.
- Pasireotide subject Category:Orphan_drugs.
- Pasireotide subject Category:Peptides.
- Pasireotide hypernym Drug.
- Pasireotide type Agent.
- Pasireotide type ChemicalSubstance.
- Pasireotide type Drug.
- Pasireotide type Agent.
- Pasireotide type Chemical.
- Pasireotide type Drug.
- Pasireotide type Preparation.
- Pasireotide type Redirect.
- Pasireotide type ChemicalObject.
- Pasireotide type Thing.
- Pasireotide type Q8386.
- Pasireotide comment "Pasireotide (SOM230, trade name Signifor) is an orphan drug approved in the U.S. and Europe for the treatment of Cushing's disease and Acromegaly in patients who fail or are ineligible for surgical therapy. It was developed by Novartis.".
- Pasireotide label "Pasireotide".
- Pasireotide sameAs Q3896970.
- Pasireotide sameAs Pasiréotide.
- Pasireotide sameAs Pasireotide.
- Pasireotide sameAs Pasireotide.
- Pasireotide sameAs m.0gmcrbc.
- Pasireotide sameAs Pasireotid.
- Pasireotide sameAs Pasireotid.
- Pasireotide sameAs Pasireotid.
- Pasireotide sameAs Q3896970.
- Pasireotide wasDerivedFrom Pasireotide?oldid=705655615.
- Pasireotide depiction Pasireotide.svg.
- Pasireotide isPrimaryTopicOf Pasireotide.