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- ParDE_type_II_toxin-antitoxin_system abstract "The parDE type II toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin). These systems preferentially guarantee growth of plasmid-carrying daughter cells in a bacterial population by killing newborn bacteria that have not inherited a plasmid copy at cell division (post-segregational killing).ParD is a plasmid anti-toxin that forms a ribbon-helix-helix DNA binding structure. It stabilises plasmids by inhibiting ParE toxicity in cells that express ParD and ParE. ParD forms a dimer and also regulates its own promoter (parDE). As with CcdB the toxin target is DNA gyrase. Induction of ParE toxin results in inhibition of cell division but not cell growth.The parD and ccD systems are found to be strikingly similar in terms of their structures and actions. The antitoxin protein of each system interacts with its cognate toxin to neutralise the activity of the toxin and in the process the complex of the two becomes an efficient transcription repressor.".
- ParDE_type_II_toxin-antitoxin_system symbol "ParD".
- ParDE_type_II_toxin-antitoxin_system symbol "ParE_toxin".
- ParDE_type_II_toxin-antitoxin_system thumbnail PDB_1wmi_EBI.jpg?width=300.
- ParDE_type_II_toxin-antitoxin_system wikiPageExternalLink index.php.
- ParDE_type_II_toxin-antitoxin_system wikiPageID "37411479".
- ParDE_type_II_toxin-antitoxin_system wikiPageLength "3936".
- ParDE_type_II_toxin-antitoxin_system wikiPageOutDegree "19".
- ParDE_type_II_toxin-antitoxin_system wikiPageRevisionID "679006992".
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Bacteria.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Biomolecular_structure.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Category:Protein_domains.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink CcdB_Type_II_Toxin-antitoxin_system.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Cell_(biology).
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Cell_growth.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink DNA_gyrase.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Molecular_binding.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Plasmid.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Promoter_(genetics).
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Protein.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Protein_dimer.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Repressor.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Toxicity.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Toxin-antitoxin_system.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLink Transcriptional_regulation.
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLinkText "ParD".
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLinkText "ParE".
- ParDE_type_II_toxin-antitoxin_system wikiPageWikiLinkText "parD/parE".
- ParDE_type_II_toxin-antitoxin_system caption "crystal structure of archaeal rele-relb complex from pyrococcus horikoshii ot3".
- ParDE_type_II_toxin-antitoxin_system interpro "IPR007712".
- ParDE_type_II_toxin-antitoxin_system interpro "IPR018985".
- ParDE_type_II_toxin-antitoxin_system name "ParD".
- ParDE_type_II_toxin-antitoxin_system name "ParE toxin of type II Toxin-anittoxin system".
- ParDE_type_II_toxin-antitoxin_system pfam "PF05016".
- ParDE_type_II_toxin-antitoxin_system pfam "PF09386".
- ParDE_type_II_toxin-antitoxin_system pfamClan "CL0057".
- ParDE_type_II_toxin-antitoxin_system pfamClan "CL0136".
- ParDE_type_II_toxin-antitoxin_system symbol "ParD".
- ParDE_type_II_toxin-antitoxin_system symbol "ParE_toxin".
- ParDE_type_II_toxin-antitoxin_system wikiPageUsesTemplate Template:Infobox_protein_family.
- ParDE_type_II_toxin-antitoxin_system wikiPageUsesTemplate Template:InterPro_content.
- ParDE_type_II_toxin-antitoxin_system wikiPageUsesTemplate Template:Reflist.
- ParDE_type_II_toxin-antitoxin_system subject Category:Protein_domains.
- ParDE_type_II_toxin-antitoxin_system hypernym Example.
- ParDE_type_II_toxin-antitoxin_system type Biomolecule.
- ParDE_type_II_toxin-antitoxin_system type Building.
- ParDE_type_II_toxin-antitoxin_system type Protein.
- ParDE_type_II_toxin-antitoxin_system type Chemical.
- ParDE_type_II_toxin-antitoxin_system type Domain.
- ParDE_type_II_toxin-antitoxin_system type Thing.
- ParDE_type_II_toxin-antitoxin_system type Q206229.
- ParDE_type_II_toxin-antitoxin_system type Q8054.
- ParDE_type_II_toxin-antitoxin_system comment "The parDE type II toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin).".
- ParDE_type_II_toxin-antitoxin_system label "ParDE type II toxin-antitoxin system".
- ParDE_type_II_toxin-antitoxin_system sameAs Q7133581.
- ParDE_type_II_toxin-antitoxin_system sameAs m.0nb7yd4.
- ParDE_type_II_toxin-antitoxin_system sameAs Q7133581.
- ParDE_type_II_toxin-antitoxin_system wasDerivedFrom ParDE_type_II_toxin-antitoxin_system?oldid=679006992.
- ParDE_type_II_toxin-antitoxin_system depiction PDB_1wmi_EBI.jpg.
- ParDE_type_II_toxin-antitoxin_system isPrimaryTopicOf ParDE_type_II_toxin-antitoxin_system.