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- Paclitaxel_total_synthesis abstract "Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew (Taxus brevifolia). Not only is the synthetic reproduction of the compound itself of great commercial and scientific importance, but it also opens the way to paclitaxel derivatives not found in nature but with greater potential. The paclitaxel molecule consists of a tetracyclic core called baccatin III and an amide tail. The core rings are conveniently called (from left to right) ring A (a cyclohexene), ring B (a cyclooctane), ring C (a cyclohexane) and ring D (an oxetane).The paclitaxel drug development process took over 40 years. The anti-tumor activity of a bark extract of the Pacific yew tree was discovered in 1963 as a follow up of a US government plant screening program already in existence 20 years before that. The active substance responsible for the anti-tumor activity was discovered in 1969 and structure elucidation was completed in 1971. Robert A. Holton of Florida State University succeeded in the total synthesis of paclitaxel in 1994, a project that he had started in 1982. In 1989 Holton had also developed a semisynthetic route to paclitaxel starting from 10-deacetylbaccatin III. This compound is a biosynthetic precursor and is found in larger quantities than paclitaxel itself in Taxus baccata (the European Yew). In 1990Bristol-Myers Squibb bought a licence to the patent for this process which in the years to follow earned Florida State University and Holton (with a 40% take) over 200 million US dollars.".
- Paclitaxel_total_synthesis thumbnail TaxolGeneralStructure.svg?width=300.
- Paclitaxel_total_synthesis wikiPageExternalLink 8137taxol.html.
- Paclitaxel_total_synthesis wikiPageExternalLink taxol_en.html.
- Paclitaxel_total_synthesis wikiPageExternalLink taxol.html.
- Paclitaxel_total_synthesis wikiPageExternalLink taxol.
- Paclitaxel_total_synthesis wikiPageExternalLink www.taxolog.com.
- Paclitaxel_total_synthesis wikiPageID "3901316".
- Paclitaxel_total_synthesis wikiPageLength "12315".
- Paclitaxel_total_synthesis wikiPageOutDegree "76".
- Paclitaxel_total_synthesis wikiPageRevisionID "696856316".
- Paclitaxel_total_synthesis wikiPageWikiLink 10-Deacetylbaccatin.
- Paclitaxel_total_synthesis wikiPageWikiLink Amide.
- Paclitaxel_total_synthesis wikiPageWikiLink Amine.
- Paclitaxel_total_synthesis wikiPageWikiLink Baccatin_III.
- Paclitaxel_total_synthesis wikiPageWikiLink Bristol-Myers_Squibb.
- Paclitaxel_total_synthesis wikiPageWikiLink Canada.
- Paclitaxel_total_synthesis wikiPageWikiLink Cancer.
- Paclitaxel_total_synthesis wikiPageWikiLink Category:Taxanes.
- Paclitaxel_total_synthesis wikiPageWikiLink Category:Total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Chemical_&_Engineering_News.
- Paclitaxel_total_synthesis wikiPageWikiLink China.
- Paclitaxel_total_synthesis wikiPageWikiLink Convergent_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Cyclohexane.
- Paclitaxel_total_synthesis wikiPageWikiLink Cyclohexene.
- Paclitaxel_total_synthesis wikiPageWikiLink Cyclooctane.
- Paclitaxel_total_synthesis wikiPageWikiLink Cytochrome_P450.
- Paclitaxel_total_synthesis wikiPageWikiLink Danishefsky_Taxol_total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Diterpene.
- Paclitaxel_total_synthesis wikiPageWikiLink Drug.
- Paclitaxel_total_synthesis wikiPageWikiLink Escherichia_coli.
- Paclitaxel_total_synthesis wikiPageWikiLink Florida_State_University.
- Paclitaxel_total_synthesis wikiPageWikiLink Geraniol.
- Paclitaxel_total_synthesis wikiPageWikiLink Holton_Taxol_total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Imine.
- Paclitaxel_total_synthesis wikiPageWikiLink Kuwajima_Taxol_total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Mexico.
- Paclitaxel_total_synthesis wikiPageWikiLink Michigan.
- Paclitaxel_total_synthesis wikiPageWikiLink Mucic_acid.
- Paclitaxel_total_synthesis wikiPageWikiLink Mukaiyama_Taxol_total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Nakada_Taxol_total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Nicolaou_Taxol_total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Ojima_lactam.
- Paclitaxel_total_synthesis wikiPageWikiLink Organic_chemistry.
- Paclitaxel_total_synthesis wikiPageWikiLink Oxetane.
- Paclitaxel_total_synthesis wikiPageWikiLink Paclitaxel.
- Paclitaxel_total_synthesis wikiPageWikiLink Patchoulol.
- Paclitaxel_total_synthesis wikiPageWikiLink Pentyl.
- Paclitaxel_total_synthesis wikiPageWikiLink Phenyl_group.
- Paclitaxel_total_synthesis wikiPageWikiLink Pinene.
- Paclitaxel_total_synthesis wikiPageWikiLink Propyl.
- Paclitaxel_total_synthesis wikiPageWikiLink Pyrophosphate.
- Paclitaxel_total_synthesis wikiPageWikiLink Robert_A._Holton.
- Paclitaxel_total_synthesis wikiPageWikiLink Sato-Chida_Taxol_total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Schwartzs_reagent.
- Paclitaxel_total_synthesis wikiPageWikiLink Semisynthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Serine.
- Paclitaxel_total_synthesis wikiPageWikiLink Stereochemistry.
- Paclitaxel_total_synthesis wikiPageWikiLink Takahashi_Taxol_total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Taxadiene.
- Paclitaxel_total_synthesis wikiPageWikiLink Taxadienone.
- Paclitaxel_total_synthesis wikiPageWikiLink Taxus_baccata.
- Paclitaxel_total_synthesis wikiPageWikiLink Taxus_brevifolia.
- Paclitaxel_total_synthesis wikiPageWikiLink Total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink United_States.
- Paclitaxel_total_synthesis wikiPageWikiLink United_States_dollar.
- Paclitaxel_total_synthesis wikiPageWikiLink Wender_Taxol_total_synthesis.
- Paclitaxel_total_synthesis wikiPageWikiLink Wieland–Miescher_ketone.
- Paclitaxel_total_synthesis wikiPageWikiLink File:Original_semi-synthesis_of_taxol.png.
- Paclitaxel_total_synthesis wikiPageWikiLink File:Paclitaxel_JMolBiol_2001_1045.jpg.
- Paclitaxel_total_synthesis wikiPageWikiLink File:Paclitaxel_biosynthesis.svg.
- Paclitaxel_total_synthesis wikiPageWikiLink File:TaxolGeneralStructure.svg.
- Paclitaxel_total_synthesis wikiPageWikiLink File:TaxolNumberingScheme.svg.
- Paclitaxel_total_synthesis wikiPageWikiLink File:TaxolSemiSynthesisTaxanes.png.
- Paclitaxel_total_synthesis wikiPageWikiLinkText "Paclitaxel total synthesis".
- Paclitaxel_total_synthesis wikiPageWikiLinkText "paclitaxel total synthesis".
- Paclitaxel_total_synthesis wikiPageWikiLinkText "synthesis".
- Paclitaxel_total_synthesis wikiPageUsesTemplate Template:Reflist.
- Paclitaxel_total_synthesis subject Category:Taxanes.
- Paclitaxel_total_synthesis subject Category:Total_synthesis.
- Paclitaxel_total_synthesis hypernym Effort.
- Paclitaxel_total_synthesis type Organisation.
- Paclitaxel_total_synthesis comment "Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew (Taxus brevifolia).".
- Paclitaxel_total_synthesis label "Paclitaxel total synthesis".
- Paclitaxel_total_synthesis sameAs Q7123071.
- Paclitaxel_total_synthesis sameAs タキソール全合成.
- Paclitaxel_total_synthesis sameAs m.0b5zcn.
- Paclitaxel_total_synthesis sameAs Q7123071.
- Paclitaxel_total_synthesis sameAs 紫杉醇合成.
- Paclitaxel_total_synthesis wasDerivedFrom Paclitaxel_total_synthesis?oldid=696856316.
- Paclitaxel_total_synthesis depiction TaxolGeneralStructure.svg.
- Paclitaxel_total_synthesis isPrimaryTopicOf Paclitaxel_total_synthesis.