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- PYR-41 abstract "PYR-41 is the first cell permeable inhibitor of ubiquitin-activating enzyme E1,irreversibly inhibits ubiquitin-activating enzyme activity.It is a pyrazone compound that showed little or no activity on E2,E3.Unexpectedly, despite of ubiquitylation inhibition, PYR-41 also enhances total sumoylation in cells.PYR41 also blocks the downstream ubiquitination and ubiquitination-dependent protein degradation or other ubiquitination-mediated cellular activities. Besides, PYR-41 inhibits degradation of p53, a tumour suppressor and also activates the transcription activity of it. PYR-41 and related pyrazones selectively kill transformed p53 expressing cells, suggesting that E1 inhibitors may be potential therapeutics in cancer.".
- PYR-41 iupacName "4[4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester".
- PYR-41 thumbnail PYR-41.svg?width=300.
- PYR-41 wikiPageID "43944322".
- PYR-41 wikiPageLength "2462".
- PYR-41 wikiPageOutDegree "6".
- PYR-41 wikiPageRevisionID "679005674".
- PYR-41 wikiPageWikiLink P53.
- PYR-41 wikiPageWikiLink Pyrazone.
- PYR-41 wikiPageWikiLink SUMO_protein.
- PYR-41 wikiPageWikiLink Ubiquitin.
- PYR-41 wikiPageWikiLink Ubiquitin-activating_enzyme.
- PYR-41 imagefile "PYR-41.svg".
- PYR-41 iupacname "4".
- PYR-41 name "PYR-41".
- PYR-41 wikiPageUsesTemplate Template:Antineoplastic-drug-stub.
- PYR-41 wikiPageUsesTemplate Template:Chembox.
- PYR-41 wikiPageUsesTemplate Template:Chembox_Hazards.
- PYR-41 wikiPageUsesTemplate Template:Chembox_Identifiers.
- PYR-41 wikiPageUsesTemplate Template:Chembox_Properties.
- PYR-41 wikiPageUsesTemplate Template:Multiple_issues.
- PYR-41 wikiPageUsesTemplate Template:Orphan.
- PYR-41 wikiPageUsesTemplate Template:Reflist.
- PYR-41 wikiPageUsesTemplate Template:Technical.
- PYR-41 hypernym Inhibitor.
- PYR-41 type ChemicalCompound.
- PYR-41 type ChemicalSubstance.
- PYR-41 type Drug.
- PYR-41 type ChemicalObject.
- PYR-41 type Thing.
- PYR-41 type Q11173.
- PYR-41 comment "PYR-41 is the first cell permeable inhibitor of ubiquitin-activating enzyme E1,irreversibly inhibits ubiquitin-activating enzyme activity.It is a pyrazone compound that showed little or no activity on E2,E3.Unexpectedly, despite of ubiquitylation inhibition, PYR-41 also enhances total sumoylation in cells.PYR41 also blocks the downstream ubiquitination and ubiquitination-dependent protein degradation or other ubiquitination-mediated cellular activities.".
- PYR-41 label "PYR-41".
- PYR-41 sameAs Q18385814.
- PYR-41 sameAs m.0120y3mk.
- PYR-41 sameAs Q18385814.
- PYR-41 wasDerivedFrom PYR-41?oldid=679005674.
- PYR-41 depiction PYR-41.svg.
- PYR-41 isPrimaryTopicOf PYR-41.
- PYR-41 name "PYR-41".