Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/PRC200> ?p ?o }
- PRC200 abstract "PRC200-SS is an arylalkanolamine TRI being developed by the Mayo Clinic. Sympathomimetic PRC200-SS is the PRC050 eutomer, whereas PRC201 is the distomer. These compounds are preceded by venlafaxine, which Wyeth claims is the first SNRI. Venlafaxine was originally developed as an \"opioid\" although original screening returned negative results. The authors were not satisfied just to drop venlafaxine from development and continued with their study of the compounds biological activity data. Herein, they discovered that venlafaxine exerts its biological actions via interaction with the monoamine receptors. In particular, the actions of the drug on increasing the amount of 5-HT and NE were documented, although with \"potentiated\" analogs such as the pm-dichlorophenyl ring substituted derivative, it might be expected to behave as a SNDRI also (but no data was available to support this inference). Venlafaxine itself has been said to behave as a SNDRI at very high doses. This would be more likely to be the case in drug naїve subjects than in users that have already built up significant tolerance.Silicon containing analog of venlafaxine was prepared and demonstrated to be an active SNRI.".
- PRC200 iupacName "(1S,2S)-3-(methylamino)-2-naphthalen-2-yl-1-phenylpropan-1-ol".
- PRC200 pubchem "20631904".
- PRC200 thumbnail PRC200_structure.png?width=300.
- PRC200 wikiPageID "23928336".
- PRC200 wikiPageLength "15886".
- PRC200 wikiPageOutDegree "41".
- PRC200 wikiPageRevisionID "678437734".
- PRC200 wikiPageWikiLink 3,4-Dihydroxyphenylacetic_acid.
- PRC200 wikiPageWikiLink Amitriptyline.
- PRC200 wikiPageWikiLink Anisyl.
- PRC200 wikiPageWikiLink Biology.
- PRC200 wikiPageWikiLink Category:Alcohols.
- PRC200 wikiPageWikiLink Category:Amines.
- PRC200 wikiPageWikiLink Category:Naphthalenes.
- PRC200 wikiPageWikiLink Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- PRC200 wikiPageWikiLink Collecting_duct_system.
- PRC200 wikiPageWikiLink Crab-eating_macaque.
- PRC200 wikiPageWikiLink Cytoplasm.
- PRC200 wikiPageWikiLink Desipramine.
- PRC200 wikiPageWikiLink Diethylaminosulfur_trifluoride.
- PRC200 wikiPageWikiLink Diisopropyl_azodicarboxylate.
- PRC200 wikiPageWikiLink Distal_convoluted_tubule.
- PRC200 wikiPageWikiLink Dopamine_transporter.
- PRC200 wikiPageWikiLink Eudysmic_ratio.
- PRC200 wikiPageWikiLink File:PCarlier.png.
- PRC200 wikiPageWikiLink Homovanillic_acid.
- PRC200 wikiPageWikiLink Imipramine.
- PRC200 wikiPageWikiLink Mayo_Clinic.
- PRC200 wikiPageWikiLink Nortriptyline.
- PRC200 wikiPageWikiLink PRC200.
- PRC200 wikiPageWikiLink Permutation.
- PRC200 wikiPageWikiLink Phalkanolamine.
- PRC200 wikiPageWikiLink Rodent.
- PRC200 wikiPageWikiLink Serotonin.
- PRC200 wikiPageWikiLink Serotonin–norepinephrine_reuptake_inhibitor.
- PRC200 wikiPageWikiLink Serotonin–norepinephrine–dopamine_reuptake_inhibitor.
- PRC200 wikiPageWikiLink Silicon.
- PRC200 wikiPageWikiLink Sympathomimetic_drug.
- PRC200 wikiPageWikiLink Venlafaxine.
- PRC200 wikiPageWikiLink Wyeth.
- PRC200 wikiPageWikiLink File:PRCtwohundred.png.
- PRC200 wikiPageWikiLink File:Wyeth.png.
- PRC200 wikiPageWikiLink Wikipedia:OR.
- PRC200 wikiPageWikiLink Wikipedia:SYNTH.
- PRC200 wikiPageWikiLinkText "PRC200".
- PRC200 c "20".
- PRC200 chemspiderid "19318181".
- PRC200 date "November 2014".
- PRC200 h "21".
- PRC200 inchi "1".
- PRC200 inchikey "RSZGIFQDUIROGN-WOJBJXKFBB".
- PRC200 iupacName "-3".
- PRC200 molecularWeight "291.386".
- PRC200 n "1".
- PRC200 o "1".
- PRC200 pubchem "20631904".
- PRC200 reason "This is a very poorly written article, devoid of context for much of the content. Most abbreviations are undefined. The lists of data have no explanations for their meaning on relevance to the potential pharmacology. One table does not even mention what the numbers in it represent. The "Synthesis" section does not even try to explain the synthesis. Much of the text is speculative at best . It looks like someone just copied some data from various sources and dumped it together while adding some misguided speculations".
- PRC200 smiles "O[C@H][C@H]c2cc3ccccc3cc2".
- PRC200 stdinchi "1".
- PRC200 stdinchikey "RSZGIFQDUIROGN-WOJBJXKFSA-N".
- PRC200 verifiedfields "changed".
- PRC200 verifiedrevid "451223794".
- PRC200 watchedfields "changed".
- PRC200 wikiPageUsesTemplate Template:Abbreviations.
- PRC200 wikiPageUsesTemplate Template:Adrenergics.
- PRC200 wikiPageUsesTemplate Template:Antidepressants.
- PRC200 wikiPageUsesTemplate Template:Cascite.
- PRC200 wikiPageUsesTemplate Template:Chemspidercite.
- PRC200 wikiPageUsesTemplate Template:Cleanup.
- PRC200 wikiPageUsesTemplate Template:Context.
- PRC200 wikiPageUsesTemplate Template:Dopaminergics.
- PRC200 wikiPageUsesTemplate Template:Drugbox.
- PRC200 wikiPageUsesTemplate Template:Original_research.
- PRC200 wikiPageUsesTemplate Template:Reflist.
- PRC200 wikiPageUsesTemplate Template:Serotonergics.
- PRC200 wikiPageUsesTemplate Template:Stdinchicite.
- PRC200 wikiPageUsesTemplate Template:Synthesis.
- PRC200 wikiPageUsesTemplate Template:US_patent.
- PRC200 wikiPageUsesTemplate Template:US_patent_application.
- PRC200 subject Category:Alcohols.
- PRC200 subject Category:Amines.
- PRC200 subject Category:Naphthalenes.
- PRC200 subject Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- PRC200 hypernym TRI.
- PRC200 type ChemicalSubstance.
- PRC200 type Drug.
- PRC200 type Group.
- PRC200 type Acene.
- PRC200 type Alcohol.
- PRC200 type Chemical.
- PRC200 type Group.
- PRC200 type Inhibitor.
- PRC200 type ChemicalObject.
- PRC200 type Thing.
- PRC200 type Q8386.
- PRC200 comment "PRC200-SS is an arylalkanolamine TRI being developed by the Mayo Clinic. Sympathomimetic PRC200-SS is the PRC050 eutomer, whereas PRC201 is the distomer. These compounds are preceded by venlafaxine, which Wyeth claims is the first SNRI. Venlafaxine was originally developed as an \"opioid\" although original screening returned negative results. The authors were not satisfied just to drop venlafaxine from development and continued with their study of the compounds biological activity data.".
- PRC200 label "PRC200".
- PRC200 sameAs Q7120261.
- PRC200 sameAs m.076zhnx.