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- PPP1R3A abstract "Protein phosphatase 1 regulatory subunit 3A is an enzyme that in humans is encoded by the PPP1R3A gene.The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit (MIM 176875) and a 124-kD targeting and regulatory subunit, referred to as PP1G by Hansen et al. (1995). PP1G binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase (e.g., MIM 138570) and glycogen phosphorylase kinase (e.g., MIM 306000). Phosphorylation at ser46 of the PP1G subunit in response to insulin increases PP1 activity, while phosphorylation at ser65 in response to adrenaline causes dissociation of the catalytic subunit from the G subunit and inhibits glycogen synthesis. Because of these functions, PP1G was postulated to be involved in noninsulin-dependent diabetes mellitus (NIDDM; MIM 125853) and obesity.[supplied by OMIM]".
- PPP1R3A entrezgene "5506".
- PPP1R3A wikiPageID "14814410".
- PPP1R3A wikiPageLength "9656".
- PPP1R3A wikiPageOutDegree "2".
- PPP1R3A wikiPageRevisionID "673309825".
- PPP1R3A wikiPageWikiLink Enzyme.
- PPP1R3A wikiPageWikiLink Gene.
- PPP1R3A wikiPageWikiLinkText "PPP1R3A".
- PPP1R3A requireManualInspection "no".
- PPP1R3A summaryText "The glycogen-associated form of protein phosphatase-1 derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit, referred to as PP1G by Hansen et al. . PP1G binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase . Phosphorylation at ser46 of the PP1G subunit in response to insulin increases PP1 activity, while phosphorylation at ser65 in response to adrenaline causes dissociation of the catalytic subunit from the G subunit and inhibits glycogen synthesis. Because of these functions, PP1G was postulated to be involved in noninsulin-dependent diabetes mellitus and obesity.[supplied by OMIM]".
- PPP1R3A updateCitations "yes".
- PPP1R3A updatePage "yes".
- PPP1R3A updateProteinBox "yes".
- PPP1R3A updateSummary "yes".
- PPP1R3A wikiPageUsesTemplate Template:Cite_journal.
- PPP1R3A wikiPageUsesTemplate Template:Gene-7-stub.
- PPP1R3A wikiPageUsesTemplate Template:PBB.
- PPP1R3A wikiPageUsesTemplate Template:PBB_Controls.
- PPP1R3A wikiPageUsesTemplate Template:PBB_Further_reading.
- PPP1R3A wikiPageUsesTemplate Template:PBB_Summary.
- PPP1R3A wikiPageUsesTemplate Template:Refbegin.
- PPP1R3A wikiPageUsesTemplate Template:Refend.
- PPP1R3A wikiPageUsesTemplate Template:Reflist.
- PPP1R3A hypernym Enzyme.
- PPP1R3A type Biomolecule.
- PPP1R3A type Protein.
- PPP1R3A type Thing.
- PPP1R3A type Q206229.
- PPP1R3A type Q8054.
- PPP1R3A comment "Protein phosphatase 1 regulatory subunit 3A is an enzyme that in humans is encoded by the PPP1R3A gene.The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit (MIM 176875) and a 124-kD targeting and regulatory subunit, referred to as PP1G by Hansen et al. (1995).".
- PPP1R3A label "PPP1R3A".
- PPP1R3A sameAs Q18030706.
- PPP1R3A sameAs m.03gyvl7.
- PPP1R3A sameAs Q18030706.
- PPP1R3A wasDerivedFrom PPP1R3A?oldid=673309825.
- PPP1R3A isPrimaryTopicOf PPP1R3A.