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- POLI abstract "DNA polymerase iota is an enzyme that in humans is encoded by the POLI gene. It is found in higher eukaryotes, and is believed to have arisen from a gene duplication from Pol η. Pol ι, is a Y family polymerase that is involved in translesion synthesis. It can bypass 6-4 pyrimidine adducts and abasic sites and has a high frequency of wrong base incorporation. Like many other Y family polymerases Pol ι, has low processivity, a large DNA binding pocket and doesn't undergo conformational changes when DNA binds. These attributes are what allow Pol ι to carry out its task as a translesion polymerase. Pol ι only uses Hoogsteen base pairing, during DNA synthesis, it will add adenine opposite to thymine in the syn conformation and can add both cytosine and thymine in the anti conformation across guanine, which it flips to the syn conformation.".
- POLI entrezgene "11201".
- POLI wikiPageID "14150451".
- POLI wikiPageLength "7210".
- POLI wikiPageOutDegree "10".
- POLI wikiPageRevisionID "679003963".
- POLI wikiPageWikiLink Adenine.
- POLI wikiPageWikiLink Cytosine.
- POLI wikiPageWikiLink DNA_polymerase.
- POLI wikiPageWikiLink DNA_polymerase_eta.
- POLI wikiPageWikiLink DNA_repair.
- POLI wikiPageWikiLink Enzyme.
- POLI wikiPageWikiLink Gene.
- POLI wikiPageWikiLink Guanine.
- POLI wikiPageWikiLink Hoogsteen_base_pair.
- POLI wikiPageWikiLink Thymine.
- POLI wikiPageWikiLinkText "POLI".
- POLI wikiPageWikiLinkText "Pol ι".
- POLI requireManualInspection "no".
- POLI updateCitations "yes".
- POLI updatePage "yes".
- POLI updateProteinBox "yes".
- POLI updateSummary "yes".
- POLI wikiPageUsesTemplate Template:Cite_journal.
- POLI wikiPageUsesTemplate Template:Gene-18-stub.
- POLI wikiPageUsesTemplate Template:Other_uses.
- POLI wikiPageUsesTemplate Template:PBB.
- POLI wikiPageUsesTemplate Template:PBB_Controls.
- POLI wikiPageUsesTemplate Template:PBB_Further_reading.
- POLI wikiPageUsesTemplate Template:PBB_Summary.
- POLI wikiPageUsesTemplate Template:PDB_Gallery.
- POLI wikiPageUsesTemplate Template:Refbegin.
- POLI wikiPageUsesTemplate Template:Refend.
- POLI wikiPageUsesTemplate Template:Reflist.
- POLI hypernym Enzyme.
- POLI type Biomolecule.
- POLI type Protein.
- POLI type Thing.
- POLI type Q206229.
- POLI type Q8054.
- POLI comment "DNA polymerase iota is an enzyme that in humans is encoded by the POLI gene. It is found in higher eukaryotes, and is believed to have arisen from a gene duplication from Pol η. Pol ι, is a Y family polymerase that is involved in translesion synthesis. It can bypass 6-4 pyrimidine adducts and abasic sites and has a high frequency of wrong base incorporation.".
- POLI label "POLI".
- POLI sameAs Q18036384.
- POLI sameAs m.03cw4pp.
- POLI sameAs Q18036384.
- POLI wasDerivedFrom POLI?oldid=679003963.
- POLI isPrimaryTopicOf POLI.