Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/PNU-99,194> ?p ?o }
- PNU-99,194 abstract "PNU-99,194(A) (or U-99,194(A)) is a drug which acts as a moderately selective D3 receptor antagonist with ~15-30-fold preference for D3 over the D2 subtype. Though it has substantially greater preference for D3 over D2, the latter receptor does still play some role in its effects, as evidenced by the fact that PNU-99,194 weakly stimulates both prolactin secretion and striatal dopamine synthesis, actions it does not share with the more selective (100-fold) D3 receptor antagonists S-14,297 and GR-103,691.In rodent studies, low doses of PNU-99,194 produce conditioned place preference (CPP) with no effect on intracranial self-stimulation (ICSS), whereas low doses of D3 agonists like 7-OH-DPAT inhibit ICSS behavior and cause conditioned place aversion (CPA). In contrast, high doses of PNU-99,194 produce CPA and inhibit ICSS, while high doses of 7-OH-DPAT result in the opposite. Paralleling this, low doses of PNU-99,194 and 7-OH-DPAT induce hyperactivity and hypoactivity, respectively, whereas the inverse is seen at high doses with both agents. These data indicate that the D3 receptor has biphasic effects on reward mechanisms and locomotor activity, likely due to opposing roles of autoreceptors versus postsynaptic receptors.Other effects of PNU-99,194 at low doses in rodents include increased nociceptive responses, hypothermia, anxiolysis, and facilitation of learning and memory, as well as augmentation and inhibition, respectively, of amphetamine-induced reward and behavioral sensitization, and reversal of morphine-induced CPP. At high doses it inhibits the self-administration of cocaine in both rats and monkeys.".
- PNU-99,194 atcPrefix "none".
- PNU-99,194 casNumber "82668-33-5".
- PNU-99,194 casSupplemental "(hydrochloride)".
- PNU-99,194 casSupplemental "(maleate)".
- PNU-99,194 iupacName "5,6-dimethoxy-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine".
- PNU-99,194 pubchem "5626".
- PNU-99,194 thumbnail PNU-99194A-structure.png?width=300.
- PNU-99,194 wikiPageID "27160424".
- PNU-99,194 wikiPageLength "11877".
- PNU-99,194 wikiPageOutDegree "43".
- PNU-99,194 wikiPageRevisionID "679003888".
- PNU-99,194 wikiPageWikiLink 7-OH-DPAT.
- PNU-99,194 wikiPageWikiLink Addiction.
- PNU-99,194 wikiPageWikiLink Amphetamine.
- PNU-99,194 wikiPageWikiLink Animal_locomotion.
- PNU-99,194 wikiPageWikiLink Anxiolytic.
- PNU-99,194 wikiPageWikiLink Attention_deficit_hyperactivity_disorder.
- PNU-99,194 wikiPageWikiLink Autoreceptor.
- PNU-99,194 wikiPageWikiLink Binding_selectivity.
- PNU-99,194 wikiPageWikiLink Biosynthesis.
- PNU-99,194 wikiPageWikiLink Category:Amines.
- PNU-99,194 wikiPageWikiLink Category:Dopamine_antagonists.
- PNU-99,194 wikiPageWikiLink Category:Indanes.
- PNU-99,194 wikiPageWikiLink Category:Phenol_ethers.
- PNU-99,194 wikiPageWikiLink Category:Stimulants.
- PNU-99,194 wikiPageWikiLink Chemical_synapse.
- PNU-99,194 wikiPageWikiLink Conditioned_place_preference.
- PNU-99,194 wikiPageWikiLink Dopamine.
- PNU-99,194 wikiPageWikiLink Dopamine_receptor_D2.
- PNU-99,194 wikiPageWikiLink Dopamine_receptor_D3.
- PNU-99,194 wikiPageWikiLink Drug.
- PNU-99,194 wikiPageWikiLink GR-103,691.
- PNU-99,194 wikiPageWikiLink Hydrochloride.
- PNU-99,194 wikiPageWikiLink Hypoactivity.
- PNU-99,194 wikiPageWikiLink Hypothermia.
- PNU-99,194 wikiPageWikiLink Learning.
- PNU-99,194 wikiPageWikiLink Maleic_acid.
- PNU-99,194 wikiPageWikiLink Memory.
- PNU-99,194 wikiPageWikiLink Morphine.
- PNU-99,194 wikiPageWikiLink Mouth.
- PNU-99,194 wikiPageWikiLink Nociception.
- PNU-99,194 wikiPageWikiLink Prolactin.
- PNU-99,194 wikiPageWikiLink RDS-127.
- PNU-99,194 wikiPageWikiLink Receptor_(biochemistry).
- PNU-99,194 wikiPageWikiLink Receptor_antagonist.
- PNU-99,194 wikiPageWikiLink Reward_system.
- PNU-99,194 wikiPageWikiLink S-14,297.
- PNU-99,194 wikiPageWikiLink Secretion.
- PNU-99,194 wikiPageWikiLink Self-administration.
- PNU-99,194 wikiPageWikiLink Striatum.
- PNU-99,194 wikiPageWikiLink UH-232.
- PNU-99,194 wikiPageWikiLinkText "PNU-99,194".
- PNU-99,194 atcPrefix "none".
- PNU-99,194 c "17".
- PNU-99,194 casNumber "82668".
- PNU-99,194 chembl "16410".
- PNU-99,194 chemspiderid "5424".
- PNU-99,194 h "27".
- PNU-99,194 iupacName "56".
- PNU-99,194 legalStatus "Uncontrolled".
- PNU-99,194 molecularWeight "277.4".
- PNU-99,194 n "1".
- PNU-99,194 o "2".
- PNU-99,194 pubchem "5626".
- PNU-99,194 routesOfAdministration Mouth.
- PNU-99,194 smiles "OC".
- PNU-99,194 wikiPageUsesTemplate Template:CAS.
- PNU-99,194 wikiPageUsesTemplate Template:Dopaminergics.
- PNU-99,194 wikiPageUsesTemplate Template:Drugbox.
- PNU-99,194 wikiPageUsesTemplate Template:Reflist.
- PNU-99,194 wikiPageUsesTemplate Template:Stimulants.
- PNU-99,194 subject Category:Amines.
- PNU-99,194 subject Category:Dopamine_antagonists.
- PNU-99,194 subject Category:Indanes.
- PNU-99,194 subject Category:Phenol_ethers.
- PNU-99,194 subject Category:Stimulants.
- PNU-99,194 hypernym Drug.
- PNU-99,194 type ChemicalSubstance.
- PNU-99,194 type Drug.
- PNU-99,194 type Group.
- PNU-99,194 type Antagonist.
- PNU-99,194 type Drug.
- PNU-99,194 type Ether.
- PNU-99,194 type Group.
- PNU-99,194 type Hydrocarbon.
- PNU-99,194 type Psychoanaleptic.
- PNU-99,194 type Redirect.
- PNU-99,194 type Stimulant.
- PNU-99,194 type ChemicalObject.
- PNU-99,194 type Thing.
- PNU-99,194 type Q8386.
- PNU-99,194 comment "PNU-99,194(A) (or U-99,194(A)) is a drug which acts as a moderately selective D3 receptor antagonist with ~15-30-fold preference for D3 over the D2 subtype.".
- PNU-99,194 label "PNU-99,194".
- PNU-99,194 sameAs Q7119895.
- PNU-99,194 sameAs m.0bwjzm_.
- PNU-99,194 sameAs PNU-99,194.
- PNU-99,194 sameAs PNU-99,194.
- PNU-99,194 sameAs Q7119895.
- PNU-99,194 wasDerivedFrom PNU-99,194?oldid=679003888.