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- PIN_domain abstract "In molecular biology the PIN domain is a protein domain that is about 130 amino acids in length. The PIN domain was named after its identification in the N-terminus of the PilT protein (PilT N terminus). PIN domains function as nuclease enzymes that cleave single stranded RNA in a sequence dependent manner.PIN domains contain three nearly invariant acidic residues. Crystal structures show these residues clustered together in the putative active site. In eukaryotes PIN domains are found in proteins involved in nonsense mediated mRNA decay, in proteins such as SMG5 and SMG6, and in processing of 18S ribosomal RNA. The majority of PIN-domain proteins found in prokaryotes are the toxic components of toxin-antitoxin operons. These loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress.".
- PIN_domain symbol "PIN".
- PIN_domain thumbnail PDB_1o4w_EBI.jpg?width=300.
- PIN_domain wikiPageID "31416506".
- PIN_domain wikiPageLength "2033".
- PIN_domain wikiPageOutDegree "10".
- PIN_domain wikiPageRevisionID "592798172".
- PIN_domain wikiPageWikiLink Active_site.
- PIN_domain wikiPageWikiLink Category:Protein_domains.
- PIN_domain wikiPageWikiLink Nonsense-mediated_decay.
- PIN_domain wikiPageWikiLink Nuclease.
- PIN_domain wikiPageWikiLink Protein_domain.
- PIN_domain wikiPageWikiLink RNA.
- PIN_domain wikiPageWikiLink Ribosomal_RNA.
- PIN_domain wikiPageWikiLink SMG5.
- PIN_domain wikiPageWikiLink SMG6.
- PIN_domain wikiPageWikiLink Toxin-antitoxin_system.
- PIN_domain wikiPageWikiLinkText "PIN domain".
- PIN_domain wikiPageWikiLinkText "PilT N-terminus".
- PIN_domain caption "Crystal structure of PIN domain from Archaeoglobus fulgidus at 1.90 Angstrom resolution.".
- PIN_domain cdd "cd09852".
- PIN_domain interpro "IPR002716".
- PIN_domain name "PIN domain".
- PIN_domain pdb ", ,".
- PIN_domain pfam "PF01850".
- PIN_domain scop "3".
- PIN_domain smart "CBS".
- PIN_domain symbol "PIN".
- PIN_domain width "250".
- PIN_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- PIN_domain wikiPageUsesTemplate Template:PDB2.
- PIN_domain wikiPageUsesTemplate Template:Reflist.
- PIN_domain subject Category:Protein_domains.
- PIN_domain hypernym Domain.
- PIN_domain type Biomolecule.
- PIN_domain type Protein.
- PIN_domain type Chemical.
- PIN_domain type Domain.
- PIN_domain type Thing.
- PIN_domain type Q206229.
- PIN_domain type Q8054.
- PIN_domain comment "In molecular biology the PIN domain is a protein domain that is about 130 amino acids in length. The PIN domain was named after its identification in the N-terminus of the PilT protein (PilT N terminus). PIN domains function as nuclease enzymes that cleave single stranded RNA in a sequence dependent manner.PIN domains contain three nearly invariant acidic residues. Crystal structures show these residues clustered together in the putative active site.".
- PIN_domain label "PIN domain".
- PIN_domain sameAs Q17123408.
- PIN_domain sameAs m.0gkxpz7.
- PIN_domain sameAs Q17123408.
- PIN_domain wasDerivedFrom PIN_domain?oldid=592798172.
- PIN_domain depiction PDB_1o4w_EBI.jpg.
- PIN_domain isPrimaryTopicOf PIN_domain.