Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/P14arf> ?p ?o }
- P14arf abstract "p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). It accumulates mainly in the nucleolus where it forms stable complexes with NPM or Mdm2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting ribosome biogenesis or initiating p53-dependent cell cycle arrest and apoptosis, respectively. p14ARF is an atypical protein, in terms of its transcription, its amino acid composition, and its degradation: it is transcribed in an alternate reading frame of a different protein, it is highly basic, and it is polyubiquinated at the N-terminus.Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in mdm2 and, therefore, loss of p53 function and cell cycle control.The equivalent in mice is p19ARF.".
- P14arf arm "p".
- P14arf band "21".
- P14arf chromosome "9".
- P14arf entrezgene "1029".
- P14arf hgncid "1787".
- P14arf omim "600160".
- P14arf refseq "NM_058195".
- P14arf symbol "CDKN2, MLM".
- P14arf symbol "CDKN2A".
- P14arf uniprot "P42771".
- P14arf wikiPageExternalLink pmidlookup?view=long&pmid=10646864.
- P14arf wikiPageExternalLink S1097-2765(00)80351-2.
- P14arf wikiPageID "6766548".
- P14arf wikiPageLength "23396".
- P14arf wikiPageOutDegree "118".
- P14arf wikiPageRevisionID "673308076".
- P14arf wikiPageWikiLink Acetylation.
- P14arf wikiPageWikiLink Adenoma.
- P14arf wikiPageWikiLink Amino_acid.
- P14arf wikiPageWikiLink Apoptosis.
- P14arf wikiPageWikiLink Autophagy.
- P14arf wikiPageWikiLink Cancer.
- P14arf wikiPageWikiLink Carcinogenesis.
- P14arf wikiPageWikiLink Category:Human_genes.
- P14arf wikiPageWikiLink Cell_(biology).
- P14arf wikiPageWikiLink Cell_cycle.
- P14arf wikiPageWikiLink Cell_cycle_checkpoint.
- P14arf wikiPageWikiLink Cell_growth.
- P14arf wikiPageWikiLink Cell_nucleus.
- P14arf wikiPageWikiLink Chaperone_(protein).
- P14arf wikiPageWikiLink Chromosome.
- P14arf wikiPageWikiLink Cyclin.
- P14arf wikiPageWikiLink Cyclin-dependent_kinase.
- P14arf wikiPageWikiLink Cyclin-dependent_kinase_4.
- P14arf wikiPageWikiLink Cyclin-dependent_kinase_6.
- P14arf wikiPageWikiLink Cytoplasm.
- P14arf wikiPageWikiLink DNA.
- P14arf wikiPageWikiLink E2F.
- P14arf wikiPageWikiLink Enzyme.
- P14arf wikiPageWikiLink Eukaryote.
- P14arf wikiPageWikiLink Exon.
- P14arf wikiPageWikiLink G1_phase.
- P14arf wikiPageWikiLink Gene.
- P14arf wikiPageWikiLink Glioblastoma_multiforme.
- P14arf wikiPageWikiLink Half-life.
- P14arf wikiPageWikiLink Hydrophobe.
- P14arf wikiPageWikiLink Interphase.
- P14arf wikiPageWikiLink Lysine.
- P14arf wikiPageWikiLink Mdm2.
- P14arf wikiPageWikiLink Methionine.
- P14arf wikiPageWikiLink Methylation.
- P14arf wikiPageWikiLink Mitochondrial_matrix.
- P14arf wikiPageWikiLink Mitochondrion.
- P14arf wikiPageWikiLink Mitogen.
- P14arf wikiPageWikiLink Mutation.
- P14arf wikiPageWikiLink Myc.
- P14arf wikiPageWikiLink N-terminus.
- P14arf wikiPageWikiLink NPM1.
- P14arf wikiPageWikiLink Nuclear_localization_sequence.
- P14arf wikiPageWikiLink Nucleolus.
- P14arf wikiPageWikiLink Oncogene.
- P14arf wikiPageWikiLink P16.
- P14arf wikiPageWikiLink P21.
- P14arf wikiPageWikiLink P53.
- P14arf wikiPageWikiLink Phosphorylation.
- P14arf wikiPageWikiLink Promoter_(genetics).
- P14arf wikiPageWikiLink Protease.
- P14arf wikiPageWikiLink Proteasome.
- P14arf wikiPageWikiLink Protein.
- P14arf wikiPageWikiLink Protein_isoform.
- P14arf wikiPageWikiLink Ras_subfamily.
- P14arf wikiPageWikiLink Reading_frame.
- P14arf wikiPageWikiLink Retinoblastoma_protein.
- P14arf wikiPageWikiLink Ribosomal_RNA.
- P14arf wikiPageWikiLink Ribosome.
- P14arf wikiPageWikiLink SUMO_protein.
- P14arf wikiPageWikiLink S_phase.
- P14arf wikiPageWikiLink Small_interfering_RNA.
- P14arf wikiPageWikiLink Start_codon.
- P14arf wikiPageWikiLink Transcription_(genetics).
- P14arf wikiPageWikiLink Tumor_suppressor_gene.
- P14arf wikiPageWikiLink Ubiquitin.
- P14arf wikiPageWikiLink sup%3E.
- P14arf wikiPageWikiLinkText "INK4/ARF tumor suppressor".
- P14arf wikiPageWikiLinkText "P14arf".
- P14arf wikiPageWikiLinkText "alternate open reading frame (ARF)".
- P14arf wikiPageWikiLinkText "p14".
- P14arf wikiPageWikiLinkText "p14arf".
- P14arf altsymbols "CDKN2, MLM".
- P14arf arm "p".
- P14arf band "21".
- P14arf chromosome "9".
- P14arf entrezgene "1029".
- P14arf hgncid "1787".
- P14arf name "cyclin-dependent kinase inhibitor 2A".
- P14arf omim "600160".
- P14arf refseq "NM_058195".
- P14arf symbol "CDKN2A".
- P14arf uniprot "P42771".