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- Outer_membrane_phospholipase_A1 abstract "Outer membrane phospholipase A1 (OMPLA) is an acyl hydrolase with a broad substrate specificity (EC:3.1.1.32.) from the bacterial outer membrane. It has been proposed that Ser164 is the active site of the protein (UniProt P00631) This integral membrane phospholipase was found in many Gram-negative bacteria and has a broad substrate specificity EC 3.1.1.32. The role of OMPLA has been most thoroughly studied in Escherichia coli, where it participates in the secretion of bacteriocins. Bacteriocin release is triggered by a lysis protein (bacteriocin release protein or BRP), followed by a phospholipase dependent accumulation of lysophospholipids and free fatty acids in the outer membrane. The reaction products enhance the permeability of the outer membrane, which allows the semispecific secretion of bacteriocins. One speculative function of OMPLA is related to organic solvent tolerance in bacteria.Structurally, it consists of a 12-stranded antiparallel beta-barrel with a convex and a flat side. The active site residues are exposed on the exterior of the flat face of the beta-barrel. The activity of the enzyme is regulated by reversible dimerisation. Dimer interactions occur exclusively in the membrane-embedded parts of the flat side of the beta-barrel, with polar residues embedded in an apolar environment forming the key interactions. The active site His and Ser residues are located at the exterior of the beta-barrel, at the outer leaflet side of the membrane. This location indicates that under normal conditions the substrate and the active site are physically separated, since in E. coli phospholipids are exclusively located in the inner leaflet of the outer membrane.".
- Outer_membrane_phospholipase_A1 symbol "PLA1".
- Outer_membrane_phospholipase_A1 thumbnail 1qd6_opm.png?width=300.
- Outer_membrane_phospholipase_A1 wikiPageID "14604961".
- Outer_membrane_phospholipase_A1 wikiPageLength "3066".
- Outer_membrane_phospholipase_A1 wikiPageOutDegree "11".
- Outer_membrane_phospholipase_A1 wikiPageRevisionID "704615177".
- Outer_membrane_phospholipase_A1 wikiPageWikiLink Acyl.
- Outer_membrane_phospholipase_A1 wikiPageWikiLink Bacteriocin.
- Outer_membrane_phospholipase_A1 wikiPageWikiLink Beta_barrel.
- Outer_membrane_phospholipase_A1 wikiPageWikiLink Category:Outer_membrane_proteins.
- Outer_membrane_phospholipase_A1 wikiPageWikiLink Category:Protein_domains.
- Outer_membrane_phospholipase_A1 wikiPageWikiLink Escherichia_coli.
- Outer_membrane_phospholipase_A1 wikiPageWikiLink Gram-negative_bacteria.
- Outer_membrane_phospholipase_A1 wikiPageWikiLink Hydrolase.
- Outer_membrane_phospholipase_A1 wikiPageWikiLink Phospholipase.
- Outer_membrane_phospholipase_A1 wikiPageWikiLink UniProt.
- Outer_membrane_phospholipase_A1 wikiPageWikiLinkText "Outer membrane phospholipase A1".
- Outer_membrane_phospholipase_A1 interpro "IPR003187".
- Outer_membrane_phospholipase_A1 name "Phospholipase A1".
- Outer_membrane_phospholipase_A1 opmFamily "29".
- Outer_membrane_phospholipase_A1 opmProtein "1".
- Outer_membrane_phospholipase_A1 pfam "PF02253".
- Outer_membrane_phospholipase_A1 scop "1".
- Outer_membrane_phospholipase_A1 symbol "PLA1".
- Outer_membrane_phospholipase_A1 width "250".
- Outer_membrane_phospholipase_A1 wikiPageUsesTemplate Template:EC_number.
- Outer_membrane_phospholipase_A1 wikiPageUsesTemplate Template:Membrane-protein-stub.
- Outer_membrane_phospholipase_A1 wikiPageUsesTemplate Template:Pfam_box.
- Outer_membrane_phospholipase_A1 wikiPageUsesTemplate Template:Reflist.
- Outer_membrane_phospholipase_A1 wikiPageUsesTemplate Template:Uniprot.
- Outer_membrane_phospholipase_A1 subject Category:Outer_membrane_proteins.
- Outer_membrane_phospholipase_A1 subject Category:Protein_domains.
- Outer_membrane_phospholipase_A1 hypernym Hydrolase.
- Outer_membrane_phospholipase_A1 type Biomolecule.
- Outer_membrane_phospholipase_A1 type Enzyme.
- Outer_membrane_phospholipase_A1 type Protein.
- Outer_membrane_phospholipase_A1 type Chemical.
- Outer_membrane_phospholipase_A1 type Domain.
- Outer_membrane_phospholipase_A1 type Thing.
- Outer_membrane_phospholipase_A1 type Q206229.
- Outer_membrane_phospholipase_A1 type Q8054.
- Outer_membrane_phospholipase_A1 comment "Outer membrane phospholipase A1 (OMPLA) is an acyl hydrolase with a broad substrate specificity (EC:3.1.1.32.) from the bacterial outer membrane. It has been proposed that Ser164 is the active site of the protein (UniProt P00631) This integral membrane phospholipase was found in many Gram-negative bacteria and has a broad substrate specificity EC 3.1.1.32. The role of OMPLA has been most thoroughly studied in Escherichia coli, where it participates in the secretion of bacteriocins.".
- Outer_membrane_phospholipase_A1 label "Outer membrane phospholipase A1".
- Outer_membrane_phospholipase_A1 sameAs Q7112028.
- Outer_membrane_phospholipase_A1 sameAs Fosfolipase_A1_da_membrana_externa.
- Outer_membrane_phospholipase_A1 sameAs m.03d99t_.
- Outer_membrane_phospholipase_A1 sameAs Q7112028.
- Outer_membrane_phospholipase_A1 wasDerivedFrom Outer_membrane_phospholipase_A1?oldid=704615177.
- Outer_membrane_phospholipase_A1 depiction 1qd6_opm.png.
- Outer_membrane_phospholipase_A1 isPrimaryTopicOf Outer_membrane_phospholipase_A1.