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- Orteronel abstract "Orteronel (TAK-700) is a non-steroidal antiandrogen that was being developed for the treatment of cancer by Takeda Pharmaceutical Company in conjunction with Millennium Pharmaceuticals. It completed two phase III clinical trials for metastatic, hormone-refractory prostate cancer but failed to extend overall survival rates, and development was voluntarily terminated as a result.Orteronel is an androgen biosynthesis inhibitor. It selectively inhibits the enzyme CYP17A1 which is expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity thus decreases circulating levels of testosterone.".
- Orteronel iupacName "6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methylnaphthalene-2-carboxamide".
- Orteronel thumbnail Orteronel.svg?width=300.
- Orteronel wikiPageID "32684479".
- Orteronel wikiPageLength "4068".
- Orteronel wikiPageOutDegree "30".
- Orteronel wikiPageRevisionID "702250806".
- Orteronel wikiPageWikiLink Abiraterone_acetate.
- Orteronel wikiPageWikiLink Androgen.
- Orteronel wikiPageWikiLink Androstenedione.
- Orteronel wikiPageWikiLink Antiandrogen.
- Orteronel wikiPageWikiLink Apalutamide.
- Orteronel wikiPageWikiLink Biosynthesis.
- Orteronel wikiPageWikiLink CYP17A1.
- Orteronel wikiPageWikiLink Category:Abandoned_drugs.
- Orteronel wikiPageWikiLink Category:Antiandrogens.
- Orteronel wikiPageWikiLink Category:Carboxamides.
- Orteronel wikiPageWikiLink Category:Enzyme_inhibitors.
- Orteronel wikiPageWikiLink Category:Naphthalenes.
- Orteronel wikiPageWikiLink Category:Takeda_Pharmaceutical.
- Orteronel wikiPageWikiLink Clinical_trial.
- Orteronel wikiPageWikiLink Cyproterone_acetate.
- Orteronel wikiPageWikiLink Dehydroepiandrosterone.
- Orteronel wikiPageWikiLink EPI-001.
- Orteronel wikiPageWikiLink Enzalutamide.
- Orteronel wikiPageWikiLink Enzyme_inhibitor.
- Orteronel wikiPageWikiLink Galeterone.
- Orteronel wikiPageWikiLink Ketoconazole.
- Orteronel wikiPageWikiLink Metastasis.
- Orteronel wikiPageWikiLink Millennium_Pharmaceuticals.
- Orteronel wikiPageWikiLink Nonsteroidal.
- Orteronel wikiPageWikiLink ODM-201.
- Orteronel wikiPageWikiLink Phases_of_clinical_research.
- Orteronel wikiPageWikiLink Prostate_cancer.
- Orteronel wikiPageWikiLink Takeda_Pharmaceutical_Company.
- Orteronel wikiPageWikiLink Testosterone.
- Orteronel wikiPageWikiLink VT-464.
- Orteronel wikiPageWikiLinkText "Orteronel".
- Orteronel wikiPageWikiLinkText "orteronel".
- Orteronel imagefile "Orteronel.svg".
- Orteronel imagesize "200".
- Orteronel iupacname "6".
- Orteronel othernames "TAK-700".
- Orteronel wikiPageUsesTemplate Template:Androgenics.
- Orteronel wikiPageUsesTemplate Template:Antiandrogens.
- Orteronel wikiPageUsesTemplate Template:Cascite.
- Orteronel wikiPageUsesTemplate Template:Chembox.
- Orteronel wikiPageUsesTemplate Template:Chembox_Hazards.
- Orteronel wikiPageUsesTemplate Template:Chembox_Identifiers.
- Orteronel wikiPageUsesTemplate Template:Chembox_Properties.
- Orteronel wikiPageUsesTemplate Template:Drug-stub.
- Orteronel wikiPageUsesTemplate Template:Keggcite.
- Orteronel wikiPageUsesTemplate Template:Reflist.
- Orteronel wikiPageUsesTemplate Template:Steroid_hormone_metabolism_modulators.
- Orteronel subject Category:Abandoned_drugs.
- Orteronel subject Category:Antiandrogens.
- Orteronel subject Category:Carboxamides.
- Orteronel subject Category:Enzyme_inhibitors.
- Orteronel subject Category:Naphthalenes.
- Orteronel subject Category:Takeda_Pharmaceutical.
- Orteronel hypernym Antiandrogen.
- Orteronel type ChemicalCompound.
- Orteronel type ChemicalSubstance.
- Orteronel type Drug.
- Orteronel type Group.
- Orteronel type Acene.
- Orteronel type Amide.
- Orteronel type Drug.
- Orteronel type Group.
- Orteronel type ChemicalObject.
- Orteronel type Thing.
- Orteronel type Q11173.
- Orteronel comment "Orteronel (TAK-700) is a non-steroidal antiandrogen that was being developed for the treatment of cancer by Takeda Pharmaceutical Company in conjunction with Millennium Pharmaceuticals. It completed two phase III clinical trials for metastatic, hormone-refractory prostate cancer but failed to extend overall survival rates, and development was voluntarily terminated as a result.Orteronel is an androgen biosynthesis inhibitor.".
- Orteronel label "Orteronel".
- Orteronel sameAs Q6581305.
- Orteronel sameAs ارترونل.
- Orteronel sameAs m.0h3x2ck.
- Orteronel sameAs Orteronel.
- Orteronel sameAs Orteronel.
- Orteronel sameAs Q6581305.
- Orteronel wasDerivedFrom Orteronel?oldid=702250806.
- Orteronel depiction Orteronel.svg.
- Orteronel isPrimaryTopicOf Orteronel.