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- Org_27569 abstract "Org 27569 is a drug which acts as a potent and selective allosteric modulator of the cannabinoid CB1 receptor. Studies in vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists such as rimonabant. However while Org 27569 increases the ability of CB1 agonists to bind to the receptor, it decreases their efficacy at stimulating second messenger signalling once bound, and so in practice behaves as an insurmountable antagonist of CB1 receptor function.".
- Org_27569 casNumber "868273-06-7".
- Org_27569 iupacName "5-chloro-3-ethyl-1H-indole-2-carboxylic acid[2-(4-piperidin-1-yl-phenyl)ethyl]amide".
- Org_27569 pubchem "44828492".
- Org_27569 thumbnail Org27569_structure.png?width=300.
- Org_27569 wikiPageID "30414640".
- Org_27569 wikiPageLength "2524".
- Org_27569 wikiPageOutDegree "11".
- Org_27569 wikiPageRevisionID "700611243".
- Org_27569 wikiPageWikiLink Allosteric_modulator.
- Org_27569 wikiPageWikiLink CP_55,940.
- Org_27569 wikiPageWikiLink Cannabinoid.
- Org_27569 wikiPageWikiLink Cannabinoid_receptor_type_1.
- Org_27569 wikiPageWikiLink Category:CB1_receptor_antagonists.
- Org_27569 wikiPageWikiLink Category:Cannabinoids.
- Org_27569 wikiPageWikiLink Dissociation_constant.
- Org_27569 wikiPageWikiLink Receptor_(biochemistry).
- Org_27569 wikiPageWikiLink Receptor_antagonist.
- Org_27569 wikiPageWikiLink Rimonabant.
- Org_27569 wikiPageWikiLink Second_messenger_system.
- Org_27569 wikiPageWikiLinkText "Org 27569".
- Org_27569 c "24".
- Org_27569 casNumber "868273".
- Org_27569 chemspiderid "22369629".
- Org_27569 cl "1".
- Org_27569 h "28".
- Org_27569 iupacName "5".
- Org_27569 iupharLigand "7851".
- Org_27569 molecularWeight "409.951".
- Org_27569 n "3".
- Org_27569 o "1".
- Org_27569 pubchem "44828492".
- Org_27569 smiles "CCc1c2ccccc2nc1CNCCc3cccN4CCCCC4".
- Org_27569 stdinchi "1".
- Org_27569 stdinchikey "AHFZDNYNXFMRFQ-UHFFFAOYSA-N".
- Org_27569 verifiedrevid "451565501".
- Org_27569 width "250".
- Org_27569 wikiPageUsesTemplate Template:Cannabinoid-stub.
- Org_27569 wikiPageUsesTemplate Template:Cannabinoidergics.
- Org_27569 wikiPageUsesTemplate Template:Cannabinoids.
- Org_27569 wikiPageUsesTemplate Template:Cascite.
- Org_27569 wikiPageUsesTemplate Template:Chemspidercite.
- Org_27569 wikiPageUsesTemplate Template:Drugbox.
- Org_27569 wikiPageUsesTemplate Template:Stdinchicite.
- Org_27569 subject Category:CB1_receptor_antagonists.
- Org_27569 subject Category:Cannabinoids.
- Org_27569 hypernym Drug.
- Org_27569 type ChemicalSubstance.
- Org_27569 type Drug.
- Org_27569 type Cannabinoid.
- Org_27569 type Drug.
- Org_27569 type ChemicalObject.
- Org_27569 type Thing.
- Org_27569 type Q8386.
- Org_27569 comment "Org 27569 is a drug which acts as a potent and selective allosteric modulator of the cannabinoid CB1 receptor. Studies in vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists such as rimonabant.".
- Org_27569 label "Org 27569".
- Org_27569 sameAs Q7101736.
- Org_27569 sameAs m.0g5qtjx.
- Org_27569 sameAs Org_27569.
- Org_27569 sameAs Org_27569.
- Org_27569 sameAs Q7101736.
- Org_27569 wasDerivedFrom Org_27569?oldid=700611243.
- Org_27569 depiction Org27569_structure.png.
- Org_27569 isPrimaryTopicOf Org_27569.